Search results for "PEF"
showing 10 items of 67 documents
Impact of operation condition on temperature distribution in single cell of polymer electrolyte fuel cell operated at higher temperature than usual
2016
For improving performance of the stationary Polymer Electrolyte Fuel Cell (PEFC) system, the cell operating temperature up to 90°C will be preferred in Japan during the period from 2020 to 2030. To understand the operation of the PEFC system under relatively high temperature conditions, detail heat and mass transfer analysis is required. The main focus of this study is to analyze the PEFC performance under operational conditions, such as initial operational temperature of cell (Tini), relative humidity of supply gas, and the cathode gas type, temperature distribution in a cell of PEFC (using Nafion membrane) under relatively higher operating temperature conditions. The in-plane temperature …
Profili penali e problemi politico-criminali dell'intervento multilivello sugli stupefacenti
2014
l contributo esamina alcuni problemi di fondo connessi all’intervento penalistico in materia di stupefacenti, assumendolo quale settore esemplare per indicare la complessità del diritto penale moderno. In particolare, si segnala tanto la difficoltà di ricostruire la prevenzione del relativo fenomeno sociale come affidato a strumenti omogenei, quanto la crisi del ruolo di extrema ratio del diritto penale all’interno di tale articolata serie di interventi. Le principali vicende italiane sulle fondamentali opzioni in materia sono quindi collocate nello scenario internazionale, che condiziona i sistemi giuridici statuali ad una strategia differenziata rispetto ai due versanti del traffico illec…
Fondements et approches de modélisation 3D des environnements urbains pour la géosimulation
2015
National audience; Dans le prolongement de la théorie de la géographie virtuelle proposée par Mi¬chael Batty (1997, 2008), les Environne¬ments Géographiques Virtuels (EGVs) sont proposés comme une nouvelle génération d’outils d’analyses géographiques, d’amé¬nagements et de prospective de façon plus approfondie (Lin et al., 2012). Le déve¬loppement des EGVs répond aux trois exigences scientifiques fondamentales des sciences de l’information géographique : vi-sualisation multidimensionnelle, simulation dynamique de phénomènes géographiques et la participation collaborative pluridisci¬plinaire (Goodchild, 2009). A ce titre, les Environnements Virtuels Urbains pour la Géosimulation (EVUG) sont …
Osservatorio della Corte costituzionale (n. 6/2016)
2016
Corte cost. n. 125 del 2016 (in tema di pene detentive brevi, sospensione dell’esecuzione, limiti per tipologie di reato e inclusione del furto con strappo nel novero dei reati ostativi), Corte cost. n. 109 del 2016 (in tema di coltivazione di piante di cannabis, selezione delle condotte sanzionate e architetture valoriali di sistema)
Fruits and vegetables protect against the genotoxicity of heterocyclic aromatic amines activated by human xenobiotic-metabolizing enzymes expressed i…
2010
Heterocyclic aromatic amines (HAAs) can be formed during the cooking of meat and fish at elevated temperatures and are associated with an increased risk for cancer. On the other hand, epidemiological findings suggest that foods rich in fruits and vegetables can protect against cancer. In the present study three teas, two wines, and the juices of 15 fruits and 11 vegetables were investigated for their protective effect against the genotoxic effects of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). To closely mimic the enzymatic activation of these HAAs in humans, genetically engineered V79 Chinese hamster fibroblasts were employed tha…
Effect of cytochrome P450 inhibitors (diethyl dithiocarbamate, ketoconazole and grapefruit juice) on the pharmacokinetics of all-trans-retinoic acid.
2004
Diethyl dithiocarbamate (DEDTC) has been reported to be a more powerful inhibitor of all-trans-retinoic acid (ATRA) in vitro metabolism than the well-established cytochrome P450 (CYP) inhibitor ketoconazole (KC). In recent years grapefruit juice (GJ) has been shown to be able to increase the oral bioavailability of several drugs by inhibiting intestinal CYP. This study investigated the in vivo effect of these CYP inhibitors on the pharmacokinetics of ATRA. The latter was administered to rats as a constant-rate intravenous (i.v.) infusion (0.48 mg h(-1) kg(-1)) during 10 h and orally (1.6 mg kg(-1)). DEDTC (320 mg kg(-1) x 2 i.v., 6.4 and 32 mg kg(-1) per os (p.o.)) did not change the ATRA c…
Early sudden gains in an acceptance and values-based intervention: Effects on treatment outcome for depression and psychological flexibility
2018
Abstract Objective The aim of this study was to explore early temporal patterns of change in a treatment delivered by novice therapists. We examined if early sudden gains (ESGs) in a six-session acceptance and values-based intervention would produce superior treatment outcomes when compared to slower improvements. Method The temporal patterns of change of 56 clients diagnosed with depression were analyzed. ESGs were defined as reaching the status of recovered or improved in the Reliable Change Index (RCI) (Jacobson & Truax (1991)) classification after two sessions. The group with ESGs was then compared to participants without ESGs for differences in treatment outcome on measures of symptoma…
Long-term stability of early sudden gains in an acceptance and values-based intervention
2019
Though previous research has extensively reported that sudden gains are associated with superior treatment results, research on the long-term effects and stability of sudden gains is not as consistent. The current study explored the long-term stability of early sudden gains (ESGs) observed in a brief acceptance and values-based intervention for depression provided by novice therapists. The participants were 56 volunteers diagnosed with major depressive disorder. Among the participants, 23% experienced ESGs, i.e. they reached the status of improved or recovered in the Reliable Change Index (RCI; Jacobson & Truax, 1991) classification after only two sessions. The current study examined the le…
Differential effects of MDMA and cocaine on inhibitory avoidance and object recognition tests in rodents.
2017
Introduction Drug addiction continues being a major public problem faced by modern societies with different social, health and legal consequences for the consumers. Consumption of psychostimulants, like cocaine or MDMA (known as ecstasy) are highly prevalent and cognitive and memory impairments have been related with the abuse of these drugs. Aim The aim of this work was to review the most important data of the literature in the last 10 years about the effects of cocaine and MDMA on inhibitory avoidance and object recognition tests in rodents. Development: The object recognition and the inhibitory avoidance tests are popular procedures used to assess different types of memory. We compare th…
Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction
2021
BACKGROUND Chronotropic incompetence has shown to be associated with a decrease in exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet b-blockers are commonly used in HFpEF despite the lack of robust evidence. OBJECTIVES This study aimed to evaluate the effect of b-blocker withdrawal on peak oxygen consumption (peak VO2) in patients with HFpEF and chronotropic incompetence. METHODS This is a multicenter, randomized, investigator-blinded, crossover clinical trial consisting of 2 treatment periods of 2 weeks separated by a washout period of 2 weeks. Patients with stable HFpEF, New York Heart Association functional classes II and III, previous treatment with b-bloc…