Search results for "PTM"

showing 10 items of 14 documents

Zum Akademiestreit als eine Stufe auf dem Weg des Künstlers in sich selbst. Carl Hauptmanns "Einhart der Lächler"

2016

W powieści „Einhart der Lächler“ Carl Hauptmann opisuje drogę życiową artysty, która okazuje się poszukiwaniem własnej tożsamości. Carl Hauptmann ubiera swą opowieść w popularną formę powieści edukacyjnej. Droga Einharta prowadzi przez instytucje sztuki, wówczas napiętnowane przez konflikt pomiędzy wykształceniem akademickim artysty a jego kreatywną wolnością. Poniższy tekst koncentruje się na osadzeniu tego napięcia w ramach historycznych. W dalszej części przedstawione zostaną powiązania głównego bohatera z zaprzyjaźnionym z Carlem Hauptmannem malarzem – Otto Muellerem.

"Einhart der Lächler”Akademia Sztuk Pięknych we WrocławiucyganeriaAkademia Sztuk Pięknychexpressionismartist"Einhart der Lächler"Carl HauptmannBohemiaartystaOtto Muellerthe Academy of Fine Arts in WroclawekspresjonizmAcademy of Fine Arts
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Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation

2021

Arginine-glycine(-glycine) (RG/RGG) regions are highly abundant in RNA-binding proteins and involved in numerous physiological processes. Aberrant liquid-liquid phase separation (LLPS) and stress granule (SGs) association of RG/RGG regions in the cytoplasm have been implicated in several neurodegenerative disorders. LLPS and SG association of these proteins is regulated by the interaction with nuclear import receptors, such as transportin-1 (TNPO1), and by post-translational arginine methylation. Strikingly, many RG/RGG proteins harbour potential phosphorylation sites within or close to their arginine methylated regions, indicating a regulatory role. Here, we studied the role of phosphoryla…

CIRBPphosphorylationPTMsQH301-705.5SRPK1RNA-binding proteinsBiology (General)arginine methylationFrontiers in Molecular Biosciences
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Moritz Hauptmann in München. Hochschuldidaktik im 19. Jahrhundert

2014

Dass Moritz Hauptmanns Buch Die Natur der Harmonik und der Metrik zur Basis institutionalisierter musiktheoretischer Unterweisung wurde, wie an der Koniglich bayerischen Musikschule in Munchen nachweisbar, mag angesichts des hohen Abstraktionsgrads dieser Schrift verwundern. Besonders der Unterricht in der ersten Dekade an der Musikschule kann als einzigartiges Exempel der systematischen Anwendung Hauptmanns in der Lehre verstanden werden. Der Beitrag erortert die Bedeutung der Schrift Hauptmanns fur die Lehre der wichtigsten Fachvertreter nach Grundung der Musikschule (Peter Cornelius und Josef Gabriel Rheinberger), sowie – als Verfallsgeschichte – in der Zeit nach Cornelius’ fruhem Tod un…

Cyrill KistlerHarmonielehrelcsh:Music and books on MusicPhilosophyMünchener SchuleEarly deaththeory of harmonyTheologyHarmonielehre; theory of harmony; Cyrill Kistler; Moritz Hauptmann; Münchener Schule; Peter Cornelius; Josef Gabriel Rheinbergerlcsh:MPeter CorneliusMoritz HauptmannJosef Gabriel RheinbergerZeitschrift der Gesellschaft für Musiktheorie [Journal of the German-Speaking Society of Music Theory]
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SARS CoV2 infection _The longevity study perspectives

2021

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MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Tetrathiafulvalene-Polychlorotriphenylmethyl Dyads: Influence of Bridge and Open-Shell Characteristics on Linear and Nonlinear Optical Properties

2017

Three conjugated donor-π-acceptor radical systems (1 a–1 c) were prepared by bridging a tetrathiafulvalene (TTF) electron-donor unit to a polychlorotriphenylmethyl (PTM) electron-acceptor radical through vinylene units of different lengths. The dependence of the intramolecular charge transfer on the length of the conjugated bridge has been analyzed by different electrochemical and spectroscopic techniques. Linear optical properties and the second-order nonlinear optical (NLO) response of these derivatives have been computed by comparing systems 1 a–1 c with the non-radical analogues (2 a–2 c). Interestingly, an enhanced NLO response is predicted for dyads 1 a–1 c with PTM in the radical for…

Nonlinear opticsRadicalConjugated system010402 general chemistryPhotochemistry01 natural sciencesCatalysischemistry.chemical_compoundDonor–acceptor complexesOpen shellchemistry.chemical_classification010405 organic chemistryOrganic ChemistryNonlinear opticsGeneral ChemistryElectron acceptorAcceptor3. Good health0104 chemical sciencesCrystallographychemistryIntramolecular forceTetrathiafulvaleneIntramolecular charge transferPTM radicalsTetrathiafulvaleneChemistry - A European Journal
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Editorial: The Role of Protein Post-Translational Modifications in Protein-RNA Interactions and RNP Assemblies

2022

RNP granulesEditorialQH301-705.5Molecular BiosciencesRNA-protein interactionsPTMs (post-translational modifications)phase separationBiology (General)Biochemistry Genetics and Molecular Biology (miscellaneous)Molecular BiologyBiochemistryintrinsically disordered region (IDR)Frontiers in Molecular Biosciences
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Lévy Flights for Ant Colony Optimization in Continuous Domains

2009

In this paper, the authors propose the use of the Levy probability distribution as leading mechanism for solutions differentiation in an efficient and bio-inspired optimization algorithm, ant colony optimization in continuous domains, ACOR. In the classical ACOR, new solutions are constructed starting from one solution, selected from an archive, where Gaussian distribution is used for parameter diversification. In the proposed approach, the Levy probability distributions are properly introduced in the solution construction step, in order to couple the ACOR algorithm with the exploration properties of the Levy distribution.

