Search results for "PLE"
showing 10 items of 22773 documents
Computational Structures and SAPT Interaction Energies of HXeSH···H2Y (Y=O or S) Complexes
2018
Ab initio calculations of the structures, vibrational spectra and supermolecular and symmetry-adapted perturbation theory (SAPT) interaction energies of the HXeOH and HXeSH complexes with H2O and H2S molecules are presented. Two minima already reported in the literature were reproduced and ten new ones were found together with some transition states. All complexes show blue shift in Xe&ndash
Modification of a commercial atomic force microscopy for low-noise, high-resolution frequency-modulation imaging in liquid environment.
2011
A key issue for high-resolution frequency-modulation atomic force microscopy imaging in liquids is minimizing the frequency noise, which requires a detailed analysis of the corresponding noise contributions. In this paper, we present a detailed description for modifying a commercial atomic force microscope (Bruker MultiMode V with Nanoscope V controller), aiming at atomic-resolution frequency-modulation imaging in ambient and in liquid environment. Care was taken to maintain the AFMs original stability and ease of operation. The new system builds upon an optimized light source, a new photodiode and an entirely new amplifier. Moreover, we introduce a home-built liquid cell and sample holder …
Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules?
2021
Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Ideally, biomarkers should also be non-invasive and cost-effective. This review aims to focus on the usefulness and limitations of electroencephalography (EEG) in the search for Alzheimer’s disease (AD) biomarkers. The main aim of this article is to review the evolution of the most used biomarkers in AD and the need for new peripheral and, ideally, non-invasive b…
Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts
2014
The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…
The rs2294918 E434K variant modulates PNPLA3 expression and liver damage.
2015
The PNPLA3 rs738409 polymorphism (I148M) is a major determinant of hepatic fat and predisposes to the full spectrum of liver damage in nonalcoholic fatty liver disease (NAFLD). Aim of this study was to evaluate whether additional PNPLA3 coding variants contribute to NAFLD susceptibility, first in individuals with contrasting phenotypes (with early onset NAFLD vs. very low aminotransferases), and then in a large validation cohort. Rare PNPLA3 variants were not detected by sequencing coding regions and intron-exon boundaries either in 142 patients with early-onset NAFLD, nor in 100 healthy individuals with ALT A polymorphism (E434K sequence variant) was over-represented in NAFLD (adjusted p=0…
Phase-delayed laser diode array allows ultrasonic guided wave mode selection and tuning
2013
Selecting and tuning modes are useful in ultrasonic guided wave non-destructive testing (NDT) since certain modes at various center frequencies are sensitive to specific types of defects. Ideally one should be able to select both the mode and the center frequency of the launched waves. We demonstrated that an affordable laser diode array can selectively launch either the S0 or A0 ultrasonic wave mode at a chosen center frequency into a polymer plate. A fiber-coupled diode array (4 elements) illuminated a 2 mm thick acrylic plate. A predetermined time delay matching the selected mode and frequency was employed between the output of the elements. The generated ultrasound was detected by a 215…
Very narrow quantum OBDDs and width hierarchies for classical OBDDs
2014
In the paper we investigate a model for computing of Boolean functions - Ordered Binary Decision Diagrams (OBDDs), which is a restricted version of Branching Programs. We present several results on the comparative complexity for several variants of OBDD models. - We present some results on the comparative complexity of classical and quantum OBDDs. We consider a partial function depending on a parameter k such that for any k > 0 this function is computed by an exact quantum OBDD of width 2, but any classical OBDD (deterministic or stable bounded-error probabilistic) needs width 2 k+1. - We consider quantum and classical nondeterminism. We show that quantum nondeterminism can be more efficien…
Wiener-Granger Causality in Network Physiology with Applications to Cardiovascular Control and Neuroscience
2016
Since the operative definition given by C. W. J. Granger of an idea expressed by N. Wiener, the Wiener–Granger causality (WGC) has been one of the most relevant concepts exploited by modern time series analysis. Indeed, in networks formed by multiple components, working according to the notion of segregation and interacting with each other according to the principle of integration, inferring causality has opened a window on the effective connectivity of the network and has linked experimental evidences to functions and mechanisms. This tutorial reviews predictability improvement, information-based and frequency domain methods for inferring WGC among physiological processes from multivariate…
Non-homogeneous Dirichlet problems with concave-convex reaction
2022
The variational methods are adopted for establishing the existence of at least two nontrivial solutions for a Dirichlet problem driven by a non-homogeneous differential operator of p-Laplacian type. A large class of nonlinear terms is considered, covering the concave-convex case. In particular, two positive solutions to the problem are obtained under a (p -1)-superlinear growth at infinity, provided that a behaviour less than (p -1)-linear of the nonlinear term in a suitable set is requested.
Solutions with sign information for nonlinear Robin problems with no growth restriction on reaction
2019
We consider a parametric nonlinear Robin problem driven by a nonhomogeneous differential operator. The reaction is a Carathéodory function which is only locally defined (that is, the hypotheses concern only its behaviour near zero). The conditions on the reaction are minimal. Using variational tools together with truncation, perturbation and comparison techniques and critical groups, we show that for all small values of the parameter λ > 0, the problem has at least three nontrivial smooth solutions, two of constant sign and the third nodal.