Search results for "PRODUCTS"
showing 10 items of 980 documents
Bioactive polyketides and alkaloids from Penicillium citrinum , a fungal endophyte isolated from Ocimum tenuiflorum
2013
Chemical investigation of the endophytic fungus Penicillium citrinum cultured on white beans or on rice led to the isolation of two new alkaloids (1 and 2), along with fourteen known polyketides (6-12, 14-20) and four known alkaloids (3-5, and 13). The structures of the isolated compounds were determined by extensive analysis of the 1D, 2D NMR, and MS data, and by comparison with the literature. Compound 13, which had been previously obtained only by chemical synthesis, was isolated as a natural product for the first time, while compound 6 was firstly reported as a fungal metabolite. A re-isolation of sclerotinin A (14) revealed it to be a diastereoisomeric mixture (14a and 14b), whose ster…
Genericity of dimension drop on self-affine sets
2017
We prove that generically, for a self-affine set in $\mathbb{R}^d$, removing one of the affine maps which defines the set results in a strict reduction of the Hausdorff dimension. This gives a partial positive answer to a folklore open question.
Acylated oleanane-type saponins from Ganophyllum giganteum
2014
Abstract Five oleanane-type saponins , 3- O -β- D -glucuronopyranosylzanhic acid 28- O -β- D -xylopyranosyl-(1→3)-[α- L -rhamnopyranosyl-(1→2)]-(4- O -acetyl)-β- D -fucopyranosyl ester ( 1 ), 3- O -β- D -glucopyranosylzanhic acid 28- O -β- D -xylopyranosyl-(1→3)-[α- L -rhamnopyranosyl-(1→2)]-(4- O -acetyl)-β- D -fucopyranosyl ester ( 2 ), zanhic acid 28- O -β- D -xylopyranosyl-(1→3)-[α- L -rhamnopyranosyl-(1→2)]-(4- O -acetyl)-β- D -fucopyranosyl ester ( 3 ), zanhic acid 28- O -α- L -rhamnopyranosyl-(1→2)-4- O -[(3′-hydroxy-2′-methyl-butyroyloxy)-3-hydroxy-2-methyl-butyroyloxy]-β- D -fucopyranosyl ester ( 4 ), medicagenic acid 28- O -α- L -rhamnopyranosyl-(1→2)-4- O -[(3′-hydroxy-2′-methyl-…
Beyond Pseudo‐natural Products: Sequential Ugi/Pictet‐Spengler Reactions Leading to Steroidal Pyrazinoisoquinolines That Trigger Caspase‐Independent …
2021
In this work, we describe how stereochemically complex polycyclic compounds can be generated by applying a synthetic sequence comprising an intramolecular Ugi reaction followed by a Pictet-Spengler cyclization on steroid-derived scaffolds. The resulting compounds, which combine a fragment derived from a natural product and a scaffold not found in nature. are both structurally distinct and globally similar to natural products at the same time, and interrogate an alternative region of the chemical space. One of the new compounds showed significant antiproliferative activity on HepG2 cells through a caspase-independent cell-death mechanism, an appealing feature when new antitumor compounds are…
Cytotoxic activity of some natural and syntetic sesquiterpene lactones
2006
Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.
Explaining the relationship between socially responsible products and the operations of the firm: The case of equine assisted therapy
2018
Abstract Although there is a growing interest in social responsibility in research as well as in practice, the majority of studies on corporate social responsibility do not explicitly investigate operations management issues when adopting socially responsible practices under the “people” pillar of sustainability. This paper, dealing with the theme of social responsibility in operations management, aims at clarifying the complex relationship between socially responsible product/service and the operations of the company. The empirical context of the study is the sport industry, where the attention to social issues is well established. We used a mixed theoretical-empirical approach to develop …
Use of gases to improve survival of Bifidobacterium bifidum by modifying redox potential in fermented milk
2011
The aim of this work was to study the effect of the oxidoreduction potential, modified using gas, on the growth and survival of a probiotic strain, Bifidobacterium bifidum, and 2 yogurt strains, Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus. Three fermented milks were manufactured with an initial oxidoreduction potential value adjusted to +440 mV (control milk), +350 mV (milk gassed with N(2)), and -300 mV [milk gassed with N(2) plus 4% (vol/vol) H(2) (N(2)-H(2))]. Acidification profiles, growth during milk fermentation and survival during storage at 4 °C for 28 d were determined. This study showed that fermented probiotic dairy products made from milk gassed with…
Is the Eco-label EU Decision for hard coverings really capable of capturing the environmental performances of the marble productive chain? A field ve…
2014
Purpose This work intends to show whether the Eco-label EU Decision for hard coverings, in which marble is contemplated among hard coverings as a natural product, is really capable of capturing the environmental performances of the marble productive chain, in other words whether it is actually viable for the natural products, like marble. Methods After a preliminary critical analysis of the suitability formarble of the current EU Decision (2009/607/EC), a classical life cycle assessment (LCA) methodology has been applied on the field to the marble “Perlato di Sicilia.” More specifically, the whole productive chain of a couple of firms treating the “Perlato di Sicilia” marble has been examin…
Trihalomethanes in swimming pool water in four areas of Spain participating in the INMA project
2010
ResumenObjetivoLa natación es uno de los deportes más practicados en España, por personas de todas las edades y condiciones físicas. También es una vía de exposición a subproductos de la desinfección, compuestos potencialmente tóxicos. Su concentración en el agua de las piscinas no está legislada y es poco conocida. El objetivo de este trabajo es describir la concentración de trihalometanos en el agua de piscinas de los municipios de cuatro cohortes del estudio INMA.MétodosEn julio de 2009 se analizaron los trihalometanos en el agua de piscinas (n=27) de Asturias, Granada, Valencia y Sabadell.ResultadosLa concentración media de trihalometanos totales fue de 42,7μg/l (desviación estándar [DE…
Acid- and Base-Catalysis in the Mononuclear Rearrangement of Some (Z)-arylhydrazones of 5-Amino-3-benzoyl-1,2,4-oxadiazole in Toluene: Effect of Subs…
2011
The reaction rates for the rearrangement of eleven (Z)-arylhydrazones of 5-amino-3-benzoyl-1,2,4-oxadiazole 3a-k into the relevant (2-aryl-5-phenyl-2H-1, 2,3-triazol-4-yl)ureas 4a-k in the presence of trichloroacetic acid or of piperidine have been determined in toluene at 313.1 K. The results have been related to the effect of the aryl substituent by using Hammett and/or Ingold-Yukawa-Tsuno correlations and have been compared with those previously collected in a protic polar solvent (dioxane/water) as well as with those on the analogous rearrangement of the corresponding (Z)-arylhydrazones of 3-benzoyl-5-phenyl-1,2,4-oxadiazole 1a-k in benzene. Some light can thus be shed on the general di…