Search results for "PSC"

Random attractors for stochastic lattice systems with non-Lipschitz nonlinearity

2011

In this article, we study the asymptotic behaviour of solutions of a first-order stochastic lattice dynamical system with an additive noise. We do not assume any Lipschitz condition on the nonlinear term, just a continuity assumption together with growth and dissipative conditions so that uniqueness of the Cauchy problem fails to be true. Using the theory of multi-valued random dynamical systems, we prove the existence of a random compact global attractor.

Non-Lipschitz Homogeneous Volterra Integral Equations

2018

In this chapter we introduce a class of nonlinear Volterra integral equations (VIEs) which have certain properties that deviate from the standard results in the field of integral equations. Such equations arise from various problems in shock wave propagation with nonlinear flux conditions. The basic equation we will consider is the nonlinear homogeneous Hammerstein–Volterra integral equation of convolution type $$\displaystyle u(t) = \int _0^t k(t-s) g(u(s))\,\mathrm {d}s. $$ When g(0) = 0, this equation has function u ≡ 0 as a solution (trivial solution). It is interesting to determine whether there exists a nontrivial solution or not. Classical results on integral equations are not to be …

Biopsy vs. brushing: comparison of two sampling methods for the detection of HPV-DNA in squamous cell carcinoma of the oral cavity

2012

Background: HR HPV infection was proposed as aetiological factor of oral squamous cell carcinomas (OSCC). HPV frequency in OSCC is highly variable, due to the discrepancy in oral sampling procedures, HPV testing methods and inclusion criteria regarding tumour site (strictly oral cavity vs. nearby structures). Our aim was to compare HPV DNA frequency and type-specific distribution in paired cytological and histological samples of SCC strictly located in oral cavity. The correlation between HPV detection rate by each method of sampling and demographical, behavioural and clinical-pathological variables was also examined. Patients and methods: HPV DNA was detected in brushed cells and formalin-…

Evaluation of a combined triple method to detect causative HPV in oral and oropharyngeal squamous cell carcinomas: p16 Immunohistochemistry, Consensu…

2012

Abstract Background Recent emerging evidences identify Human Papillomavirus (HPV) related Head and Neck squamous cell carcinomas (HN-SCCs) as a separate subgroup among Head and Neck Cancers with different epidemiology, histopathological characteristics, therapeutic response to chemo-radiation treatment and clinical outcome. However, there is not a worldwide consensus on the methods to be used in clinical practice. The endpoint of this study was to demonstrate the reliability of a triple method which combines evaluation of: 1. p16 protein expression by immunohistochemistry (p16-IHC); 2. HPV-DNA genotyping by consensus HPV-DNA PCR methods (Consensus PCR); and 3 viral integration into the host…

From palliation to cure: PIPAC for peritoneal malignancies

2019

Introduction Systemic chemotherapy offers poor control over peritoneal disease, maybe as a consequence of restricted drug availability within the abdominal cavity. Locoregional chemotherapy may overcome these shortcomings but its administration is limited to a few patients with confined peritoneal spread. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) emerged in the last years as a novel method of intraperitoneal drug administration. Evidence acquisition We report a meta-analysis of published studies on PIPAC safety and pathological anti-tumoral efficacy on PC from various tumor entities, with the aim of providing more evidence to support further research. This systematic review a…

Human brain organoids assemble functionally integrated bilateral optic vesicles

2021

During embryogenesis, optic vesicles develop from the diencephalon via a multistep process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain organoids, we attempted to simplify the complexities and demonstrate formation of forebrain-associated bilateral optic vesicles, cellular diversity, and functionality. Around day 30, brain organoids attempt to assemble optic vesicles, which develop progressively as visible structures within 60 days. These optic vesicle-containing brain organoids (OVB-organoids) constitute a developing optic vesicle's cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progeni…

Brief an Garlieb H. Merkel

1799

Ms. 930a, Nr. 8, Bl. 22r-23v Böttiger, Karl August. Brief an Garlieb H. Merkel, Weimar, d[en] 13. November 1797 Autora rokraksts / Autograph, vācu, angļu un latīņu val. / Deutsch, Englisch und Latein [4] lpp. / S. Attēlu numuri / Bildnummern: 930a-008-1 – 930a-008-4 Der Verfasser nennt in diesem inhaltsreichen Brief zahlreiche Namen und hält nicht nur die Verbindung mit Merkel, die aus dessen erstem Aufenthalt in Weimar resultierte, aufrecht, sondern gibt ihm weitere Hinweise und Empfehlung für seinen weiteren Aufenthalt in Dänemark. So rät er zur Übersetzung dreier Romane aus dem Englischen, darunter Jane Wests „A gossip's story“ (London 1796). Ferner bittet der Verfasser Merkel um Gefälli…

Psychosocial Safety Climate and PSC Ideal; Direct and Interaction Effects on JD-R for Mental Health, Job Satisfaction and Work Engagement (Iran)

2019

In this chapter the PSC model is investigated from composition and dispersion perspectives. PSC refers to the shared perception of managerial activities to support employees’ psychological health and safety. Theoretically, PSC extends the Job Demand-Resources (JD-R) theory. Consistent with composition and dispersion theories, both PSC compositions (average levels) and PSC dispersion (standard deviation (SD)) are investigated. PSC Ideal \( \left( {\frac{PSC\;Level}{PSC\, SD}} \right) \) is a new concept being introduced for the first time here, and includes both mean and dispersion roles. We expected that PSC at the team level determined job design (JD-Rs; psychological and emotional demands…

Stima dei costi della sicurezza nei cantieri: ancora troppe incertezze

2009

In vitro and in vivo investigations of osteogenic differentiation ability of dental pulp stem cells (DPSCs) and gingival mesenchymal stem cells (GMSC…

2020

Thanks to the use of human mesenchymal stem cells (hMSCs), smart biomaterials and active biomolecules, Regenerative Medicine (RM) and Bone Tissue Engineering (BTE) can restore structure and function of injured tissues. Among the different sources of hMSCs, the oro-facial hMSCs have promising in vitro and in vivo regeneration potential; in particular, dental pulp and gingiva are valuable sources of autologous hMSCs. The aim of this PhD thesis is testing the in vitro and in vivo bone regeneration ability of hMSCs isolated from dental pulp and inflamed gingiva of periodontally-compromised teeth, up to now considered biological waste tissues and discarded during surgical procedures, on two comm…