Search results for "PERK"
showing 10 items of 75 documents
Expression of NF-κB and IL-6 in oral precancerous and cancerous lesions: An immunohistochemical study.
2014
Background The purpose of this study was to evaluate the immunohistochemical expression of NF-κB and IL-6 in oral premalignant and malignant lesions and to investigate their possible correlation with the presence of subepithelial inflammation. Material and Methods Thirty two oral premalignant lesions, clinically compatible with leukoplakia or erythroplakia, were investigated. Microscopically, 11 of them showed hyperkeratosis and acanthosis (epithelial hyperplasia) and 21 showed dysplasia of varying degrees. Nine cases of OSCC and four control cases of normal oral mucosa were also included in the study. Immunohistochemical staining with NF-κB (p65) and IL-6 was performed. IL-6 and nuclear NF…
The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor
2021
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-stress-regulated protein exhibiting cytoprotective properties through a poorly understood mechanism in various in vitro and in vivo models of neuronal and non-neuronal damage. Although initially characterized as a secreted neurotrophic factor for midbrain dopamine neurons, MANF has recently gained more interest for its intracellular role in regulating the ER homeostasis, including serving as a cofactor of the chaperone glucose-regulated protein 78 (GRP78). We aimed for a better understanding of the neuroprotective mechanisms of MANF. Here we show for the first time that MANF promotes the survival of …
Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders.
2017
Abstract Plasticity related gene 1 (PRG-1) is a neuron specific membrane protein located at the postsynaptic density of glutamatergic synapses. PRG-1 modulates signaling pathways of phosphorylated lipid substrates such as lysophosphatidic acid (LPA). Deletion of PRG-1 increases presynaptic glutamate release probability leading to neuronal over-excitation. However, due to its cortical expression, PRG-1 deficiency leading to increased glutamatergic transmission is supposed to also affect motor pathways. We therefore analyzed the effects of PRG-1 function on exploratory and motor behavior using homozygous PRG-1 knockout (PRG-1−/−) mice and PRG-1/LPA2–receptor double knockout (PRG-1−/−/LPA2−/−)…
2021
The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further str…
Perkusīvie instrumenti 5-6 gadīgu bērnu ritma izjūtas attīstīšanai pirmsskolā
2020
Danas Ščerbinas kvalifikācijas darba tēma ir „Perkusīvie instrumenti 5-6 gadīgu bērnu ritma izjūtas attīstīšanai pirmsskolā”. Tajā aplūkota aktuāla problēma – perkusīvo instrumentu nepietiekama izmantošana pirmsskolas izglītības iestādēs, kā arī nepietiekamais ritma izjūtas attīstības līmenis minētajā vecumposmā – 5-6 gadi. Darbā tika veikta teorētiskas literatūras analīze par ritma izjūtu, par perkusīviem instrumentiem, par perkusīvo instrumentu izmantošanas iespējām pirmsskolas izglītības iestādē un tika sniegts 5-6 gadīgo bērnu raksturojums. Kvalifikācijas darbā galvenais ritma izjūtas attīstīšanas palīglīdzeklis– perkusīvie instrumenti. Literatūras analīzes mērķis ir izpētīt, kā perkusī…
Histopathological characterization of the oral lichenoid disease subtypes and the relation with the clinical data
2016
Background: The aim of the study was to analyze the histopathological characteristics of samples with a diagnosis of oral lichenoid disease (OLD) and their link with the location and the type of clinical lesion, and the clinicopathological subtypes.
Histopathological findings in oral lichen planus and their correlation with the clinical manifestations
2010
Objectives: To highlight the most characteristic histopathological findings of oral lichen planus and their correlation with the clinical manifestations and forms. Study design: We performed a retrospective study of 50 biopsied and diagnosed cases of oral lichen planus obtained over a period of 11 years, spanning from May 1998 to April 2009. We analyzed the age and sex of the patient, type of lichen planus, location and different histopathological findings, comparing them with the clinical lesions. Results: Seventy eight percent of the patients are female and 22% are male, with an average age of 56.06 years for both sexes. The most frequent clinical form is reticular, present in 78% of the …
The Effectiveness of Laser-Assisted Surgical Excision of Leukoplakias and Hyperkeratosis of Oral Mucosa: A Case Series in A Group of Patients
2019
Introduction: In the different branches of dentistry, the use of laser to solve different clinical situations is increasing due to numerous advantages that have been studied in literature since the 70s. Leucoplakia and hyperkeratosis can benefit from laser-assisted treatment. In most cases biopsy sampling, histological examination and, if no malignant cells are present, the follow-up is needed. However, even if the lesion is free of dysplasia patients often ask to eliminate these white spots that are always a cause of concern. Aim: From these numerous requests comes the idea of setting up a laser-assisted protocol as less invasive as possible to be offered to patients. The aim of the study …
Pitfall prayer marks: Recognition and appropriate treatment: A case report and review of literature.
2019
Prayer marks are asymptomatic callosities resulting from repeated, extended pressure, and friction exerted on bony prominences when praying on hard ground. A 41-year-old woman with ulcerative colitis treated with infliximab was referred to our clinic due to skin changes on her feet that were suspected to be drug eruptions. The patient presented several asymptomatic, hyperpigmented, and hyperkeratotic plaques over the lateral malleoli suggesting that the lesions had a mechanical cause. Further exploration revealed that the patient, a practicing Muslim, prays in a sitting position called "Julus" several times a day. After color marking, the lesions over the lateral feet left a precise imprint…
Optiskās koherences tomogrāfijas loma vēlīnās vaskulārās atbildes reakcijas novērtēšanā pēc biorezorbējošā stenta implantācijas
2019
Ievads. Pēdējos gados pieaug perkutānas koronārās intervences pielietojums, jo šobrīd tā ir viena no galvenajām metodēm koronārās sirds slimības ārstēšanā. Laika gaitā perkutānā koronārā intervence (PKI) ir pieredzējusi ievērojamu ārstniecisko attīstību. Ievērojami uzlabojumi ir stentu tehnoloģijā, kā arī tehniski uzlabojumi un farmakoterapijas progress arvien vairāk uzlabo PKI rezultātus. Bioresorbējošie koronārie stenti ir ievērojama inovācija, kam ir potenciāls uzlabot ārstēšanas rezultātus pacientiem, kam veic PKI, un to mērķis ir mazināt metāla stentu trūkumus. Pētījuma mērķis: Novērtēt vaskulārās atbildes reakciju, izmantojot optiskās koherences mērījumus, pacientiem tūlīt, pēc viena …