Search results for "POA"

Are smartphone applications (App) useful to improve hearing?

2020

Le App per smartphone possono essere utili per migliorare l’udito?L’obiettivo dello studio è quello valutare l’efficacia di un’App per smartphone creata con lo scopo di migliorare le performance uditive sia in soggetti normoudenti che in pazienti affetti da ipoacusia da lieve a severa. Si tratta di uno studio analitico multicentrico, eseguito tra giugno e dicembre 2017, che ha analizzato un campione di 68 pazienti di cui 55 ipoacusici e 13 normoudenti; a tutti i pazienti sono stati somministrati test audiologici specifici sia durante l’utilizzo della suddetta App che in assenza di ausili uditivi. Il protocollo di valutazione audiologica prevedeva l’esecuzione di un’audiometria tonale limina…

File of Habilitation to Supervise Research

2023

Inhibition of human allergic T-helper type 2 immune responses by induced regulatory T cells requires the combination of interleukin-10-treated dendri…

2006

Summary Background In grass pollen-allergic individuals, T cell anergy can be induced by IL-10-treated dendritic cells (IL-10-DC) resulting in the suppression of T helper type 1 (Th1) as well as Th2 cells. This study was performed to analyse whether such IL-10-DC-treated T cells are able to act as regulatory T cells (Treg) suppressing the function of other T cells in the periphery. As transforming growth factor (TGF)-β is also a potential inducer of Treg, we additionally analysed the inhibitory capacity of TGF-β-treated T cells in this system. Materials and Methods Freshly isolated CD4+ or CD4+CD25− T cells from grass pollen-allergic donors were stimulated with autologous mature monocyte-de…

Frequenza e fenotipo delle mutazioni GJB2 in pazienti con ipoacusia neurosensoriale non-sindromica congenita: analisi di una coorte della Sicilia Occ…

Circa il 60% delle ipoacusie congenite sono associate a cause genetiche nei paesi sviluppati. La sordità genetica è classificata in sindromica (30%) e non sindromica (70%), quest’ultima riconducibile in più del 50% dei casi a mutazioni del gene GJB2. Tale gene, espresso nella coclea, codifica per la proteina gap junction “Connessina 26”, la cui funzione è cruciale per la comunicazione intercellulare. L’obiettivo del nostro lavoro è stato quello di stimare la frequenza delle mutazioni GJB2 e la loro correlazione con il fenotipo audiologico in 102 pazienti siciliani affetti da sordità neurosensoriale congenita non sindromica (NSHL) bilaterale e portatori di almeno una mutazione del gene GJB2.…

Epidemiologia, aspetti genetici e clinici nei neonati con familiarità per ipoacusia: esperienza di un centro di terzo livello

2012

INTRODUZIONE Rilievo frequente nei soggetti affetti da ipoacusia neurosensoriale (SNHL) è un' anamnesi familiare positiva per sordità, correlata a mutazioni genetiche, non sempre facilmente individuate, responsabili del deficit uditivo. L'eziologia genetica costituisce complessivamente il 50-60% di tutte le cause di sordità. Si distinguono forme sindromiche e non sindromiche, queste ultime classificabili secondo le differenti modalità di trasmissione. Nel 50-80% dei casi è riscontrabile una mutazione interessante il gene della connessina 26 (GJB2) localizzato sul cromosoma 13 che oramai è noto, codifica per una proteina chiamata in causa nei processi di trasduzione dello stimolo sonoro. La …

Stipa zeravshanicasp. nov. (Poaceae), an endemic species from rocky walls of the western Pamir Alai Mountains (middle Asia)

2013

Stipa zeravshanica M. Nobis sp. nov. from the western Pamir Alai Mts (Tajikistan) is described and illustrated. Morphologically, the new species is similar to S. gracilis, but it is easily distinguishable by pilose (vs. glabrous) lower part of the awn, and generally somewhat longer ligules of the vegetative shoots. Epidermal patterns of the lemma in S. zeravshanica and three other closely related taxa, namely S. gracilis, S. himalaica and S. orientalis, were examined by means of SEM. The main macro-morphological and micro-morphological characteristics differentiating all mentioned species are presented. Additionally, a lectotype for S. gracilis is designated. Based on phytosociological rele…

Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsi…

2012

Abstract Background Advanced stages of leprosy show T cell unresponsiveness and lipids of mycobacterial origin are speculated to modulate immune responses in these patients. Present study elucidates the role of phenolicglycolipid (PGL-1) and Mannose-capped lipoarabinomannan (Man-LAM) on TCR- and TCR/CD28- mediated signalling. Results We observed that lipid antigens significantly inhibit proximal early signalling events like Zap-70 phosphorylation and calcium mobilization. Interestingly, these antigens preferentially curtailed TCR-triggered early downstream signalling events like p38 phosphorylation whereas potentiated that of Erk1/2. Further, at later stages inhibition of NFAT binding, IL-2…

The soggettuale groupanalytics research about the ‘mafiosa’ psychology

2009

This report proposes a review of the studies about the mafiosa psychology which was produced by the soggettuale groupanalytics research in the last 15 years. These studies have been developing trough three main directions: (a) The study upon dialogical relational processes between interior world - exterior world in the families of the mafia. (What does really characterize the conception in the world of mafia? Which psychic factors do characterize the belonging to the family of the mafia? How does the “self” originate and develop in relation to the family and the polis? How do the familiar transpersonal level and the anthropological one weave in the members of mafia families?). (b) The study…

Fungal-Mediated Multitrophic Interactions : Do Grass Endophytes in Diet Protect Voles from Predators?

2009

Plant-associated micro-organisms such as mycotoxin-producing endophytes commonly have direct negative effects on herbivores. These effects may be carried over to natural enemies of the herbivores, but this has been rarely explored. We examined how feeding on Neotyphodium endophyte infected (E+) and endophyte free (E−) meadow ryegrass (Scherodonus pratensis) affects body mass, population size and mobility of sibling voles (Microtus levis), and whether the diet mediates the vulnerability of voles to least weasel (Mustela nivalis nivalis) predation. Because least weasels are known to be olfactory hunters, we also examined whether they are able to distinguish olfactory cues of voles fed on E+ a…

Safety and tolerability of seasonal ultra-rush, high-dose sublingual-swallow immunotherapy in allergic rhinitis to grass and tree pollens: an observa…

2009

We conducted a large observational study in 193 children and adolescents with allergic rhinitis due to grass or tree pollens to evaluate the safety and tolerability of an ultrarush high-dose sublingual immunotherapy (SLIT) regimen reaching a maintenance dose of 300 index of reactivity within 90 minutes.Children and adolescents aged 5 to 17 years with at least a 1-year medical history of allergic rhinitis with or without mild to moderate asthma due to tree pollens (birch, alder, hazel) or grass pollens (cocksfoot, meadow grass, rye grass, sweet vernal grass, timothy) were recruited. Standardized grass and tree pollen allergen extracts were used for ultrarush titration and subsequent coseason…