Search results for "PIP"
showing 10 items of 1156 documents
Hydraulic vs. Electric: A Review of Actuation Systems in Offshore Drilling Equipment
2016
This article presents a survey on actuation systems encountered in offshore drilling applications. Specifically, it focuses on giving a comparison of hydraulic and electric drivetrains along with detailed explanations of their advantages and drawbacks. A significant number of industrial case studies is examined in addition to the collection of academic publications, in order to accurately describe the current market situation. Some key directions of research and development required to satisfy increasing demands on powertrains operating offshore are identified. The impact of the literature and application surveys is further strengthened by benchmarking two designs of a full-scale pipe handl…
A survey of the epiphytic bryophyte flora of the Rif and Tazzeka Mountains (northern Morocco)
2005
SUMMARY The catalogue of the epiphytic bryophyte flora of the Rif Mountains includes a total of 72 taxa, of which 66 are mosses and six are liverworts. Some new records are provided: Hypnum resupinatum and Tortula israelis, new to northern Africa, Antitrichia curtipendula and Cryphaea heteromalla, new to Morocco, and Dicranoweisia cirrata, Isothecium alopecuroides and Orthotrichum macrocephalum ,n ew to the Rif Mountains. Epiphytic communities in the different forest types have been analysed, with the conclusion that altitude and humidity are the main factors that determine their composition. The epiphytic stratum is best developed at the highest altitudes on the Principal chain and Tazzeka…
Numerical simulation of reciprocating turbulent flow in a plane channel
2009
Direct numerical simulation results were obtained for oscillatory flow with zero time mean (reciprocating flow) in a plane channel using a finite volume method, Crank-Nicolson time stepping and central approximation of the advection terms. A pressure gradient varying co-sinusoidally in time was imposed as the forcing term, and its frequency and amplitude were made to vary so as to span a range of regimes from purely laminar to fully turbulent. For the limiting cases of reciprocating laminar flow and steady-state turbulent flow, numerical results were validated against analytical solutions and classic experimental literature data, respectively. For general reciprocating flows, predictions we…
On the influence of gravitational and centrifugal buoyancy on laminar flow and heat transfer in curved pipes and coils
2015
Abstract The effects of gravitational and centrifugal buoyancy on laminar flow and heat transfer in curved and helical pipes were investigated by numerical simulation. Six dimensionless numbers characterizing the problem were identified, and an analysis was conducted on the possible combinations of signs of the gravitational and centrifugal buoyancy effects. Two distinct Richardson numbers were introduced in order to quantify the importance of the two types of buoyancy, and it was shown that, in the case of heating from the wall, a maximum realizable value of the centrifugal Richardson number exists which is a linear function of the curvature δ (ratio of pipe radius a to curvature radius c)…
A study of turbulent heat transfer in curved pipes by numerical simulation
2013
Abstract Turbulent heat transfer in curved pipes was studied by numerical simulation. Two curvatures δ (pipe radius a/curvature radius c) were considered, 0.1 and 0.3; results were also obtained for a straight pipe (δ = 0) for comparison purposes. A tract of pipe 5 diameters in length was chosen as the computational domain and was discretized by finite volume multiblock-structured grids of ∼5.3 × 106 hexahedral cells. Fully developed conditions were assumed; the friction velocity Reynolds number was 500, corresponding to bulk Reynolds numbers between 12 630 and ∼17 350 according to the curvature, while the Prandtl number was 0.86 (representative of saturated liquid water at 58 bar). Simulat…
