Search results for "PIDE"
showing 10 items of 6055 documents
A recommended practical approach to the management of target therapy and angiogenesis inhibitors cardiotoxicity: an opinion paper of the working grou…
2016
The US National Cancer Institute estimates that cardiotoxicity (CTX) from target therapy refers mostly to four groups of drugs: epidermal growth factor receptor 2 inhibitors, angiogenic inhibitors, directed Abelson murine leukemia viral oncogene homolog inhibitors, and proteasome inhibitors. The main cardiotoxic side-effects related to antiepidermal growth factor receptor 2 therapy are left ventricular systolic dysfunction and heart failure. Angiogenesis inhibitors are associated with hypertension, left ventricular dysfunction/heart failure, myocardial ischemia, QT prolongation, and thrombosis. Moreover, other agents may be related to CTX induced by treatment. In this study, we review the g…
Malocclusion characteristics amongst individuals with autism spectrum disorder: a systematic review and meta‑analysis
2022
Abstract Background To estimate the prevalence of malocclusion in individuals with autism spectrum disorders (ASD) and to assess the relationship between ASD and malocclusion. Methods We searched electronic databases including PubMed, Scopus, Web of Science, Cochrane, Embase, SciELO LILACS, Proquest, OpenGrey and Google Scholar. There were no language or publication dates restrictions. Two researchers independently performed selection, data extraction and quality assessment. Quality assessment and risk of bias were evaluated through the Newcastle–Ottawa scale and ROBINS-E tool. Meta-analyses using random effect models were used to estimate pooled measures of prevalence of malocclusion chara…
Sul culto dei betili a Mozia. A proposito di un cono sacro
2013
SENSIBILIZZAZIONE AD ANISAKIS IN CATEGORIE PROFESSIONALI ESPOSTE IN AMBITO OCCUPAZIONALE IN SICILIA
2017
INTRODUZIONE: La diffusione su larga scala del consumo di pesce crudo ha contribuito all’incremento di manifestazioni allergiche conseguenti al contatto col parassita del pesce Anisakis. Obiettivo dello studio è stato quello di stimare il rischio di contrarre allergie Anisakis-correlate in lavoratori del comparto ittico e della ristorazione. MATERIALI E METODI: È stato realizzato uno studio cross-sectional per stimare la prevalenza della sensibilizzazione ad Anisakis simplex (As) su un campione di 46 cuochi e/o addetti alla preparazione degli alimenti reclutati nella provincia di Palermo. A tutti i soggetti è stato somministrato un questionario clinico-anamnestico ed è stato effettuato un p…
Sindrome nefrosica e sepsi da Gram negativi in corso di strongiloidiasi: considerazioni su un caso in immigrato imunocompetente
2007
Strongyloidiasis is caused by a small intestinal nematode with a complex life cycle. In Italy the infection is endemic in rural areas of the Po Valley. The clinical syndrome of S. stercoralis encompasses a broad spectrum of symptoms and signs and, in the immunocompromised host, larvae can migrate to different organs and tissues. Also immune response seems to play a role in the pathogenesis of the disease. We report a case of strongyloidiasis complicated by Gram-negative sepsis and nephrotic syndrome in an immigrant from South America with a normal immune response. Whereas sepsis cleared up quickly, parasitic clearance was obtained only after treatment with ivermectin and nephrotic syndrome …
Study of the antitumor effect of inducible nitric oxide synthase in a breast cancer model : analysis of molecular mechanisms
2013
The anti -tumor effect of a lipid A, OM -174 (lipid portion of LPS) was studied in a model of breast cancer in mice. In vivo, OM- 174 increases the survival of mice whereas in vitro it is not toxic to cancer cells. OM -174 binds to TLR4 immune cells inducing the production of cytokines such as IFNγ. In vitro, the combination of IFNγ to lipid A is cytotoxic. The objective of this thesis is to analyze those molecular mechanisms. We have shown both in vitro and in vivo that the cytotoxicity of the lipid A / IFNγ is dependent of TLR4 and of the receptor for IFNγ, and the NOS II expression. We also showed that the radical species, NO and superoxide anion forming peroxynitrite play a crucial role…
Solvent-free microwave-assisted extraction of polyphenols from olive tree leaves: Antioxidant and antimicrobial properties
2017
International audience; Response surface methodology (RSM) and artificial neural networks (ANN) were evaluated and compared in order to decide which method was the most appropriate to predict and optimize total phenolic content (TPC) and oleuropein yields in olive tree leaf (Olea europaea) extracts, obtained after solvent-free microwave- assisted extraction (SFMAE). The SFMAE processing conditions were: microwave irradiation power 250-350 W, extraction time 2-3 min, and the amount of sample 5-10 g. Furthermore, the antioxidant and antimicrobial activities of the olive leaf extracts, obtained under optimal extraction conditions, were assessed by several in vitro assays. ANN had better predic…
Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011).
2013
Estudio hospitalario del vértigo y mareo: aspectos clínicos y radiológicos
2020
Esta tesis doctoral trabaja sobre pacientes remitidos a cualquier especialidad de un hospital sin unidad de otoneurología por los síntomas vértigo y mareo. En una primera parte se analizan sus características demográficas y clínicas y se evalúan las derivaciones con el fin de obtener datos que permitan mejorar la calidad asistencial. También se analizan las pruebas de imagen realizadas en los pacientes con vértigo y mareo, para poder determinar su utilidad y establecer recomendaciones. Las conclusiones se resumen en los siguientes puntos: En el hospital hay una tasa anual de 1,6 primeras visitas por cada 1000 habitantes debido a los síntomas vértigo y mareo. De todos los pacientes derivados…
2016
Background Transcatheter aortic valve implantation (TAVI) has become the treatment of choice in patients with severe aortic valve stenosis who are not eligible for operative replacement and an alternative for those with high surgical risk. Due to high age and smoking history in a high proportion of TAVI patients, suspicious findings are frequently observed in pre-procedural chest computer tomography (CCT).