Search results for "PTO"

Endocrine disrupters: the new players able to affect the epigenome

2015

Epigenetics represents the way by which the environment is able to program the genome; there are three main levels of epigenetic control on genome: DNA methylation, post-translational histone modification and microRNA expression. The term Epigenetics has been widened by NIH to include “both heritable changes in gene activity and expression but also stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable.” These changes might be produced mostly by the early life environment and might affect health influencing the susceptibility to develop diseases, from cancer to mental disorder, during the entire life span. The most studied environmental i…

Halogen-Bonded Co-Crystals of Aromatic N-oxides : Polydentate Acceptors for Halogen and Hydrogen Bonds

2017

The C-ethyl-2-methylresorcinarene (1) forms 1:1 in-cavity complexes with aromatic N,N′-dioxides, only if each of the aromatic rings has an N−O group. The structurally different C-shaped 2,2′-bipyridine N,N′-dioxide (2,2′-BiPyNO) and the linear rod-shaped 4,4′-bipyridine N,N′-dioxide (4,4′-BiPyNO) both form 1:1 in-cavity complexes with the host resorcinarene in C4v crown and C2v conformations, respectively. In the solid state, the host–guest interactions between the 1,3-bis(4-pyridyl)propane N,N′-dioxide (BiPyPNO) and the host 1 stabilize the unfavorable anti-gauche conformation. Contrary to the N,N′-dioxide guests, the mono-N-oxide guest, 4-phenylpyridine N-oxide (4PhPyNO), does not form an…

Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase

2018

Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such…

Determinación de Streptococcus Mutans y Streptococcus Sobrinus, mediante pcr cuantitativa a tiempo real, y su relación con la caries dental en escola…

2013

La caries dental presenta una etiología multifactorial, los factores ambientales, los hábitos de alimentación, higiene bucal y la susceptibilidad genética individual, juegan un papel importante en el desarrollo de esta enfermedad (1). Los Streptococcus mutans y Streptococcus sobrinus están fuertemente implicados en la aparición de la caries dental en humanos. Numerosos estudios han demostrado que la asociación de S. mutans y S. sobrinus conlleva niveles más altos de caries (2-4) y varios estudios han encontrado que la prevalencia deS. sobrinus está fuertemente asociada con mayor actividad de caries que la delS. mutans (5-6). Se considera que la determinación de estas dos especies en la infa…

Regulatory networks underlying mycorrhizal development delineated by genome-wide expression profiling and functional analysis of the transcription fa…

2017

Background: Ectomycorrhizal (ECM) fungi develop a mutualistic symbiotic interaction with the roots of their host plants. During this process, they undergo a series of developmental transitions from the running hyphae in the rhizosphere to the coenocytic hyphae forming finger-like structures within the root apoplastic space. These transitions, which involve profound, symbiosis-associated metabolic changes, also entail a substantial transcriptome reprogramming with coordinated waves of differentially expressed genes. To date, little is known about the key transcriptional regulators driving these changes, and the aim of the present study was to delineate and functionally characterize the trans…

Polysarcosine-Based Lipids: From Lipopolypeptoid Micelles to Stealth-Like Lipids in Langmuir Blodgett Monolayers.

2016

Amphiphiles and, in particular, PEGylated lipids or alkyl ethers represent an important class of non-ionic surfactants and have become key ingredients for long-circulating (“stealth”) liposomes. While poly-(ethylene glycol) (PEG) can be considered the gold standard for stealth-like materials, it is known to be neither a bio-based nor biodegradable material. In contrast to PEG, polysarcosine (PSar) is based on the endogenous amino acid sarcosine (N-methylated glycine), but has also demonstrated stealth-like properties in vitro, as well as in vivo. In this respect, we report on the synthesis and characterization of polysarcosine based lipids with C14 and C18 hydrocarbon chains and their end g…

TEMPORAL CHANGES IN RESPIRATORY SYMPTOMS/DISEASES AND ASSOCIATED RISK FACTORS IN REAL LIFE

Background: The prevalence of respiratory diseases increased during last centuries and the rapid rise in the prevalence of such diseases cannot be explained by genetic factors. Analyses on general population samples investigated at interval of some years can permit to better comprehend these increases and the associated risk factors, adding new evidences on this important item taking into account the real life setting. Aims: to assess real life temporal changes in respiratory diseases/symptoms (asthma, allergic rhinitis - AR - and chronic obstructive pulmonary disease - COPD) and associated risk factors in general population samples investigated during a period of 30 years. Methods: a gener…

Effects of pyrolysis temperature on the hydrologically relevant porosity of willow biochar

2018

Biochar pore space consists of porosity of multiple length scales. In direct water holding applications like water storage for plant water uptake, the main interest is in micrometre-range porosity since these pores are able to store water that is easily available for plants. Gas adsorption measurements which are commonly used to characterize the physical pore structure of biochars are not able to quantify this pore-size range. While pyrogenetic porosity (i.e. pores formed during pyrolysis process) tends to increase with elevated process temperature, it is uncertain whether this change affects the pore space capable to store plant available water. In this study, we characterized biochar poro…

Kriptovalūtu statistiskās īpašības un to portfeļa optimizēšana

2018

Bakalaura darbā aprakstīta, mūsdienu, viena no populārākajām valūtām-kriptovalūta, kas pēdējo gadu laikā, ir izraisījusi lielu interesi investoru un spekulantu vidū. Darbā tiks apskatīta lielākā no kriptovalūtām Bitcoin un tās statistiskās īpašības. Tākā kriptovalūtai piemīt daudzas valūtai raksturīgās īpašības, to var uzsskatīt par finanšu instrumentu. Šajā darbā tiks izklāstīts, kā izveidot optimālu portfeli, pielietojot plašāk pazīstamās portfeļu optimizācijas metodes.

Método de cálculo de la potencia de la lente intraocular pseudofáquica en pacientes intervenidos previamente de cirugía refractiva corneal láser

2018

Antecedentes: El valor de la potencia de la lente intraocular (PLIO) que sustituirá al cristalino en una cirugía de cataratas o lensectomía refractiva, es una función de la longitud axial (LA), la posición efectiva de la lente (PEL) y la potencia corneal (PC). Estas variables se introducen en una fórmula que proporciona el valor preciso de la PLIO para alcanzar el resultado refractivo programado. En ojos sin cirugías corneales previas, el resultado refractivo tras el implante es el esperado, con pequeños errores no significativos clínicamente. Sin embargo, cuando se calcula la PLIO en pacientes intervenidos previamente de cirugía refractiva corneal láser (CRCL), el resultado no es tan preci…