Search results for "PLE"

DAC 6, efficacia dell’accertamento tributario e trasparenza: fino a che punto sono legittimi i doveri di disclosure?

2021

I molteplici interventi sull’originaria struttura della direttiva DAC hanno comportato un notevole ampliamento degli obblighi di informazione fiscalmente rilevanti tanto sotto il profilo soggettivo (ampliamento della platea degli obbligati), quanto sotto quello oggettivo (ampliamento degli obblighi). Ciò induce, in prima battuta, a chiedersi quali possano essere i beni o interessi giuridici tutelati dallo scambio automatico di informazioni fiscalmente rilevanti nel contesto internazionale. Ma induce altresì a domandarsi entro quale misura la tutela di quei beni ed interessi possa legittimare un obbligo di disclosure che attiene non ad un piano domestico dei rapporti fra l’obbligato ed il pr…

Subjective memory decline and objectively assessed memory ability among older people : a cross-sectional study

2012

Objective: The purpose of this study was to explore whether the objectively assessed memory is correlated with the self-rated memory, and does the self-rated memory ability differ among ages. Methods: Data was obtained from the Evergreen project. A total of 558 people aged between 72 and 92 years were included in the current study. In order to examine the complexity of the relationships between self-rated memory and objective memory ability of the older people, cognitive functioning was assessed by metacognitive self-evaluations and Mini-D cognitive screening test. Main Results: Mini-D sum score and self-rated memory decline was significantly correlated (p=34). No significant age difference…

DESMILS : a decision support approach for multi-item lot sizing using interactive multiobjective optimization

2023

AbstractWe propose a decision support approach, called DESMILS, to solve multi-item lot sizing problems with a large number of items by using single-item multiobjective lot sizing models. This approach for making lot sizing decisions considers multiple conflicting objective functions and incorporates a decision maker’s preferences to find the most preferred Pareto optimal solutions. DESMILS applies clustering, and items in one cluster are treated utilizing preferences that the decision maker has provided for a representative item of the cluster. Thus, the decision maker provides preferences to solve the single-item lot sizing problem for few items only and not for every item. The lot sizes …

Improving Hand Hygiene Behavior Using a Novel Theory-Based Intervention During the COVID-19 Pandemic

2022

Abstract Background Promoting the adoption of personal hygiene behaviors known to reduce the transmission of COVID-19, such as avoiding touching one’s face with unwashed hands, is important for limiting the spread of infections. Purpose We aimed to test the efficacy of a theory-based intervention to promote the avoidance of touching one’s face with unwashed hands to reduce the spread of COVID-19. Methods We tested effects of an intervention employing imagery, persuasive communication, and planning techniques in two pre-registered studies adopting randomized controlled designs in samples of Australian (N = 254; Study 1) and US (N = 245; Study 2) residents. Participants were randomly assigned…

Transformacja połączeń rtęć - substancje humusowe przy udziale Pleurotus ostreatus

2013

Branched-Chain Amino Acid Deprivation Decreases Lipid Oxidation and Lipogenesis in C2C12 Myotubes

2022

Impaired lipid metabolism is a common risk factor underlying several metabolic diseases such as metabolic syndrome and type 2 diabetes. Branched-chain amino acids (BCAAs) that include valine, leucine and isoleucine have been proven to share a role in lipid metabolism and hence in maintaining metabolic health. We have previously introduced a hypothesis suggesting that BCAA degradation mechanistically connects to lipid oxidation and storage in skeletal muscle. To test our hypothesis, the present study examined the effects of BCAA deprivation and supplementation on lipid oxidation, lipogenesis and lipid droplet characteristics in murine C2C12 myotubes. In addition, the role of myotube contract…

The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu

2014

Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…

Problemas enrevesados

2014

Se revisan los diversos modos de razonamiento de las personas con el ánimo de llegar a ser deliberadamente consciente de ellos y poder alcanzar así los niveles más valiosos de racionalidad para resolver los problemas que verdaderamente tienen interés, los mal estructurados.

Towards a FAIR Sharing of Scientific Experiments: Improving Discoverability and Reusability of Dielectric Measurements of Biological Tissues

2018

Metafora ed Analogia in Didattica della Matematica

2014

This paper is a report that concerns two experiments that I proposed in nine secondary school classes (pupils from fourteen to eighteen years old) in order to test some hypotesis concerning the use of metaphor during teaching-learning processes. I begin by analyzing the different significances of the concepts of metaphor and analogy that can be found in literature. Then I try to frame these concepts within the framework of semiotic mediation. I show some excerpts taken from the experimentations, and I try to interpret some of pupil’s utterances (words, gestures) as metaphors which offer to the teacher a possible way (by analogies) to introduce mathematical contents. I conclude with some ope…