Search results for "PID"
showing 10 items of 11585 documents
TALPID3/KIAA0586 Regulates Multiple Aspects of Neuromuscular Patterning During Gastrointestinal Development in Animal Models and Human
2021
TALPID3/KIAA0586 is an evolutionary conserved protein, which plays an essential role in protein trafficking. Its role during gastrointestinal (GI) and enteric nervous system (ENS) development has not been studied previously. Here, we analyzed chicken, mouse and human embryonic GI tissues with TALPID3 mutations. The GI tract of TALPID3 chicken embryos was shortened and malformed. Histologically, the gut smooth muscle was mispatterned and enteric neural crest cells were scattered throughout the gut wall. Analysis of the Hedgehog pathway and gut extracellular matrix provided causative reasons for these defects. Interestingly, chicken intra-species grafting experiments and a conditional knockou…
Development of New Targeted Inulin Complex Nanoaggregates for siRNA Delivery in Antitumor Therapy.
2021
Here, a novel strategy of formulating efficient polymeric carriers based on the already described INU-IMI-DETA for gene material whose structural, functional, and biological properties can be modulated and improved was successfully investigated. In particular, two novel derivatives of INU-IMI-DETA graft copolymer were synthesized by chemical functionalisation with epidermal growth factor (EGF) or polyethylenglycol (PEG), named INU-IMI-DETA-EGF and INU-IMI-DETA-PEG, respectively, in order to improve the performance of already described “inulin complex nanoaggregates” (ICONs). The latter were thus prepared by appropriately mixing the two copolymers, by varying each component from 0 to 100 wt%…
Valorization of Side Stream Products from Sea Cage Fattened Bluefin Tuna (Thunnus thynnus): Production and In Vitro Bioactivity Evaluation of Enriche…
2022
The valorization of side streams from fishery and aquaculture value-chains is a valuable solution to address one of the challenges of the circular economy: turning wastes into profit. Side streams produced after filleting of sea cage fattened bluefin tuna (Thunnus thynnus) were analyzed for proximate composition and fatty acid profile to evaluate the possibility of producing tuna oil (TO) as a valuable source of ω-3 polyunsaturated fatty acids (PUFA) and testing its bioactivity in vitro. Ethyl esters of total fatty acids (TFA), obtained from TO, were pre-enriched by urea complexation (PUFA-Ue) and then enriched by short path distillation (SPD) up to almost 85% of the PUFA fraction (PU…
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
2009
We conducted meta-analyses of genome-wide association studies (GWAS) for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a novel locus for AF (ZFHX3, rs2106261, risk ratio [RR]=1.19; P=2.3×10−7), an association that was replicated in the German AF Network (odds ratio=1.44; P=1.6×10−11). Combining the discovery and replication results, rs2106261 was significantly associated with AF (RR=1.25; P=1.8×10−15).
Maturation of Epidermal Langerhans Cells In Vitro Is Accompanied by Downregulation of 4F2 (CD98) as Determined by Differential Display
1998
Following short-term culture, Langerhans cells mature morphologically and functionally into potent immunostimulatory cells. As regulation of gene expression accompanies this maturation process, it is likely that differentially expressed genes are involved in the maturation events. Using the recently described method of differential display, we generated cDNA expression patterns starting with mRNA of murine epidermal Langerhans cells isolated either directly (fLC) or following 3 d cultivation (cLC). Five hundred putative differentially expressed cDNA fragments were recovered from the gel. For a part of the fragments differential expression was confirmed by dot blot and Southern hybridization…
Slavinājuma konstruējums Plīnija Jaunākā darbā “Panegyricus ad Traianum”
2016
Grīnberga J. Slavinājums konstruējums Plīnija Jaunākā darbā: „Panegyricus ad Traianum”: bakalaura darbs. Rīga: LU, 2016. 52 lpp., 59.bibl. nos. Šī darba mērķis ir izpētīt, kā tiek īstenots slavinājuma konstruējums Plīnija Jaunākā Panegīrikā. Darba uzdevumi: apzinot tulkojumus un oriģināltekstu, izanalizēt un novērtēt kompozicionālo un leksisko materiālu, kas darbā tiek plaši izmantots dažādās kategorijās. Iegūstot priekšstatu par slavinājuma nozīmi, uzbūvi un izpratni retorikas teorijas kontekstā. Teorētiskajā daļā apskatīta retorikas teorija epideiktiskās runas kontekstā un leksiski semantiskā lauka teorija, bet praktiskā daļa balstīta slavinājuma runas analīzē. Apkopojot rezultātus, ir se…
Atherosclerosis Development and Progression: The Role of Atherogenic Small, Dense LDL.
2022
Atherosclerosis is responsible for large cardiovascular mortality in many countries globally. It has been shown over the last decades that the reduction of atherosclerotic progression is a critical factor for preventing future cardiovascular events. Low-density lipoproteins (LDL) have been successfully targeted, and their reduction is one of the key preventing measures in patients with atherosclerotic disease. LDL particles are pivotal for the formation and progression of atherosclerotic plaques; yet, they are quite heterogeneous, and smaller, denser LDL species are the most atherogenic. These particles have greater arterial entry and retention, higher susceptibility to oxidation, as well a…
Les agglomérations celtiques pré-Conquête en Gaule du Centre-Est. Apport des travaux du PCR « agglomérations antiques de Bourgogne, Franche-Comté et …
2019
Depuis les années 1980, l'étude du fait urbain antique est l'une des questions les plus étudiée sur le territoire des dix départements formant le centre-est de la France. Le développement d'un programme collectif de recherche sur ce thème en 2012 a permis d'en dresser un nouvel inventaire et de rassembler une donnée souvent disparate. Ces travaux ont plus particulièrement porté attention aux phases initiales de mise en place du réseau urbain, en tentant, à l'aide de ces données et de nouvelles prospections, de disposer d'une vision évolutive des sites les plus marquants. Malgré les grandes difficultés méthodologiques et documentaires rencontrées, il apparaît assez nettement que la période a…
Refining the preconditions of a social licence to operate (SLO) : reflections on citizens’ attitudes towards mining in two Finnish regions
2016
The debate around the social licence to operate (SLO) has been lively in recent years. In its elementary forms, the SLO is interpreted as the social acceptance granted by a community to mineral exploration and mining activities. Our theoretical assumption is that the SLO as a concept is both case-specific and more general, contingent, among other things, upon public opinion. In this study, acceptance is considered as general and anticipatory in the sense that it can act as a precondition for individual SLOs. Our intention is to contribute especially to recent novel research focusing on the more general background and factors contributing to the SLO. Using survey data (N = 1064), we explore …
Health Promotion Interventions in Sports Clubs: Can We Talk About a Setting-Based Approach? A Systematic Mapping Review
2019
Many researchers and authorities have recognized the important role that sports clubs can play in public health. In spite of attempts to create a theoretical framework in the early 2000s, a thorough understanding of sports clubs as a setting for health promotion (HP) is lacking. Despite calls for more effective, sustainable, and theoretically grounded interventions, previous literature reviews have identified no controlled studies assessing HP interventions in sports clubs. This systematic mapping review details how the settings-based approach is applied through HP interventions in sports clubs and highlights facilitators and barriers for sports clubs to become health-promoting settings. In…