Search results for "PRECISION"
showing 10 items of 448 documents
Automatic analyzis of droplet impact by high speed imaging
2012
International audience; The impact of agricultural activities on the water quality is the consequence of the loss of fertilisers (chemical fertilisers, livestock effluent, also referred to as farm fertiliser, food-processing effluent and sludge) and crop treatment products (phytosanitary products). This pollution may prevent certain uses of water, notably its use for human and animal food (groundwater and surface water), and leads to a deterioration in aquatic environments. In the domain of vineyard precision spraying research, one of the most important objectives is to minimize the volume of phytosanitary products. It is also to be more environmentally respectful with more effective vine l…
HYPERSPECTRAL REFLECTANCE SIGNATURES AND POINT CLOUDS FOR PRECISION AGRICULTURE BY LIGHT WEIGHT UAV IMAGING SYSTEM
2018
Abstract. The objective of this investigation was to study the use of a new type of a low-weight unmanned aerial vehicle (UAV) imaging system in the precision agriculture. The system consists of a novel Fabry-Perot interferometer based hyperspectral camera and a high-resolution small-format consumer camera. The sensors provide stereoscopic imagery in a 2D frame-format and they both weigh less than 500 g. A processing chain was developed for the production of high density point clouds and hyperspectral reflectance image mosaics (reflectance signatures), which are used as inputs in the agricultural application. We demonstrate the use of this new technology in the biomass estimation process, w…
Autonomous hyperspectral UAS photogrammetry for environmental monitoring applications
2014
Abstract. The unmanned airborne system (UAS) remote sensing using lightweight multi- and hyperspectral imaging sensors offer new possibilities for the environmental monitoring applications. Based on the accurate measurements of the way in which the object reflect and emit energy, wide range of affecting variables can be monitored. Condition for reliable applications is reliable and accurate input data. In many applications, installation of geometric and radiometric reference targets in the object area is challenging, for instance, in forest or water areas. On the other hand, UASs are often operated in very poor conditions, under clouds or under variable cloud cover. Our objective is to deve…
Mechanistic Modeling and Multiscale Applications for Precision Medicine: Theory and Practice
2020
Drug research, therapy development, and other areas of pharmacology and medicine can benefit from simula- tions and optimization of mathematical models that contain a mathematical description of interactions between systems elements at the cellular, tissue, organ, body, and population level. This approach is the foundation of systems medicine and precision medicine. Here, simulated experiments are performed with computers (in silico) first, and they are then replicated through lab experiments (in vivo or in vitro) or clinical studies. In turn, these experiments and studies can be used to validate or improve the models. This iterative loop of dry and wet lab work is successful when biomedica…
New Sub-Phenotyping of Subjects at High Risk of Type 2 Diabetes: What Are the Potential Clinical Implications?
2021
Prediabetes is defined as a condition of abnormal glucose metabolism, characterised by plasma glucose above normal range but not as high as required for the diagnosis of diabetes mellitus (DM). It represents a heterogeneous entity of intermediate glucose metabolism, including impaired fasting glucose, impaired glucose tolerance, and borderline glycated haemoglobin. Prediabetes is being increasingly recognised as an important metabolic state not only predisposing to a higher probability of future progression to DM, but also to an increased risk of different micro- and macrovascular complications. The recently proposed sub-phenotyping of individuals at increased risk of type 2 DM, which disti…
Radiomics and radiogenomics in head and neck squamous cell carcinoma: Potential contribution to patient management and challenges
2021
Abstract The application of imaging biomarkers in oncology is still in its infancy, but with the expansion of radiomics and radiogenomics a revolution is expected in this field. This may be of special interest in head and neck cancer, since it can promote precision medicine and personalization of treatment by overcoming several intrinsic obstacles in this pathology. Our goal is to provide the medical oncologist with the basis to approach these disciplines and appreciate their main uses in clinical research and clinical practice in the medium term. Aligned with this objective we analyzed the most relevant studies in the field, also highlighting novel opportunities and current challenges.
A Decision Support Tool for Appropriate Glucose-Lowering Therapy in Patients with Type 2 Diabetes
2015
Contains fulltext : 152084.pdf (Publisher’s version ) (Open Access) BACKGROUND: Optimal glucose-lowering therapy in type 2 diabetes mellitus requires a patient-specific approach. Although a good framework, current guidelines are insufficiently detailed to address the different phenotypes and individual needs of patients seen in daily practice. We developed a patient-specific decision support tool based on a systematic analysis of expert opinion. MATERIALS AND METHODS: Based on the American Diabetes Association (ADA)/European Association for the Study of Diabetes (EASD) 2012 position statement, a panel of 12 European experts rated the appropriateness (RAND/UCLA Appropriateness Method) of tre…
Effectiveness of benralizumab in severe eosinophilic asthma: Distinct sub-phenotypes of response identified by cluster analysis
2022
Background: Benralizumab is effective in severe eosinophilic asthma (SEA), but suboptimal responses are observed in some patients. Although several factors have been associated with benralizumab response, no cluster analysis has yet been undertaken to identify different responsiveness sub-phenotypes. Objective: To identify SEA sub-phenotypes with differential responsiveness to benralizumab. Methods: One hundred and five patients diagnosed with SEA who had completed 6 months of benralizumab treatment were included in a hierarchical cluster analysis based on a set of clinical variables that can be easily collected in routine practice (age, age at disease onset, disease length, allergen sensit…
Utilizing nutritional genomics to tailor diets for the prevention of cardiovascular disease: a guide for upcoming studies and implementations.
2017
Introduction: Personalized diets based on an individual’s genome to optimize the success of dietary intervention and reduce genetic cardiovascular disease (CVD) risk, is one of the challenges most frequently discussed in the scientific community. Areas covered: The authors gathered literature-based evidence on nutritional genomics and CVD phenotypes, our own results and research experience to provide a critical overview of the current situation of using nutritional genomics to tailor diets for CVD prevention and to propose guidelines for future studies and implementations. Expert commentary: Hundreds of studies on gene-diet interactions determining CVD intermediate (plasma lipids, hypertens…
Pharmacogenomics in psychiatry: from therapeutic drug monitoring to genomic medicine.
2013
Psychiatry is increasingly combining new pharmacogenomic findings with therapeutic drug monitoring (TDM) to improve the safety and efficacy of pharmacotherapy. However, a distinction should be made between “nice to know” and “need to know” pharmacogenomic data because many results are statistically significant in meta-analyses but are not clinically relevant due to their low effect sizes. Some examples will illustrate this integration.