Search results for "Peg"
showing 10 items of 460 documents
A facile and eco-friendly route to fabricate poly(Lactic acid) scaffolds with graded pore size
2016
Over the recent years, functionally graded scaffolds (FGS) gaineda crucial role for manufacturing of devices for tissue engineering. The importance of this new field of biomaterials research is due to the necessity to develop implants capable of mimicking the complex functionality of the various tissues, including a continuous change from one structure or composition to another. In this latter context, one topic of main interest concerns the design of appropriate scaffolds for bone-cartilage interface tissue. In this study, three-layered scaffolds with graded pore size were achieved by melt mixing poly(lactic acid) (PLA), sodium chloride (NaCl) and polyethylene glycol (PEG). Pore size distr…
Poly(ethylenglycol) mimics adhesive capability of the ECM treatment on 3D polylactide-based scaffolds to study in vitro human hepatocarcinoma process…
2011
Postmodern impegno. Ethics and Commitment in Contemporary Italian Culture
2010
Recensione a P. Antonello, F. Mussgnug (a cura di), Postmodern impegno. Ethics and Commitment in Contemporary Italian Culture, Peter Lang, Bern, 2009
Crystallization and preliminary X-ray studies of oligandrin, a sterol-carrier elicitor fromPythium oligandrum
2000
Oligandrin is a 10 kDa acidic protein produced by the fungus micromycete Pythium oligandrum and is a member of the alpha-elicitin group, with sterol- and lipid-carrier properties. Oligandrin has been crystallized at 290 K using PEG 4000 as a precipitant. A cholesterol complex was obtained under the same conditions. The space group of the crystals at low temperature (100 K) is C222, with unit-cell parameters a = 94.0, b = 171.1, c = 55.3 A. Four molecules are present in the asymmetric unit. Data from the free and cholesterol-complexed forms were recorded at synchrotron sources to resolutions of 2.4 (uncomplexed) and 1.9 A (complexed), respectively.
Hydrophilicity Regulates the Stealth Properties of Polyphosphoester‐Coated Nanocarriers
2018
Increasing the plasma half-life is an important goal in the development of drug carriers, and can be effectively achieved through the attachment of polymers, in particular poly(ethylene glycol) (PEG). While the increased plasma half-life has been suggested to be a result of decreased overall protein adsorption on the hydrophilic surface in combination with the adsorption of specific proteins, the molecular reasons for the success of PEG and other hydrophilic polymers are still widely unknown. We prepared polyphosphoester-coated nanocarriers with defined hydrophilicity to control the stealth properties of the polymer shell. We found that the log P value of the copolymer controls the composit…
Organizzazioni del terzo settore
2021
When referring to migrants, the collective representation sees them as recipients of services offered by the third sector and not, in the first instance, as actors actively engaged in associative processes. Addressing the issue of the relationship between migrants and the third sector implies, therefore, proposing a change of perspective that leads to think of migrants (also this rather wide category) not as direct beneficiaries, as victims in need, but as protagonists actively engaged in the institutions or as collaborators, experts, employees, therefore paid, or as volunteers, free of charge.
An Open-Label Trial of 12-Week Simeprevir plus Peginterferon/Ribavirin (PR) in Treatment-Naïve Patients with Hepatitis C Virus (HCV) Genotype 1 (GT1)
2016
Background: Shortening duration of peginterferon-based HCV treatment reduces associated burden for patients. Primary objectives of this study were to assess the efficacy against the minimally acceptable response rate 12 weeks post-treatment (SVR12) and safety of simeprevir plus PR in treatment-naïve HCV GT1 patients treated for 12 weeks. Additional objectives included the investigation of potential associations of rapid viral response and baseline factors with SVR12. Methods: In this Phase III, open-label study in treatment-naïve HCV GT1 patients with F0-F2 fibrosis, patients with HCV-RNA 12-week regimen. Conclusions: Overall SVR12 rate (66%) was below the target of 80%, indicating that sho…
Factors affecting the amount and the mode of merocyanine 540 binding to the membrane of human erythrocytes. A comparison with the binding to leukemia…
1995
Abstract In the presence of albumin Merocyanine 540 (MC540) exhibits a very limited binding to the outer surface of the membrane of normal erythrocytes, whereas pronounced binding is observed to leukemia cells. To find out whether this difference is due to differences in the composition or structural organization of the cell membrane we analyzed effects of a number of covalent and non-covalent perturbations of the red cell membrane on the binding and fluorescence characteristics of membrane-bound MC540. It is shown that exposure of the cells to cationic chlorpromazine, neuraminidase or photodynamic treatment with AlPcS 4 as sensitizer caused a limited increase (30–50%) of MC540 binding, tog…
La tavolozza di Don Chisciotte: il carteggio Sciascia-Guccione
2023
Trought the unpublished correspondence between Leonardo Sciascia and Piero Guccione (1975-1989), is possible to analyse the intrinsec relationship between aesthetics and ethics, artistic vein and civil engagement, but also to retrace Sciascia’s controversies in the 1970s, thus illustrating the antagonistic and conflictual relationship between intellectuals and power.
Sekvenču līdzināšanas attēlojuma datņu saspiešanas rīka iespējamie uzlabojumi MPEG-G standartam
2021
Darba mērķis ir apskatīt datu saspiešanu genomisko datu datņu standartizācijas projektā MPEG-G, identificēt kādus uzlabojumus tajā iespējams veikt, un tos realizēt. Veikts literatūras apskats par MPEG-G standartu un bezzudumu datu saspiešanas algoritmiem. Identificēts, realizēts un profilēts iespējams uzlabojums. Viens no kandidātiem MPEG-G sekvenču līdzinājuma datņu saspiešanai – programma tsc izmanto datu saspiešanas bibliotēku zlib, kas savukārt izmanto DEFLATE datu saspiešanas algoritmu. Darbā apskatītas potenciālās alternatīvas zlib, viena no tām – zstd - ieviesta tsc, tās veikums profilēts un salīdzināts ar oriģinālās tsc versijas sniegumu. Izmainītā tsc versija iegūst vidēji 3% lielā…