Search results for "PROPOSAL"

Prognostic factors in stage III-IV adrenocortical carcinomas (ACC): an European Network for the Study of Adrenal Tumor (ENSAT) study

2015

Background: The clinical course of advanced adrenocortical carcinoma (ACC) is heterogeneous. Our study aimed primarily to refine and make headway in the prognostic stratification of advanced ACC.Patients and methods: Patients with advanced ENSAT ACC (stage III or stage IV) at diagnosis registered between 2000 and 2009 in the ENSAT database were enrolled. The primary end point was overall survival (OS). Parameters of potential prognostic relevance were selected. Univariate and multivariate analyses were carried out: model 1 'before surgery'; model 2 'post-surgery'.Results: Four hundred and forty-four patients with advanced ENSAT ACC (stage III: 210; stage IV: 234) were analyzed. After a medi…

Validation of the 2009 TNM Version in a Large Multi-Institutional Cohort of Patients Treated for Renal Cell Carcinoma: Are Further Improvements Neede…

2010

Background: A new edition of the TNM was recently released that includes modifications for the staging system of kidney cancers. Specifically, T2 cancers were subclassified into T2a and T2b ( 10 cm), tumors with renal vein involvement or perinephric fat involvement were classified as T3a cancers, and those with adrenal involvement were classified as T4 cancers. Objective: Our aim was to validate the recently released edition of the TNM staging system for primary tumor classification in kidney cancer. Design, setting, and participants: Our multicenter retrospective study consisted of 5339 patients treated in 16 academic Italian centers. Intervention: Patients underwent either radical or part…

¿Y dónde está la gracia? El humor en el aula de ELE

2017

Resumen : El presente trabajo muestra el fenomeno pragmatico del humor como un instrumento idoneo para suscitar la reflexion sobre el uso y funciones del lenguaje en los estudiantes de ELE.  Una vez expuestas las referencias al humor verbal y a la ironia por parte del Marco Comun Europeo de Referencia y el Plan Curricular del Instituto Cervantes , ofreceremos una propuesta didactica cuyo objetivo es la activacion y desarrollo de la competencia comunicativa. Muestras humoristicas como el monologo pueden contribuir a mejorar las destrezas linguisticas y pragmaticas en ELE desde niveles iniciales. Palabras clave: Humor, Competencia metapragmatica, ELE, Propuesta didactica. Abstract: This paper…

Research on Public Procurement of Information Systems: The Need for a Process Approach

2014

The Public Procurement of IS - A Process View

2014

This paper addresses a lack of research into public procurement of information systems, especially from a process focus. Three case studies from IS procurement in Norwegian municipalities are presented. By following one of the procurements in detail, the paper shows a process with a very strict phased division, an approach quite different from today's agile system development methods. The cases show the importance of the requirement specification which is completed before talking to vendors. They also show the need for clarifying the content of the offer, through a dialogue with the vendor. A number of critical incidents are identified, involving the interests of different stakeholders. Con…

Teaching of energy issues: A debate proposal for a global reorientatiom

2007

The growing awareness of serious difficulties in the learning of energy issues has produced a great deal of research, most of which is focused on specific conceptual aspects. In our opinion, the difficulties pointed out in the literature are interrelated and connected to other aspects (conceptual as well as procedural and axiological), which are not sufficiently taken into account in previous research. This paper aims to carry out a global analysis in order to avoid the more limited approaches that deal only with individual aspects. From this global analysis we have outlined 24 propositions that are put forward for debate to lay the foundations for a profound reorientation of the teaching o…

LEADING SECONDARY SCHOOL STUDENTS TO FACE THE DISCIPLINARY, EPISTEMOLOGICAL AND SOCIETAL CHALLENGES OF CLIMATE CHANGE: DESIGN AND ANALYSIS OF MULTI-D…

The scientific community has been debating climate change (CC) for over two decades. In the light of certain arguments put forward by the aforesaid community, the EU has recommended a set of innovative reforms to science teaching, such as incorporating environmental issues into the scientific curriculum, thereby helping to make schools a place of civic education. However, despite these European recommendations, relatively little emphasis is still given to climate change within science curricula. The main goal of the research project described in this thesis is to study if, how and why the scientific contents related to CC could be reconstructed so as to integrate the many dimensions involve…

Palermo si cura. Pratiche culturali di mutuo soccorso come risposta alle fragilità della città (post)pandemica

2023

In un quadro di riferimento in cui la crisi è globalizzata ma diseguale e in mancanza di un sistema di welfare capace di rispondere alle urgenze dei contesti e dei gruppi sociali più marginalizzati, una risposta ai nuovi bisogni sociali ed individuali è stata offerta da reti solidali e da pratiche di mobilitazione dal basso che svolgono un ruolo di agency territoriale, spesso indipendentemente o in assenza di Istituzioni. Nel contesto palermitano un impegno agito da una pluralità di soggetti culturali già attivi sul territorio, riuniti in un’assemblea pubblica (Palermo si cura), durante il periodo del primo lockdown hanno dato vita ad azioni di mutuo soccorso per rispondere all’emergenza ec…

La proposta di regolamento MiCA e la disciplina delle pratiche commerciali scorrette

2022

The most part of European and domestic supervisory authorities have underlined the likelihood that either the issuing and the negotiation of cryptoassets may be the final outcome of unfair and deceptive commercial practices. The discipline laid down by the Directive 2005/29/ CE – now expressely recalled by the MiCAR Proposal – seems to be crucial for the best functioning of the market at stake. The Author stresses how the interplay between «horizontal» and «vertical» measures needs the interpreters play a pivotal role, in order to grant the best understanding of the circumstances of the case as well as the best using of the «professional diligence» general clause.

Note brevi a margine della proposta di riforma dei reati ambientali del gruppo di studio dell'associazione dei professori di diritto penale

2022

A partire dall’analisi della proposta di riforma dei reati contro l’ambiente elaborata dal Gruppo di studio dell’Associazione italiana dei Professori di Diritto Penale, il contributo riflette sui principali problemi teorici del diritto penale ambientale (tipizzazione dell’evento lesivo nelle fattispecie di inquinamento e di disastro ambientale, imputazione soggettiva dei delitti aggravati dall’evento, contrasto penale alle c.d. “ecomafie” nel settore dei rifiuti ecc.), mettendo a confronto le soluzioni suggerite nel testo con le prospettive di riforma contenute nella recente Proposta di Direttiva del Parlamento europeo e del Consiglio sulla Protezione dell’ambiente at- traverso il diritto p…