Search results for "PERK"
showing 10 items of 75 documents
Miokarda infarkta ārstēšanas un iznākuma atšķirības pacientu populācijā virs 45 gadiem un pacientu populācijā virs 75 gadiem
2021
Ievads Latvijā viena no izplatītākajām sirds un asinsvadu slimībām ir miokarda infarkts. Balstoties uz Slimību profilakses un kontroles centra datiem, ar infarktu ik gadu Latvijā mirst vairāk nekā 1000 iedzīvotāju. 20% no tiem 2019. gadā bija vecumā līdz 64 gadiem un 80% pēc 64 gadu vecuma. Slimība ir izplatīta dažādās vecuma grupās. Vecuma grupā virs 75 gadu vecuma tā tiek retāk pētīta. Šādi pacienti bieži netiek iekļauti klīniskajos pētījumos. Pacienti vecuma grupā 75+ retāk saņem adekvātu pirmo palīdzību, sakarā ar novēlotu simptomu atpazīstamību vai simptomu citādāku izpausmi vai to neizpausmi. Darba mērķis ir izvērtēt miokarda infarkta nozīmi un ārstēšanas modeli Latvijā. Salīdzināt ār…
Koronāro bifurkāciju perkutānās ārstēšanas stratēģijas ietekme uz intrahospitālajiem notikumiem
2022
Ievads. Apmēram 15-20% perkutānā koronārā intervence tiek pielietota, lai ārstētu koronāro bifurkāciju bojājumus. Perkutānā koronārā intervence koronāro bifurkāciju ārstēšanas gadījumā tiek uzskatīta par izaicinošu un sarežģītu, kā arī tiek asociēta ar nelabvēlīgākiem intrahospitālajiem un ilgtermiņa iznākumiem, salīdzinājumā ar ne-bifurkāciju bojājumiem. Darba mērķis. Izvērtēt intrahospitālās un procedurālās komplikācijas pacientiem, kuriem tika veikta īsto koronāro bifurkāciju bojājuma perkutānā koronārā intervence (PCI) un noskaidrot šo iznākumu saistību ar izvēlēto ārstēšanas stratēģiju. Materiāli un metodes. Kohortā retrospektīvā pētījumā tika iekļauti 603 pacienti no Latvijas Kardiolo…
Brugada phenocopy in diabetic ketoacidosis, the importance of the diagnostic approach
2020
Abstract Brugada phenocopies (BrP) are clinical entities that present with identical ECG patterns to those of true Brugada Syndrome (BrS) but are elicited by various other clinical circumstances. Our manuscript shows an interesting case of a type-1 Class A BrP in a young patient with diabetic ketoacidosis and hyperkalemia.
Functional food science and behaviour and psychological functions
2017
INSERM-Unite 341 et Service de Nutrition, Hotel-Dieu, Paris, France. bellisle@imaginet.frThe impact of ingesting various foods on psychological and behavioural functions is a topic of both interest and concern to the general public. In this article, the scientific literature concerning demonstrated cause-and-effect relationships is reviewed, beginning with methodological considerations specific to the quantification of particular behaviours and psychological events. The essential function of food is to satisfy hunger and the need for essential nutrients. The contributions of macronutrients to appetite and satiety are described, as well as their impact on metabolism and energy balance. Funct…
Timing of Renal Replacement Therapy for Severe Acute Kidney Injury in Critically Ill Patients
2019
Acute kidney injury (AKI) affects many ICU patients and is responsible for increased morbidity and mortality. Although lifesaving in many situations, renal replacement therapy (RRT) may be associated with complications, and the appropriate timing of its initiation is still the subject of intense debate. An early initiation strategy can prevent some metabolic complications, whereas a delayed one may allow for renal function recovery in some patients without need for this costly and potentially dangerous technique. For years, most of the knowledge on this issue stemmed from observational studies or small randomized controlled trials. Recent randomized controlled trials have indicated that a w…
Star calculus on Jacobi manifolds
2002
Abstract We study the Gerstenhaber bracket on differential forms induced by the two main examples of Jacobi manifolds: contact manifolds and l.c.s. manifolds. Moreover, we obtain explicit expressions of the generating operators and the derivations on the algebra of multivector fields. We define star operators for contact manifolds and l.c.s. manifolds and we study some of its properties.
A method for skin malformation classification by combining multispectral and skin autofluorescence imaging
2018
As the incidence of skin cancer is still increasing worldwide, there is a high demand for early, non-invasive and inexpensive skin lesion diagnostics. In this article we describe and combine two skin imaging methods: skin autofluorescence (AF) and multispectral criterion p’. To develop this method, we used custom made prototype with 405 nm, 526 nm, 663 nm and 964 nm LED illuminations, perpendicular positioned linear polarizers, 515 nm filter and IDS camera. Our aim is to develop a skin lesion diagnostic device for primary care physicians who do not have experience in dermatology or skin oncology. In this study we included such common benign lesion groups as seborrheic keratosis, hyperkerato…
UNRAVELLING THE ROLES OF THE NUCLEAR PROTEIN 1 DURING ER-STRESS INDUCTION
2020
Background: NUPR1 was described as a transcriptional factor involved in the regulation of various cellular stress-response genes, playing a crucial role in the condition of the endoplasmic-reticulum (ER) stress, thus emerging as a common molecular factor of different pathologies, obesity, hepatic steatosis, and cancer. In the present work we aim to explore how NUPR1 interacts with some pivotal genes that are the major modulators of the ER stress and metabolic cell functions. In particular we investigated the biochemical and molecular effects arising from the loss of NUPR1 in ER stress physiological conditions. Methods: We used prolonged high fat diet (HFD) feeding to induce ER stress physio…
BRUGADA PATTERN IN HEROIN ADDICTION: SYNDROME OR PHENOCOPY?
2020
Brugada phenocopies (BrPs) are clinical entities that show an electrocardiogram (ECG) pattern similar to what is observed in Brugada syndrome (BrS). They are caused by different clinical conditions. We describe a case of BrP in a man that developed acute kidney failure secondary to rhabdomyolysis, after heroin addiction. His initial ECG showed Brugada type 1 pattern resolved after hemodialytic treatment. A provocative test with ajmaline, which resulted negative, was performed to confirm the diagnosis. BrPs can mimic a true BrS and a fast recognition of these clinical and electrocardiographic findings may avoid diagnostic mistakes thus preventing unnecessary or inaccurate treatmen
The "Neurocentric" Approach to Essential Hypertension: How Reliable is the Paradigm of Hyperkinetic Hypertension? A Focus on the Sympathetic Nervous …
2017
BACKGROUND: Clinic resting heart rate (RHR), is one of the cardiovascular parameters more easily measurable. In the general population RHR has been associated with total and cardiovascular mortality and higher rate of vascular events. OBJECTIVE: The case of essential hypertension is in some ways peculiar: in the past decades has often been attributed to hypertensive subjects higher values of RHR than healthy controls as a result of the effects of the different factors leading to the development of essential hypertension itself, first of all the presence of an increased tone of the sympathetic nervous system Methods: Several excellent articles debated the issue of autonomic dysfunction in es…