Search results for "PLUS"
showing 10 items of 248 documents
The significance of the concept of sin for bioethics.
2005
After a period during which the theological categories of sin and forgiveness were ignored or trivialized, presently these notions are being rediscovered. What could their impact be on bioethics, either in the narrow sense of medical ethics, or in the more encompassing sense of the ethics of the life sciences? This essay begins with describing the processes of transcending and ethitization, which gave rise to the biblical notion of sin. It portrays the theological foundation of sin in terms of a twofold refusal of proper relations to God and other humans. Through the practise of confession in the face of God (coram deo), sin is placed into a horizon of hope for forgiveness and reconciliatio…
Effects of GABA-transporter (GAT) inhibitors on rat behaviour in open-field and elevated plus-maze.
1999
The behavioural consequences of inhibition of gamma-aminobutyric acid (GABA) uptake were studied. Two GABA uptake inhibitors, tiagabine and SKF 89976-A, were administered to rats, and behaviour was analysed 30 min later in a standard open field, an enriched open field, and an elevated plus-maze. Eight groups of animals received either saline (0.9%), tiagabine, or SKF 89976-A. At a dose of 18.5 mg/kg, tiagabine, an established antiseizure drug, impaired motor coordination, enhanced exploratory activity and reduced anxiety related behaviour. SKF 89976-A exhibited minimal effects over the dose range tested. These results indicate that inhibition of GABA uptake might be a pharmacological strate…
Lack of SCN1A Mutations in Familial Febrile Seizures
2002
Summary: Purpose: Mutations in the voltage-gated sodium channel subunit gene SCN1A have been associated with febrile seizures (FSs) in autosomal dominant generalized epilepsy with febrile seizures plus (GEFS+) families and severe myoclonic epilepsy of infancy. The present study assessed the role of SCN1A in familial typical FSs. Methods: FS families were selected throughout a collaborative study of the Italian League Against Epilepsy. For each index case, the entire coding region of SCN1A was screened by denaturant high-performance liquid chromatography. DNA fragments showing variant chromatograms were subsequently sequenced. Results: Thirty-two FS families accounting for 91 affected indiv…
Zvaigžņotā Debess: 2011, Pavasaris (211)
2011
Contents: “ZVAIGŽŅOTĀ DEBESS” FORTY YEARS AGO: A.Alksnis. XIV General Assembly of the International Astronomical Union (abridged) ; H.Strods. Jaunlaicene’s Watchmaker (abridged) ; I.Daube. At the Radioastrophysical Observatory of the Latvian Academy of Sciences (abridged). 50 YEARS SINCE GAGARIN’S SPACE FLIGHT: R.Misa. Dream about Cosmos ; A.Zalcmane. Konstantin Tsiolkovsky Astronautics Museum in Kaluga; E.Bērziņa. Outer Space in Pauls Stradins Museum of History of Medicine. NEWS: A.Alksnis. Different Faces of Whirpool Galaxy ; A.Alksnis. The Kleopatra’s Trio and other Minor Planets Groups. SPACE RESEARCH and EXPLORATION: V.Kalniņš. NASA Preparing Solar Probe Plus to Plunge into Sun's Atmos…
¡No son las criaturas, es la Academia! Brechas salariales de género y carrera investigadora en la Universidad
2021
El objetivo del presente texto es presentar a la maternidad como argumento que naturaliza las dificultades de las mujeres en sus carreras académicas y que desplaza a los actuales criterios de evaluación científica. A partir de un estudio sobre la brecha salarial en la Universitat de València se identifican y se confrontan situaciones salariales como la penalización por maternidad y el plus salarial por paternidad para tratar de reconocer cómo opera una institución meritocrática. Se analiza el complemento salarial por sexenios que reconoce salarialmente la productividad de hombres y mujeres que ocupan posiciones estables en launiversidad y sus repercusiones en las distintas áreas de conocimi…
Weak warning signals can persist in the absence of gene flow.
2019
Significance With our comprehensive set of field (model survival), laboratory (controlled learning, palatability, toxin analysis), and molecular data, we provide evidence that polymorphism can persist in an aposematic population, despite expectations of positive frequency-dependent selection. We show that this can happen if prey species carrying a strong signal can exploit predator learning to elicit broad avoidance of many signals, even if predators only have experience with a single signal. This could allow novel signals to be protected within a population of aposematic prey. Thus, under the expectations of broad generalization coupled with limited gene flow, weak aposematic signals can p…
The Role of Assumptions in Ohlson Model Performance: Lessons for Improving Equity-Value Modeling
2021
In this paper, we test whether the short-run econometric conditions for the basic assumptions of the Ohlson valuation model hold, and then we relate these results with the fulfillment of the short-run econometric conditions for this model to be effective. Better future modeling motivated us to analyze to what extent the assumptions involved in this seminal model are not good enough approximations to solve the firm valuation problem, causing poor model performance. The model is based on the well-known dividend discount model and the residual income valuation model, and it adds a linear information model, which is a time series model by nature. Therefore, we adopt the time series approach. In…
Validation of Doloplus-2 among nonverbal nursing home patients : an evaluation of Doloplus-2 in a clinical setting
2010
Published version of an article from the journal: BMC Geriatrics. Also available from the publisher: http://dx.doi.org/10.1186/1471-2318-10-9 BACKGROUND:Pain measurement in nonverbal older adults is best based on behavioural observation, e.g. using an observational measurement tool such as Doloplus-2. The purposes of this study were to examine the use of Doloplus-2 in a nonverbal nursing home population, and to evaluate its reliability and validity by comparing registered nurses' estimation of pain with Doloplus-2 scores.METHOD:In this cross-sectional study, Doloplus-2 was used to observe the pain behaviour of patients aged above 65 years who were unable to self-report their pain. Nurses al…
CERME7 Working Group 15: Technologies and resources in mathematics education
2012
International audience
Efectos conductuales y neuroquímicos del consumo de éxtasis y cocaína en ratones adolescentes.
2009
La 3,4-metilendioximetanfetamina (MDMA), una sustancia popularmente conocida como éxtasis, es una droga ilícita consumida habitualmente por adolescentes y adultos jóvenes. Además, el policonsumo es una práctica habitual entre los usuarios de la MDMA, siendo la cocaína una de las drogas más frecuentemente asociadas a esta sustancia. El objetivo del presente trabajo fue evaluar los efectos a corto y largo plazo que se producen tras la administración de la MDMA (5, 10, o 20 mg/kg) sola o en combinación con cocaína (25 mg/kg) en ratones adolescentes. En el estudio sobre el efecto agudo, observamos que ambas drogas administradas individual o simultáneamente incrementan la actividad motora. La do…