Search results for "PIDE"
showing 10 items of 6055 documents
Further development of the β-lactamase MutaGen assay and evaluation by comparison with Ames fluctuation tests and theumu test
2005
A rapid, high-throughput bacterial mutagenicity test system has been developed (MutaGen test) that detects reversions of inactivating base-pair substitutions and frameshifts in a TEM-1 class A β-lactamase (ampicillinase) gene. To quickly and sensitively detect mutagens, the system utilises a series of plasmids that contain the mutated ampicillinase gene and the mucAB operon. Inactivating mutations in the ampicillinase gene include frameshifts integrated into repetitive GC-sequences and G-runs known to be mutagenic hot-spots, and base-pair substitutions inserted in or around the β-lactamase active site. Frameshift mutations completely inactivated the enzyme only when located downstream of th…
Confirmatory factor analysis of the proxy version of Kidscreen-27 and relationships between health-related quality of life dimensions and body mass i…
2020
Highlights • The full Kidscreen-27 should be used with caution for young children. • Physical activity was positively associated with physical well-being. • Body mass was negatively associated with physical well-being. • Compared to older children, the youngest may have more negative school experiences.
Exploring relationships between drought and epidemic cholera in Africa using generalised linear models
2021
Abstract Background Temperature and precipitation are known to affect Vibrio cholerae outbreaks. Despite this, the impact of drought on outbreaks has been largely understudied. Africa is both drought and cholera prone and more research is needed in Africa to understand cholera dynamics in relation to drought. Methods Here, we analyse a range of environmental and socioeconomic covariates and fit generalised linear models to publicly available national data, to test for associations with several indices of drought and make cholera outbreak projections to 2070 under three scenarios of global change, reflecting varying trajectories of CO2 emissions, socio-economic development, and population gr…
A Genome-wide Association Study of Early-onset Breast Cancer Identifies PFKM as a Novel Breast Cancer Gene and Supports a Common Genetic Spectrum for…
2014
Abstract Early-onset breast cancer (EOBC) causes substantial loss of life and productivity, creating a major burden among women worldwide. We analyzed 1,265,548 Hapmap3 single-nucleotide polymorphisms (SNP) among a discovery set of 3,523 EOBC incident cases and 2,702 population control women ages ≤ 51 years. The SNPs with smallest P values were examined in a replication set of 3,470 EOBC cases and 5,475 control women. We also tested EOBC association with 19,684 genes by annotating each gene with putative functional SNPs, and then combining their P values to obtain a gene-based P value. We examined the gene with smallest P value for replication in 1,145 breast cancer cases and 1,142 control …
La Prevalenza del Dolore Cronico Non Oncologico nell’Adulto e Patologie Associate: Una revisione narrativa
2013
Introduzione: Il dolore cronico non oncologico rappresenta un problema sanitario sottostimato dal punto di vista epidemiologico ed in termini di salute pubblica. Esso è una malattia in senso stretto, e rappresenta una delle maggiori motivazioni per cui i soggetti si rivolgono ai servizi sanitari. La grandezza del fenomeno si esprime in termini di sofferenza umana e di costi sociali. L’obiettivo di questa revisione è quello di identificare le cause e la prevalenza del dolore cronico non oncologico nei soggetti adulti. Metodi: E’ stata realizzata una revisione della letteratura dal 1998 al 2012 utilizzando le emeroteche virtuali partendo dalle banche dati (Pub-Med, CINHAL). È stata effettuata…
Psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features-A systematic review of randomized clinical trials …
2021
Objectives To review the effectiveness of psychological therapies for adolescents with borderline personality disorder (BPD) or BPD features. Methods We included randomized clinical trials on psychological therapies for adolescents with BPD and BPD features. Data were extracted and assessed for quality according to Cochrane guidelines, and summarized as mean difference (MD) with 95% confidence intervals (CI) for continuous data and as Odds ratios (OR) with 95% CI for dichotomous data. Risk of bias was assessed using Cochrane’s risk of bias tool for each domain. When possible, we pooled trials into meta-analyses, and used Trial Sequential Analysis (TSA) to control for random errors. Quality…
Étude des cancers secondaires dans les lymphomes non hodgkiniens au sein d’un registre : impact du rituximab
2014
Introduction Le nombre de survivants d’un lymphome folliculaire (LF) ou d’un lymphome B diffus a grandes cellules (LBDGC) est en augmentation. L’etude des cancers secondaires est un enjeu important de sante publique. Le risque lie a la chimiotherapie conventionnelle est bien decrit, mais peu de donnees existent pour le rituximab. Methode Etude retrospective au sein du Registre des hemopathies malignes de Cote d’or (RHEMCO) comparant l’incidence des cancers secondaires avant/apres l’introduction du rituximab, chez les patients ayant un LF ou un LBDGC diagnostique entre 1990 et 2010. La comparaison du taux de cancers secondaires observe au taux attendu dans la population francaise a ete expri…
Risque augmenté de ré-hospitalisation chez les personnes atteintes de diabète de type 1 et de schizophrénie
2019
Introduction La morbidite et mortalite associees au diabete comme a la schizophrenie suggerent que leur combinaison puisse generer de graves problemes. L’objectif de l’etude etait d’estimer le risque de re-hospitalisation pour complications aigues du diabete et tentative de suicide a trois ans chez des personnes atteintes de diabete et de schizophrenie. Methodes A partir des donnees nationales d’hospitalisation, l’etude en population s’est interessee aux personnes âgees de 15 a 35 ans pour lesquelles une hospitalisation mentionnait un diabete de type 1, entre 2009 et 2012. Pour identifier les personnes atteintes de schizophrenie, un code correspondant a ete recherche pendant ou dans les deu…
Mesure de la qualité des soins à partir de la base de données nationale du PMSI. Étude de la mortalité hospitalière après résections pulmonaires pour…
2016
Introduction En 2009, les centres prenant en charge des cancers ont ete soumis a autorisation suite au premier plan cancer. Cinq annees plus tard, il nous paraissait interessant de connaitre l’impact de cette nouvelle organisation. L’objectif est d’estimer l’effet periode et d’evaluer l’influence du volume d’activite sur la mortalite. Methodes De la base de donnees PMSI ont ete extraits pour tous les patients ayant eu une resection pulmonaire pour cancer bronchique. Les caracteristiques des centres comprennent le volume d’activite annuel et le type d’etablissement : publiques non universitaires, prives et CHU. L’indicateur de qualite utilise est la mortalite hospitaliere definie comme tout …
L’échantillon généraliste des bénéficiaires : un outil pour l’évaluation du risque vaccinal ?
2014
Introduction Les bases de donnees medico-administratives sont de plus en plus utilisees pour evaluer le risque vaccinal. L’echantillon generaliste des beneficiaires (EGB) a ete cree a partir de celle de l’Assurance-maladie par echantillonnage au 1/97 e de la population francaise. L’objectif de l’etude est de calculer pour differentes associations effet indesirable/vaccin un nombre de cas necessaires et de comparer ces effectifs avec ceux disponibles dans l’EGB. Methodes L’analyse en serie de cas est une approche frequemment utilisee pour ce type d’etude. Les effectifs ont ete calcules dans ce cadre, avec et sans prise en compte de l’effet âge. Pour l’association convulsion febrile (CF)/vacc…