Search results for "PREM"

Transcranial Magnetic Stimulation and Neuroimaging Coregistration

2013

The development of neuroimaging techniques is one of the most impressive advancements in neuroscience. The main reason for the widespread use of these instruments lies in their capacity to provide an accurate description of neural activity during a cognitive process or during rest. This important advancement is related to the possibility to selectively detect changes of neuronal activity in space and time by means of different biological markers. Specifically, functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and nearinfrared spectroscopy (NIRS) use metabolic markers of ongoing neuronal activity to provide a…

Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs

In Cystic fibrosis (CF) disease nonsense mutations in the CFTR gene cause the absence of the CFTR protein expression and a more severe form of the disease. About 10% of patient affected by CF show a nonsense mutation. A potential treatment of this alteration is to promote translational readthrough of premature termination codons (PTCs) by translational readthrough inducing drugs such as Ataluren (1). We reported a rationale for Ataluren promoted readthrough of PTCs by computational approach and GFP-reporter cell-based assay (2) and the observed enhancement of readthrough activity by some Ataluren derivatives (3, 4). In this context we aimed to compare the 1,2,4-oxadiazole core of Ataluren w…

Anomalías craneofaciales y dentales en una población de escolares nacidos pretérmino

2022

En las últimas décadas hemos podido asistir a un incremento en el número de partos pretérmino como consecuencia de diversos factores tecnológicos y sociales tales como la incorporación de la mujer al mercado laboral, el aumento de la edad media de las gestantes, el desarrollo de las técnicas de reproducción asistida y otros factores locales como la migración que repercute negativamente en las condiciones socioeconómicas y sanitarias de las gestantes. De la misma manera, los importantes avances logrados en las unidades neonatales han permitido la supervivencia de recién nacidos (RN) de edades gestacionales (EG) cada vez más extremas. El uso de corticoides prenatales, la administración de sur…

Институт Омбудсмена в зарубежных странах в контексте применения опыта для Украины

2014

Disrupting neural activity related to awake-state sharp wave-ripple complexes prevents hippocampal learning

2012

Oscillations in hippocampal local-field potentials (LFPs) reflect the crucial involvement of the hippocampus in memory trace formation: theta (4–8 Hz) oscillations and ripples (~200 Hz) occurring during sharp waves are thought to mediate encoding and consolidation, respectively. During sharp wave-ripple complexes (SPW-Rs), hippocampal cell firing closely follows the pattern that took place during the initial experience, most likely reflecting replay of that event. Disrupting hippocampal ripples using electrical stimulation either during training in awake animals or during sleep after training retards spatial learning. Here, adult rabbits were trained in trace eyeblink conditioning, a hippoc…

OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF GENETIC DISEASES DUE TO NONSENSE MUTATIONS

2018

Are disclosed oxadiazole derivatives, their use as medicaments and in particular for the treatment of diseases associated with the presence of a nonsense mutation in the gene or a premature stop codon in the mRNA, pharmaceutical formulation comprising said oxadiazole derivatives and prodrug or mixture thereof and the methods for the preparation of said Oxadiazole derivatives.

Validez y eficacia de los pactos matrimoniales

2018

Los pactos matrimoniales es un tema de actualidad en nuestra sociedad. En este trabajo se ha pretendido abordar el tema de la validez y eficacia de los pactos matrimoniales y como encajan en nuestro ordenamiento jurídico. Por una parte tenemos que tener en cuenta la autonomía de la voluntad de las partes, pero se debe conjugar con el derecho de ius cogens y con los derechos inalienables tan presentes tradicionalmente en el derecho de familia. Es un tema además eminentemente práctico que trata de resolver evitar futuros conflictos y ahorrar tiempo y gastos a las partes, lo cual se conseguirá en el momento que se disponga de una regulación clara y precisa sobre la materia. Actualmente no hay …

Economics of wage premia and wage rigidity

2017

The focus of this dissertation is on the effects of specific employer characteristics on wages and wage rigidity and how these characteristics enter the wage-setting process. The dissertation includes an introductory chapter and five separate essays. The introduction provides motivation, background on the main keywords and an overview of the thesis. Chapters two and three study how internal references affect wages and wage rigidity from a theoretical perspective. The fourth chapter estimates the effect of firm size on wages in the Finnish labor market. Chapter five develops on the preceding and analyses how profit sharing schemes affect the firm size premium. Chapter six studies how interna…

Salud respiratoria en prematuros tardíos, 32-35 semanas de edad gestacional. Seguimiento en edad preescolar y escolar.

2015

Como se describe en múltiples trabajos, la prevalencia de enfermedades respiratorias inmediatas y tardías en los nacidos prematuramente, es mayor que en los nacidos a término (RNAT). En las últimas décadas, dada la cada vez más numerosa tasa de nacimientos prematuros, se ha observado un incremento de este tipo de estudios, centrándose fundamentalmente en los grandes pretérmino o en los recién nacidos (RN) que presentan algún tipo de enfermedad pulmonar desde los primeros días de vida. En cambio, se ha prestado menos atención a los niños mayores de 32 semanas de edad gestacional (EG), sin ningún problema respiratorio de base. En los prematuros moderados y tardíos, las líneas de estudio se ce…

Dire institutionnel et espaces de langage - le cas de l'Algérie - Essai d'une sémio-didactique

1992

This thesis is 1) an discourse analysis of the institution' texts (Algeria, in the eighties) + analysis of the young people in secondary school (part I) ; 2) a semiotic analysis of spaces in Algeria (country, village, secondary school). The results : we showed many contraints in a collective speech, through 2 dominant themas : time, action ; and 2 recessive themas : subject (speaker), mirror. So, education and didactic perspective are useful.