Settore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniLévy flights Ant colony optimization continuous domains optmization
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Shakedown design of structures under dynamic loading

2010

The optimal (minimum volume) design of elastic plastic structures under static and dynamic loads is studied. The minimum volume design is reached accounting for different resistance limits: it is required that the optimal structure simultaneously satisfies the elastic shakedown limit and the instantaneous collapse limit, or alternatively the elastic and the plastic shakedown limits, adopting for each limit condition a suitably chosen load combination and some appropriate load amplifiers. The load combinations are characterized by the presence of fixed loads, quasi-statical cyclic loads and dynamic (seismic) loads. Reference is made to the Italian Code related to structural analysis and desi…

Shakedown dessign dynamic loading optmal designSettore ICAR/08 - Scienza Delle Costruzioni
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Grafting of (3-chloropropyl)-trimethoxy silane on halloysite nanotubes surface

2021

Modified halloysite nanotubes (HNTs-Cl) were synthesized by a coupling reaction with (3-chloropropyl) trimethoxysilane (CPTMS). The incorporation of chloro-silane onto HNTs surface creates HNTs-Cl, which has great chemical activity and is considered a good candidate as an active site that reacts with other active molecules in order to create new materials with great applications in chemical engineering and nanotechnology. The value of this work lies in the fact that improving the degree of grafting of chloro-silane onto the HNT’s surface has been accomplished by incorporation of HNTs with CPTMS under different experimental conditions. Many parameters, such as the dispersing media, the molar…

TechnologyMaterials scienceQH301-705.5QC1-999CPTMS020101 civil engineering02 engineering and technologyengineering.materialHalloysiteSettore CHIM/12 - Chimica Dell'Ambiente E Dei Beni Culturali0201 civil engineeringCatalysischemistry.chemical_compoundAdsorptionGRAFTINGGeneral Materials ScienceBiology (General)InstrumentationTriethylamineQD1-999Fluid Flow and Transfer ProcessesHALLOYSITE NANOTUBESGraftingHalloysite nanotubesProcess Chemistry and TechnologyTPhysicsGeneral Engineering021001 nanoscience & nanotechnologyGraftingEngineering (General). Civil engineering (General)SilaneComputer Science ApplicationsAmmonium hydroxideChemistrychemistryChemical engineeringengineeringSurface modificationTA1-20400210 nano-technology
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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

2013

Journal article TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10!-7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10!-8) and BRCA1 mutation carrier (P = 1.1 × 10!-5) breast cancers and altered promot…

TelomeraseMessengerCàncer d'ovariEstrogen receptorAetiology screening and detection [ONCOL 5]0302 clinical medicineBreast cancerRisk FactorsAlternative Splicing; Biomarkers Tumor; Breast Neoplasms; Case-Control Studies; Chromatin; DNA Methylation; Female; Gene Expression Profiling; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Luciferases; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Polymorphism Single Nucleotide; RNA Messenger; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Telomerase; Telomere; GeneticsGenotypeBUCCAL CELLSLuciferasesTelomeraseOligonucleotide Array Sequence AnalysisOvarian Neoplasms0303 health sciencesTumorTelòmerReverse Transcriptase Polymerase Chain ReactionGENETIC-VARIATIONCOMMON VARIANTSSingle Nucleotidetert-clptm1l locus; genome-wide association; genetic-variation; susceptibility loci; buccal cells; fibroblasts; common variants; carcinoma; reverse-transcriptase htert; metaanalysisTelomereAetiology screening and detection Immune Regulation [ONCOL 5]Chromatin3. Good healthTumor Markers Biological030220 oncology & carcinogenesisFemaleFIBROBLASTSGenotypeSUSCEPTIBILITY LOCICARCINOMASingle-nucleotide polymorphismBreast NeoplasmsBiologyReal-Time Polymerase Chain ReactionPolymorphism Single NucleotideArticleCàncer de mama03 medical and health sciencesBreast cancerSDG 3 - Good Health and Well-beingTranslational research [ONCOL 3]Ovarian cancermedicineGeneticsBiomarkers TumorHumansGenetic Predisposition to DiseaseRNA MessengerPolymorphismAlleleGENOME-WIDE ASSOCIATIONMETAANALYSIS030304 developmental biologyMolecular epidemiology Aetiology screening and detection [NCEBP 1]Breast cancer susceptibilityHereditary cancer and cancer-related syndromes [ONCOL 1]Translational research Genomic disorders and inherited multi-system disorders [ONCOL 3]Gene Expression ProfilingDNA Methylationmedicine.diseaseMolecular biologyTERT-CLPTM1L LOCUSTelomereMinor allele frequencyAlternative SplicingGenetic LociCase-Control StudiesRNABiomarkersREVERSE-TRANSCRIPTASE HTERTGenome-Wide Association StudyNature genetics
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