Search results for "PHEA"
showing 10 items of 60 documents
NOVEL AMPHIPHILIC COPOLYMERS BASED ON POLYASPARTAMIDE GRAFT WITH SQUALENE RESIDUES TO OBTAIN MICELLES AS COLLOIDAL DRUG CARRIERS.
2009
FIBRILLAR SCAFFOLD BASED ON ELECTROSPUN alpha,beta-POLY(N-2-HYDROXYETHYL)-DL-ASPARTAMIDE-GRAFT-POLYLACTIC ACID COPOLYMER.
2009
POLYMERIC MICELLES BASED ON A PHOSPHOLIPID/ POLYASPARTAMIDIC COPOLYMER FOR BECLOMETHASONE DIPROPIONATE DELIVERY TO THE LUNGS
2010
Biocompatibility and biodegradability of electrospun phea-pla scaffolds: Our preliminary experience in a murine animal model
2012
We obtained a nano-fibrillar scaffold starting from a polymeric solution which, through electrospinning, gave a biodegradable material with optimal mechanical features and the capacity to allow cell adhesion. In this paper we report the in-vivo application on a murine animal model of two electrospun biodegradable materials, specifically designed to create tubular structures. In one case PHEA-PLA was co-spun with silk fibroin (Fibro-PHEAPLA) by a parallel electrospinning process to obtain a scaffold with two different polymeric fibers. In the other case, PHEA-PLA was mixed with polycaprolactone (PCLPHEA-PLA) to obtain a hybrid fibers scaffold. The in-vitro assay showed fibroblast colonizatio…
CCDC 1421130: Experimental Crystal Structure Determination
2015
Related Article: Adrien T. Normand, Constantin G. Daniliuc, Birgit Wibbeling, Gerald Kehr, Pierre Le Gendre, and Gerhard Erker|2015|J.Am.Chem.Soc.|137|10796|doi:10.1021/jacs.5b06551
PHEA-graft-polybutylmethacrylate copolymer microparticles for delivery of hydrophobic drugs.
2012
Abstract Polymeric microparticles encapsulating two model hydrophobic drugs, beclomethasone dipropionate (BDP) and flutamide (FLU) were prepared by using the high pressure homogenization-solvent evaporation method starting from a oil-in-water emulsion. For the preparation of polymeric microparticles a α,β-poly(N-2-hydroxyethyl)- d , l -aspartamide (PHEA) graft copolymer with comb like structure was properly synthesized via grafting from atom transfer radical polymerization (ATRP) technique, by using two subsequent synthetic steps. In the first step a polymeric multifunctional macroinitiator was obtained by the conjugation of a proper number of 2-bromoisobutyryl bromide (BIB) residues to the…
Nano into Micro Formulations of Tobramycin for the Treatment of Pseudomonas aeruginosa Infections in Cystic Fibrosis.
2017
Here, nano into micro formulations (NiMs) of tobramycin for the treatment of Pseudomonas aeruginosa airway infections in cystic fibrosis (CF) are described. NiMs were produced by spray drying a solution containing polymers or sugars and a nanometric polyanion–tobramcyin complex (PTC), able to achieve a prolonged antibiotic release. NiMs properties were compared to TOBIPodhaler(Novartis), the only one commercially available dry powder inhalatory formulation based on porous microparticles. Produced NiMs showed adequate characteristics for pulmonary administration, as spherical shape, micrometric size, and high cytocompatibility toward human bronchial epithelial cells. Contrarily to TOBIPodhal…
Nanofibrillar scaffold resists to bile and urine action: experiences in pigs
2020
Biomaterial-based-scaffolds’ functions are to replace anatomical and functional features loss of an injured tissue. They can replace native tissue after their reabsorption. Material and methods. In our experimental procedures we utilized the PHEA-PLA+PCL scaffold in 2 female pigs to assess its resistance to bile and urine. Results. Both pigs survived to surgical procedures. After a month fibres appeared unchanged in term of form and dimension at electronic microscopy. Cells and ECM factors were founded inside the scaffold in a microscopical evaluation. Conclusion. Planar and tubular scaffolds were colonized by cells and extracellular matrix elements. The study conducted on pig suggested tha…
Carcass Characteristics, Meat Quality and Nutritional Profile of Pheasant, Quail and Guinea Fowl
2019
Over the last decade, there has been a growing interest in meat from non-conventional animal species, which have a deep-rooted tradition of consumption in some countries. Nowadays modern society have a purchase behaviour based on food safety, nutritional composition, taste/flavour, health aspects of foods and price. The consumption of traditional meat at this time is stagnating and consumers are looking for other alternative types of meats. In this context, this chapter tackles three alternative poultry breeds pheasant (Phasianus colchicus), quail (Coturnix coturnix japonica) and Guinea fowl (Numida meleagris), which have a great potential and demand in markets of western countries. Despite…