Search results for "PPAR"

Il pagamento al creditore apparente nella prospettiva di un diritto europeo dell'obbligazione

2009

Il saggio analizza l’istituto del pagamento al creditore apparente e ne offre una rilettura in chiave di modi di estinzione dell’obbligazione diverso dell’inadempimento fondato sulla rottura del nesso di correlazione tra debito e credito. Lo studio del pagamento al creditore apparente offre, inoltre, una decisiva conferma della nozione di obbligazione come rapporto giuridico al cui interno trovano la sintesi due situazioni giuridiche dal contenuto diverso: il debito e il credito. La diversità di contenuto di debito e credito rappresenta la più significativa caratteristica dell’obbligazione e fa segnare la distanza dalla nozione tradizionale di obbligazione connotata invece dalla specularità…

MOTILITA' DELL'APPARATO DIGERENTE.

2018

Epidemiology, Physiology and Clinical Approach to Sleepiness at the Wheel in OSA Patients: A Narrative Review

2022

Sleepiness at the wheel (SW) is recognized as an important factor contributing to road traffic accidents, since up to 30 percent of fatal accidents have been attributed to SW. Sleepiness-related motor vehicle accidents may occur both from falling asleep while driving and from behavior impairment attributable to sleepiness. SW can be caused by various sleep disorders but also by behavioral factors such as sleep deprivation, shift work and non-restorative sleep, as well as chronic disease or the treatment with drugs that negatively affect the level of vigilance. An association between obstructive sleep apnea (OSA) and motor vehicle accidents has been found, with an increasing risk in OSA pati…

A dynamic multiple receptor conformations (MD-MRC) approach to enhance early enrichment in virtual screening. A case study on PPAR-alpha

2016

Ciò che dicono (e non dicono) le Sezioni Unite sul rapporto tra stalking, omicidio aggravato e lesioni aggravate

2022

Le Sezioni Unite hanno chiarito che il reato di omicidio commesso nei confronti della stessa persona offesa del reato di atti persecutori integra un reato complesso. Il presente contributo esamina le conseguenze che questo principio ha sul tema parallelo del rapporto tra il delitto di atti persecutori e il delitto di lesioni personali aggravate perché commesso dall'autore dello stalking nei confronti della stessa vittima. The United Sections have clarified that the crime of homicide committed against the same offended person as the crime of persecutory acts integrates a complex crime. This article examines the consequences that this principle has on the parallel theme of the relationship be…

Conseguenze metaboliche dell'ipossia

2011

Riassunto La sopravvivenza in condizioni di ipossia dipende dall’attivazione di processi cellulari complessi, con risposte di adattamento (quali il potenziamento del trasporto di O2 attraverso l’aumento dell’eritropoiesi, l’attivazione dell’angiogenesi e l’aumento della glicolisi anaerobica) e l’inibizione di processi metabolici che richiedono alta disponibilità di O2. Ciò consente di mantenere l’omeostasi energetica anche in condizioni di ridotta disponibilità di O2. Nel modello fisiologico del soggiorno ad alta quota si verificano riduzione di peso e della capacità di lavoro associata a riduzione della massa muscolare, che però sono reversibili al ripristino di condizioni di normossia. Le…

Anatomy of the cervical spine

2015

The vertebral column, or spine, consisting of a coordinated series of 33-34 vertebrae separated from each other by intervertebral disks, is divided in five segments or sections: cervical, dorsal, lumbar, sacral and coccygeal [1-7]. Not available

Le Fratture di Rotula

2015

Patellar fractures are relatively uncommon, accounting for approximately 1% of all fractures. Non-operative treatment represents the best choice for undisplaced patellar fractures. However, surgery becomes necessary when fractures are displaced by more than 2 mm, and may include open reduction and internal fixation. Accurate reduction and rigid fixation are required in order to allow early knee mobilization and to obtain a better clinical outcome. Several techniques have been described for patellar fracture fixation, such as tension band wiring, interfragmentary screw fixation, and the combination of screw fixation and cerclage. In this article up-to-date diagnosis, classification and treat…

Safety of intra-articular hip injection of hyaluronic acid products by ultrasound guidance: an open study from ANTIAGE register.

2013

Abstract. – OBJECTIVE: We developed a standardized technique for ultrasound guided intra-articular injection of the hip joint with the purpose of extending routine intra-articular injection of hyaluronans and steroids to the hip, as commonly used in the knee. In this article we report the safety of this technique in an extended series of patients. PATIENTS AND METHODS: Patients were injected supine with an anterosuperior approach under ultrasound guidance. The Us probe is applied with a target device for biopsy. RESULTS: The standardised technique was used to inject 1906 patients with 4002 injections of hyaluronan products over a four-year period. The treatment was well tolerated with few, …

Duchenne Muscular Dystrophy (DMD): Should it be Considered a Systemic Disease?

2016

Duchenne muscular dystrophy (DMD) is an X-linked muscle disease characterized by progressive skeletal muscle loss and development of respiratory failure due to involvement of respiratory muscles. Similar to human DMD, the mdx mouse model lacks dystrophin but is characterized by relatively mild muscle injury, allowing testing the effects of mild endurance exercise training on dystrophic skeletal muscle. We were interested to study the effects of exercise training on airway cells in trained mdx mice by applying the same protocol previously tested in Swiss mice. We found that mdx mice showed little airway inflammation associated with training, but developed increasing apoptosis of airway cells…