Search results for "PLASMA"
showing 10 items of 4043 documents
Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model.
2012
Background The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases. One solution for overcoming this barrier is a transport by binding of these drugs to surface-modified nanoparticles. Especially apolipoprotein E (ApoE) appears to play a major role in the nanoparticle-mediated drug transport across the BBB. However, at present the underlying mechanism is incompletely understood. Methodology/Principal Findings In this study, the uptake of the ApoE-modified nanoparticles into the brain capillary endothelial cells was investigated to differentiate between active and passive uptake mechanism by flow cytome…
Genetic polymorphisms affecting the phenotypic expression in familial hypercholesterolemia
2004
The clinical expression of heterozygous familial hypercholesterolemia (FH) is highly variable even in patients carrying the same LDL receptor (LDL-R) gene mutation. This variability might be due to environmental factors as well as to modifying genes affecting lipoprotein metabolism. We investigated Apo E (2, 3, 4), MTP (-493G/T), Apo B (-516C/T), Apo A-V (-1131T/C), HL (-514C/T and -250G/A), FABP-2 (A54T), LPL (D9N, N291S, S447X) and ABCA1 (R219K) polymorphisms in 221 unrelated FH index cases and 349 FH relatives with defined LDL-R gene mutations. We found a significant and independent effect of the following polymorphisms on: (i) plasma LDL-C (Apo E, MTP and Apo B); (ii) plasma HDL-C (HL, …
Temperature‐Responsive Nanoparticles Enable Specific Binding of Apolipoproteins from Human Plasma
2021
Apolipoproteins are an important class of proteins because they provide a so-called stealth effect to nanoparticles. The stealth effect on nanocarriers leads to a reduced unspecific uptake into immune cells and thereby to a prolonged blood circulation time. Herein, a novel strategy to bind apolipoproteins specifically on nanoparticles by adjusting the temperature during their incubation in human plasma is presented. This specific binding, in turn, allows a control of the stealth behavior of the nanoparticles. Nanoparticles with a well-defined poly(N-isopropylacrylamide) shell are prepared, displaying a reversible change of hydrophobicity at a temperature around 32 °C. It is shown by label-f…
Numerical Study of Blow-Up Mechanisms for Davey-Stewartson II Systems
2018
We present a detailed numerical study of various blow-up issues in the context of the focusing Davey-Stewartson II equation. To this end we study Gaussian initial data and perturbations of the lump and the explicit blow-up solution due to Ozawa. Based on the numerical results it is conjectured that the blow-up in all cases is self similar, and that the time dependent scaling is as in the Ozawa solution and not as in the stable blow-up of standard $L^{2}$ critical nonlinear Schr\"odinger equations. The blow-up profile is given by a dynamically rescaled lump.
Time-course changes of plasma lipid levels and lipoprotein pattern after feeding in cultured sea bass, Dicentrarchus labrax L.
1988
Results of a study of plasma lipids levels and lipoprotein pattern modification during digestion in sea bass indicate that, after feeding, non-esterified fatty acids are rapidly delivered in plasma, while triglycerides reach a maximum concentration only 24 h later. The time-course change of the lipoprotein pattern shows a relationship between their concentration and the lipid class carried.
Reduced protein adsorption on plastics via direct plasma deposition of triethylene glycol monoallyl ether
1997
The direct plasma-induced deposition of tri(ethylene glycol) monoallyl ether is reported. RF plasma polymerization of this monomer was carried out under both continuous wave (CW) and pulsed plasma operation. The major focus of this work was optimization of the degree of retention of the C-O-C bonds of the starting monomer during the deposition process. This successfully was accomplished using low RF power during the CW runs and low RF duty cycles during the pulsed plasma experiments. Spectroscopic analysis of the plasma films revealed a strong dependence of film composition on the RF power and duty cycles employed. In particular, an unusually high level of film chemistry compositional contr…
Comparison between probe stagnation point heat flux measurements and correlation formulas in SCIROCCO plasma wind tunnel tests
2012
A large part of the SCIROCCO Arc Heater Performance Map has been investigated. The heat flux measurements at the stagnation point of t he facility Calibratio Probe have been used to find an experimental fit. Such a formula ha s been compared with the predictions of the De Filippis-Serpico equation and the well known Fay-Riddell formula. Finally the experimental fit has been also compared with the Sa gner-Verant formula obtained at the ONERA F4 hypersonic plasma wind tunnel.
PHYSICO-CHEMICAL CHARACTERIZATION OF THE ACQUALADRONE ROSTRUM
2011
The archaeological discovery of the Acqualadrone rostrum (an offensive naval weapon mounted on the prow at the waterline), off the Italian coast near Messina in 2008, has led to the need for scientific research in order to plan the conservation treatment of this artefact. The discovery is exceptional because of the presence of a wooden section from the original ship. This paper describes the physico-chemical characterization of a metallic and two wooden samples by inductively coupled plasma – optical emission spectroscopy, inductively coupled plasma – mass spectrometry, Fourier transform infrared spectroscopy, 13 C{ 1 H} cross-polarization magic angle spinning NMR spectroscopy, energy-dispe…
Biological mineral content in Iberian skeletal cremains for control of diagenetic factors employing multivariate statistics
2013
Abstract The aim of this study was to define a strategy for a correct selection of bone samples by employing inductively coupled plasma optical emission spectroscopy (ICP-OES) for reconstructing the biological mineral content in bones through the determination of major elements, trace elements and Rare Earth Elements (REE, lanthanides) in skeletal cremains of ancient Iberians (III–II B.C), discovered in the Necropolis of Corral de Saus (Moixent, Valencia) between 1972 and 1979. The biological mineral content was determined taking into account diagenetic factors. A control method for a better reading of results was applied. To explore large geochemical datasets and to reduce the number of va…
Studies of the bromine spectrum and determination of transition probabilities for Br I and Br II lines
1999
In a wall-stabilized cascade arc at atmospheric pressure in mixtures of argon and bromine vapors thermal plasmas were generated. Arc currents between 25 and 60 A were used. Applying a spectrometer of medium dispersion, equipped with an optical multichannel analyzer (CCD detector), the spectra of neutral and singly ionized bromine in the range between 3300 and 10400 A were recorded. Line intensity measurements, corrected for self-absorption, at different operating conditions of the arc, were performed. A complete set of Br I transitions (5 lines) originating from a common upper level (branching fractions) was measured. In the case of the Br II spectrum intensities of 14 lines were determined…