Synthesis and evaluation of (S)-2-(2-[18F]fluoroethoxy)-4-([3-methyl-1-(2-piperidin-1-yl-phenyl)-butyl-carbamoyl]-methyl)-benzoic acid ([18F]repaglin…
2004
18F-labeled non-sulfonylurea hypoglycemic agent (S)-2-(2-[(18)F]fluoroethoxy)-4-((3-methyl-1-(2-piperidin-1-yl-phenyl)-butylcarbamoyl)-methyl)-benzoic acid ([(18)F]repaglinide), a derivative of the sulfonylurea-receptor (SUR) ligand repaglinide, was synthesized as a potential tracer for the non-invasive investigation of the sulfonylurea 1 receptor status of pancreatic beta-cells by positron emission tomography (PET) in the context of type 1 and type 2 diabetes. [(18)F]Repaglinide could be obtained in an overall radiochemical yield (RCY) of 20% after 135 min with a radiochemical purity higher than 98% applying the secondary labeling precursor 2-[(18)F]fluoroethyltosylate. Specific activity w…
P-Glycoprotein Influence on the Brain Uptake of a 5-HT2A Ligand: [18F]MH.MZ
2010
<i>Background/Aims:</i> The serotonergic system, especially the 5-HT<sub>2A</sub> receptor, is involved in various diseases and conditions. We have recently developed a new [<sup>18</sup>F]-5-HT<sub>2A</sub> receptor ligand using an analogue, MDL 100907, as a basis for molecular imaging with positron emission tomography. This tracer, [<sup>18</sup>F]MH.MZ, has been shown to be an adequate tool to visualize the 5-HT<sub>2A</sub> receptors in vivo. However, [<sup>18</sup>F]altanserin, similar in chemical structure, is a substrate of efflux transporters, such as P-glycoprotein (P-gp), of the blood-brain barrier…
SYNTHESIS AND IN VITRO AFFINITIES OF VARIOUS MDL 100907 DERIVATIVES AS POTENTIAL 18F-RADIOLIGANDS FOR 5-HT2A RECEPTOR IMAGING WITH PET
2008
Radiolabelled piperidine derivatives such as [(11)C]MDL 100907 and [(18)F]altanserin have played an important role in diagnosing malfunction in the serotonergic neurotransmission. A variety of novel piperidine MDL 100907 derivatives, possible to label with (18)F-fluorine, were synthesized to improve molecular imaging properties of [(11)C]MDL 100907. Their in vitro affinities to a broad spectrum of neuroreceptors and their lipophilicities were determined and compared to the clinically used reference compounds MDL 100907 and altanserin. The novel compounds MA-1 (53) and (R)-MH.MZ (56) show K(i)-values in the nanomolar range towards the 5-HT(2A) receptor and insignificant binding to other 5-HT…
Total synthesis and evaluation of [18F]MHMZ.
2007
Radiochemical labeling of MDL 105725 using the secondary labeling precursor 2-[(18)F]fluoroethyltosylate ([(18)F]FETos) was carried out in yields of approximately 90% synthesizing [(18)F]MHMZ in a specific activity of approximately 50MBq/nmol with a starting activity of approximately 3GBq. Overall radiochemical yield including [(18)F]FETos synthon synthesis, [(18)F]fluoroalkylation and preparing the injectable [(18)F]MHMZ solution was 42% within a synthesis time of approximately 100 min. The novel compound showed excellent specific binding to the 5-HT(2A) receptor (K(i)=9.0 nM) in vitro and promising in vivo characteristics.
Chemical composition of the essential oil from different vegetative parts of Foeniculum vulgare subsp. piperitum (Ucria) Coutinho (Umbelliferae) grow…
2021
In the present study, the chemical compositions of the essential oils from roots, stems, leaves and fruits of Foeniculum vulgare subsp. piperitum collected in Sicily were evaluated by GC and GC-MS. The main components of the roots were terpinolene (33.15%), gamma-terpinene (12.18%) and fenchyl acetate (11.23%). Stems and leaves were very rich in alpha-phellandrene (36.85% and 41.59%, respectively) and beta-phellandrene (19.68% and 25.79%, respectively), whereas the main components of fruits were terpinolene (20.10%) and limonene (17.84%)These results were compared with those of the EOs of the same vegetative parts of Foeniculum vulgare subsp. vulgare, collected in the same station and in th…