Search results for "POA"
showing 10 items of 245 documents
An alternative allergen:adjuvant formulation potentiates the immunogenicity and reduces allergenicity of a novel subcutaneous immunotherapy product f…
2012
Background Subcutaneous specific immunotherapy (SCIT) has proven sustained clinical efficacy against allergy. The recommended regimen for SCIT is a gradual updosing over a period of weeks. Commonly, in commercial products for SCIT, the specific allergen is formulated with an adjuvant, most often in the form of aluminium hydroxide (AlOH). It has been shown that allergen-specific IgG antibodies are induced as a result of successful SIT. Objective To investigate the possibility of optimizing the formulation of AlOH-based grass-pollen allergy vaccines for SCIT in a way that allows for shorter updosing regimens while maintaining the immunogenicity of the vaccine. Methods Mice were immunized with…
IgG, IgA, and IgE Antibodies to Cow Milk Proteins in an Allergy Prevention Study
1991
In the last few years, several trials have been carried out to determine if certain feeding regimens in neonates prevent atopic diseases1–13. In our country, there is a continuing debate about nutritional supplementation of breast milk with hydrolysate formulas: in the first days of life should only newborns at allergy risk8,9,11,14, or should all newborns be fed only breast milk? This age is claimed to be an especially vulnerable period for a sensitization against foreign proteins because of intestinal immaturity and inexperienced gut-associated lymphoid tissue15. A prospective Danish study revealed cases of cow’s milk allergy only among those breastfed infants who had received cow’s milk …
Changes in Terpene Content in Milk from Pasture-Fed Cows
2006
Changes of terpene content in milk from cows grazing natural diversified upland pasture were examined in this observational trial. A homogeneous plot divided into 2 subplots was used from May 31 to July 1, 2003 (first growth) and again from October 1 to October 7, 2003 (vegetative regrowth). Each subplot was grazed by 6 dairy cows in 2 ways: strip grazing (SG), with new allocations of pasture strips at 2-d intervals, and paddock grazing (PG). The PG subplot was divided into 3 paddocks and the cows were moved to a new paddock on June 13 and June 24, 2003. Milk from the 6 cows was collected twice a week, pooled, and used for terpene analyses by dynamic headspace gas chromatography-mass spectr…
L’obesità viscerale ed un aumentato rapporto ApoB/ApoA1 fanno perdere la protezione cardiovascolare di genere nelle donne diabetiche tipo 2.
2012
Gene-diet interaction in plasma lipid response to plant sterols and stanols: A review of clinical trials
2021
Abstract Plant sterols and stanols (PS) are well known for their cholesterol-lowering effect by reducing intestinal absorption of cholesterol. However, genetic factors modulate the low-density lipoprotein cholesterol (LDL-C) response to PS therapy. This review examines clinical trials evaluating the impact of the main genes associated with response of plasma lipid concentrations to PS intake: APOE, CYP7A1, ABCG5/G8, NPC1L1, CETP, APOA4/A5, SCARBI, HMGCR, PPARα, LIPC, MTHFR and LPA. Evidence indicates that carriers of mutant allele of the CYP7A1 c. −204 A > C variant experience a greater plasma cholesterol reduction after PS intake, although there is discrepancy for the rest of genetic varia…
Studies on the impact of winter climate on rubber and wheat cultivation in the mountains of southern China, applying a fuzzy cluster analysis
1992
Data from climatic stations in China, located south of 30° N and > 400 m above sea-level, were analysed in order to study the relationship with winter climate, on the one hand, and with rubber and winter wheat cultivation, on the other. Three relevant agroclimatic parameters were investigated for January, namely mean temperature, precipitation total and sunshine duration. By applying a fuzzy cluster analysis, three agroclimatic regions were found in winter; the boundaries coincide with the macro-scale topography of southern China. In one case the boundary even corresponds with the position of the Kunming quasi-stationary front. Winter climate in the three agroclimatic regions was found to s…
Typification of Dactylis ibizensis (Poaceae) and inference of the ploidy level of the type specimen
2021
A global database of C 4 photosynthesis in grasses
2014
Upregulation of liver VLDL receptor and FAT/CD36 expressions in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid
2006
International audience; This study explores the mechanisms responsible for the fatty liver setup in mice fed trans-10,cis-12 conjugated linoleic acid (t10c12 CLA), hypothesizing that an induction of low density lipoprotein receptor (LDLR) expression is associated with lipid accumulation. To this end, the effects of t10c12 CLA treatment on lipid parameters, serum lipoproteins, and expression of liver lipid receptors were measured in LDLR(-/-) apoB(100/100) mice as a model of human familial hypercholesterolemia itself depleted of LDLR. Mice were fed t10c12 CLA over 2 or 4 weeks. We first observed that the treatment induced liver steatosis, even in the absence of LDLR. Mice treated for 2 weeks…
Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor.
2005
Regulatory CD4+ CD25+ FoxP3-positive T cells (Treg) are functional in most atopic patients with allergic rhinitis and are able to inhibit T helper type 1 (Th1) and Th2 cytokine production of CD4+ CD25- T cells. This study was designed to analyse the following additional aspects: influence of allergen concentration, influence of the type of allergen, and influence of the atopy status of the donor on the strength of the regulatory activity. CD4+ CD25- T cells from healthy non-atopic controls or from grass-pollen-allergic or wasp-venom-allergic donors were stimulated alone or in the presence of Treg with autologous mature monocyte-derived dendritic cells which were pulsed with different concen…