Search results for "Pain medicine"

Perfiles de resistencia y factores de riesgo de microorganismos resistentes en bacteriemia de origen abdominal

2017

Resumen Objetivo La presencia de microorganismos resistentes es una causa importante de fallo en el tratamiento antimicrobiano inicial. Los objetivos de este estudio son conocer el perfil de resistencia de los microorganismos causantes de bacteriemia de origen abdominal e identificar si el uso previo de antibioticos y el lugar de adquisicion de la bacteriemia son factores de riesgo para determinar la presencia de microorganismos resistentes. Material y metodo Se diseno un estudio de cohorte retrospectiva de todos los pacientes adultos que presentaron bacteriemia y/o fungemia cuyo foco infeccioso primario fue de origen abdominal ingresados en un hospital universitario durante los anos 2011-2…

Análisis de casos de candidemia por Candida auris en una Unidad de Cuidados Intensivos de Anestesia en un hospital terciario

2021

Resumen Candida auris es una levadura emergente multirresistente. Objetivos Analizar la relacion entre la existencia de colonizacion por C. auris y la aparicion de candidiasis invasora. Descripcion de la muestra de pacientes colonizados, factores de riesgo para colonizacion y/o infeccion y calculo de las tasas de mortalidad. Metodologia Estudio observacional longitudinal en una Unidad de Cuidados Intensivos de Anestesia durante el ano 2018. Resultados Ingresaron 2.130 pacientes; 124 pacientes tuvieron estudios de vigilancia positivos, 118 casos fueron colonizacion cutanea y 52 faringea. Se identificaron los pacientes con hemocultivo positivo. Se encontro asociacion estadisticamente signific…

Triptans and CGRP blockade - impact on the cranial vasculature.

2017

Abstract The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide (CGRP), which modulate pain transmission and vascular tone. Thirty years after discovery of agonists for serotonin 5-HT1B and 5-HT1D receptors (triptans) and less than fifteen after the proof of concept of the gepant class of CGRP receptor antagonists, we are still a long way from understanding their precise site and mode of action in migraine. The effect on cranial vasculature is relevant, because all specific anti-migraine drugs and mig…

PACAP38 and PAC1 receptor blockade: a new target for headache?

2018

Abstract Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent inducer of migraine-like attacks, but the mechanism behind this has not been fully elucidated. Migraine is a neurovascular disorder, recognized as the second most disabling disease. Nevertheless, the antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor are the only prophylactic treatment developed specifically for migraine. These antibodies have displayed positive results in clinical trials, but are not effective for all patients; therefore, new pharmacol…

Noninvasive ventilation for acute hypoxemic respiratory failure/ARDS: The show must go on

2018

Should we administer antifungal drugs before the diagnosis of invasive fungal infection in non-neutropenic critically ill patients?

2016

Blocking CGRP in migraine patients – a review of pros and cons

2017

Abstract Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine include drugs developed for diseases other than migraine such as hypertension, depression and epilepsy. During the last decade, however, blocking calcitonin gene-related peptide (CGRP) has emerged as a possible mechanism for prevention of migraine attacks. CGRP has been shown to be released during migraine attacks and it may play a causative role in induction of migraine attacks. Here, we review the pros and cons of blocking CGRP in migraine patients. To date, two different classes of drugs blocking CGRP have been developed: …

What’s new on emerging resistant Candida species

2018

In Defense of Sympathy, in Consideration of Empathy, and in Praise of Compassion: A History of the Present.

2017

Thérapie d’acceptation et d’engagement (ACT) et Mindfulness, un modèle de flexibilité psychologique pour la douleur chronique

2016

Resume La therapie d’acceptation et d’engagement (ACT) et la meditation en pleine conscience appelee egalement Mindfulness sont issues de la troisieme vague des therapies comportementales et cognitives (TCC). Bien que ces therapies aient suscite l’interet des cliniciens et chercheurs internationaux et qu’elles beneficient a present de solides supports empiriques appliques au domaine de la douleur chronique, l’ACT et le Mindfulness restent encore meconnus en France et encore trop peu utilises pour reduire la souffrance des patients douloureux chroniques. Nous presenterons, dans cet article, les concepts theoriques de la therapie d’ACT et du Mindfluness, illustres d’exemples cliniques, mais e…