Search results for "PPD"

Toppdommerrollen i fotball : sammenhengen mellom angst og mental tøffhet og toppdommeres subjektive opplevelse av press i norsk fotball

2016

Masteroppgave i idrettsvitenskap - Universitetet i Agder 2016 Mental toughness, anxiety and pressure are well-used terms within sports, even though it can be difficult to understand the meaning of them. The purpose of this study was to examine the relationship between anxiety (cognitive- and somatic anxiety and self-confidence) and mental toughness, and top-class referees’ subjective experience on pressure as a soccer official. 183 top-class referees answered an online questionnaire. Mental toughness was measured by using the SMTQ and anxiety by using the CSAI-2. Of all the referees included in this study, 97.2% had been active footballers themselves, 44.3% had played on a high level. There…

Modulació de l'artritis gotosa per dues molècules inhibidores de la caspasa-1

2020

L’artritis gotosa es una de les malalties articulars més freqüents d’artritis inflamatòria. Es produeix per la deposició d’urat monosòdic (MSU) en les articulacions, donant lloc a episodis aguts d’inflamació, que poden ser persistents i arribar a cronificar-se. La fagocitosi dels cristalls d’MSU pels neutròfils i macròfags genera la producció de ROS i l’activació de l’NFkappaB, alliberant citocines i activant l’NLRP3. Aquest inflamasoma indueix l’activació de la caspasa1 i la consegüent producció de les formes actives IL1beta i IL18. Les calcones són un grup de la família dels flavonoides, que han demostrat propietats antiinflamatòries i antiartrítiques, actuant sobre diverses dianes terapè…

Docking and synthesis of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors: New scaffolds for DNA-interacting agents

2007

New classes of pyrrolopyrimidodiazepinone derivatives (PPDs) and their precursors were studied in silico for their ability to form stable complex with DNA fragment. In the docking studies two binding modes can be envisaged: groove mode and intercalating mode. In the case of the best ligands the docking studies revealed a common binding mode with the chromophore intercalated between GC base pairs whereas the side chain lies close to the minor groove. Synthetic approach to the PPD ring systems is discussed.

Experimental Research of Thermal Comfort Conditions in Small Test Buildings with Different Types of Heating

2015

Abstract The aim of this study is detailed analysis of long-term monitoring data of thermal comfort conditions and energy efficiency in small test buildings equipped with different heating systems. Calculations of PPD index and local thermal discomfort factors are provided for the test buildings during three weeks of heating season. It is shown that the type of heating system has influence not only on heating energy need, but also on thermal comfort conditions in the room.

DIAGSOL : development of a new functional marker of exposure to herbicides B-triketones in an agricultural soil

2020

Numerous herbicides target an enzyme found not only in weeds but also in « non-target organisms » such as microorganisms. This proof-of-concept study aims to use microbial gene encoding the targeted enzyme or the targeted enzyme itself as a marker for herbicide exposure in soils. The hppd gene and the encoded enzyme (HPPD; 4-hydroxyphenylpyruvate dioxygenase), targeted by B-triketone herbicides, are the subject of this study. In silico analyses reveal that the hppd gene is spread out in all bacterial phyla. Primers specific to this gene were designed. This primer pair is used to measure the abundance, the composition and the diversity of the hppd bacterial community in soil microcosms expos…

A new tool to assess the ecotoxicological impact of β-triketone herbicides on soil microbial communities

2018

International audience; The β-triketone herbicides are post-emergence maize selective herbicides that have beenintroduced on the market, in replacement of atrazine, banned in Europe in 2004. Qualified as “eco-friendly”, since they are based on natural phytotoxin properties, these herbicides target an enzymeinvolved in carotenoid biosynthesis called 4-hydroxyphenylpyruvate dioxygenase (HPPD) encoded bythe hppd gene. The inhibition of this enzyme provokes bleaching symptoms, necrosis and death ofweeds.The hppd gene is not only find in eukaryotes such as plants, animals and humans but also inprokaryotes such as fungi, yeasts and bacteria. In recent studies, we showed that, within the soil bact…

Utilisation de la technique du FRAP pour évaluer la fluidité de la membrane plasmique de cellules végétales en suspension

2014

Effects of cyber domain in crisis management

2019

There is fundamental need in EU-level to develop common alarm procedures and emergency response models with preventive functions which work well from local to national level and from national to international level. European Public Protection and Disaster Relief (PPDR) services such as law enforcement, firefighting, emergency medical and disaster recovery services have recognized that lack of interoperability of technical systems limits cooperation between the PPDR authorities. Also, the military (MIL) and critical infrastructure protection (CIP) faces similar challenges. Recent major accidents have indicated that lack of human resources affects to disaster recovery. PPDR-actors cannot star…

The Burden of Respiratory Syncytial Virus Disease in Pre-Term Infants

2015

This mini-review summarises the risk factors for acquiring Respiratory Syncitial Virus (RSV) infection, and describes the harmful effects of the infection in pre-term infants. Moreover, theoretical considerations are discussed for the prevention of RSV infection in high-risk infant categories, such as pre-term infants. Background: Neonates positive for RSV are more prone to severe infection than neonates infected with other common respiratory viruses. Despite RSV infection being more common in late neonates than in early ones, pre-term infants ≤ 35 wk gestational age (GA) are at high risk for developing severe RSV disease. Efforts to prevent infection include case management, vaccination an…

DIAGSOL : Développement d’un outil microbien pour évaluer l’exposition des sols agricoles aux herbicides β-tricétones

2018

International audience; En 2011, en France, plus de 2 millions d’hectares de champs de maïs ont été traités avec desherbicides β-tricétones. Qualifiés de « respectueux de l’environnement » en raison d’une efficacité àfaible dose, de récentes études ont démontré un effet transitoire des β-tricétones sur la diversitébactérienne des sols (Romdhane et al., 2016). L’utilisation récurrente des β-tricétones pourrait, àterme, perturber la diversité bactérienne et les fonctions écosystémiques des sols qu’elle soutient.Il est essentiel d’évaluer l’exposition des microorganismes des sols aux β-tricétones.L’enzyme 4-hydroxyphénylpyruvate dioxygénase (4-HPPD), cible de ces herbicides chez les plantesadv…