Search results for "PSORIASIS"
showing 10 items of 193 documents
Psoriasis moderada-grave en pacientes pediátricos y jóvenes: experiencia en el registro BIOBADADERM
2022
Resumen {0>El debut de la psoriasis en la edad pediatrica, aunque generalmente leve, puede requerir tratamiento sistemico en las formas moderadas o graves de la enfermedad. Childhood-onset psoriasis generally follows an indolent course but patients with moderate or severe disease may require systemic treatment. El objetivo de este trabajo es analizar la frecuencia relativa, las caracteristicas de los pacientes, el tratamiento empleado y los eventos adversos (EA) observados a partir del registro BIOBADADERM en ninos y jovenes con psoriasis moderada-grave. The aim of this study was to determine the relative proportion of children and young people aged up to 21 years with moderate to severe ps…
396 Ciclosporine therapy for psoriasis leading to fathering of a healthy child in a previously infertile male
2017
Zur Penetrationskinetik von Dehydroepiandrosteron durch die Erythrocytenmembran
1981
Bei zehn Kranken mit Psoriasis vulgaris und zehn Kontroll-personen wurde die Penetrationskinetik von freiem Dehydroepiandrosteron (DHEA) durch die Erythrocytenmembran und der Metabolismus des penetrierten DHEA untersucht.
Ar veselību saistītas dzīves kvalitātes saistība ar depresijas izplatību pacientiem ar psoriāzi Latvijā
2018
Priekšvēsture. Psoriāzes slimniekiem ir depresijas sastopamība ir paaugstināta un biežāka, salīdzinot ar veseliem iedzīvotājiem. Patfizioloģiskais iemesls psoriāzes biežajai saistībai ar depresiju vēl nav pilnībā noskaidrots. Mērķi. Šī pētījuma mērķis ir novērtēt psoriāzes faktorus, kas ietekmē depresiju. Šis pētījums ir paredzēts, lai palīdzētu noskaidrot dzīves kvalitātes nozīmi depresijas attīstībā. Materiāls un metodes. Lai novērtētu pacientu dzīves kvalitātes saistību ar depresiju, mēs noteicām depresijas līmeni 21 psoriāzes pacientam laika posmā no 2017. gada maija līdz 2018. gada martam, izmantojot dermatoloģijas dzīves kvalitātes indeksa (DLQI) un slimnīcu trauksmes un depresijas sk…
Hepatitis Virus Reactivation in Patients with Psoriasis Treated with Secukinumab in a Real-World Setting of Hepatitis B or Hepatitis C Infection
2022
Background and Objective Biologics for psoriasis, especially anti-tumor necrosis factor-alpha therapies, may reactivate hepatitis B virus (HBV) or hepatitis C virus (HCV) infections, as well in inactive carriers or patients with occult infection. However, some biologics, including anti-interleukin-17 therapies such as secukinumab, seem to be less likely to cause hepatitis reactivation. This study assessed the safety of secukinumab treatment in patients with psoriasis with HBV or HBC infection. Methods This was a retrospective cohort study of patients with moderate-to-severe psoriasis treated with secukinumab at seven Italian centers. Patients serologically positive for one or more of the fo…
Hypoxanthine and purine compounds in plasma from patients with multiple sclerosis and psoriasis
2011
TAP-polymorphisms in juvenile onset psoriasis and psoriatic arthritis.
1996
Abstract Juvenile onset psoriasis is strongly associated with the HLA-class I genes Cw6 and B57 whereas patients with psoriatic arthritis show an increased frequency of HLA-B27. It is unclear whether additional major histocompatibility genes also increase disease susceptibility. The TAP genes (transporter associated with antigen processing) encode two membrane-spanning proteins that translocate antigenic peptides from the cytoplasm into the endoplasmic reticulum. Comparison of 60 patients with juvenile onset psoriasis, 63 psoriatic arthritis patients, and 101 caucasoid controls revealed an increase of the TAP1 ∗ 0101 allele in the psoriasis group, that could not be explained by linkage to o…
Anti-inflammatory Therapies for Cardiovascular Disease: Signaling Pathways and Mechanisms
2019
Cardiovascular diseases (CVD) are the clinical manifestation of atherosclerosis, a chronic inflammatory disease promoted by several risk factors such as dyslipidemia, type 2 diabetes mellitus, hypertension, and smoking. Acute CVD events are the result of an unresolved inflammatory chronic state that promotes the rupture of unstable plaque lesions. Of note, the existing intensive therapies modify risk factors but do not prevent life-threatening recurrent ischemic events in high-risk patients, who have a residual inflammatory risk displayed by increased C-reactive protein (CRP) levels. Better understanding of the role of innate and adaptive immunity in plaque development and rupture has led t…
Advances in antioxidant phytochemical for inflammatory skin diseases: mangiferin and naringin nanocarriers based lipids
2020
Chronic inflammatory skin diseases are the most common topical disorders and the fourth cause of global disability. Among all, psoriasis (PS) and atopic dermatitis (AD) are the most frequent chronic and recurrent inflammatory diseases of the skin. Atopic dermatitis has a strong Th2 factor while psoriasis is a disease driven by Th17. The actual treatment, which involve the combination of topical, systemic and biological therapy, is characterized by numerous adverse effects, which reduce patient compliance, lead to the limitation of long-term use and limit the therapeutic efficacy. Therefore, there is a great need for the continuous development of novel, effective and safe coadjuvant treatmen…