Search results for "Peg"
showing 10 items of 460 documents
Treating chronic hepatitis C in daily practice with PEG-IFN alfa2B and ribavirin. An Italian multicentre study
2004
Retreatment with pegylated interferon plus ribavirin of chronic hepatitis C non-responders to interferon plus ribavirin: A meta-analysis.
2009
BACKGROUND/AIMS: Efficacy of retreatment with pegylated interferon (PEG-IFN) plus ribavirin of non-responders to standard or pegylated IFN plus ribavirin has been assessed in various studies, but sustained virologic response (SVR) rates are variable and factors influencing efficacy and tolerability still remain incompletely defined. We aimed to focus on SVR rates and to identify factors influencing them in this meta-analysis. METHODS: MEDLINE as well as a manual search were used. Studies were included if they were controlled or uncontrolled trials, if they had been published as full-length papers and if they included non-responders to standard or pegylated IFN and ribavirin therapy. Fourtee…
Inulin-Based Polymeric Micelles Functionalized with Ocular Permeation Enhancers: Improvement of Dexamethasone Permeation/Penetration through Bovine C…
2021
Ophthalmic drug delivery is still a challenge due to the protective barriers of the eye. A common strategy to promote drug absorption is the use of ocular permeation enhancers, while an innovative approach is the use of polymeric micelles. In the present work, the two mentioned approaches were coupled by conjugating ocular permeation enhancers (PEG2000, carnitine, creatine, taurine) to an inulin-based co-polymer (INU-EDA-RA) in order to obtain self-assembling biopolymers with permeation enhancer properties for the hydrophobic drug dexamethasone (DEX). Inulin derivatives were properly synthetized, were found to expose about 2% mol/mol of enhancer molecules in the side chain, and resulted abl…
Antecedentes y efectos del apego a la marca: papel moderador del posicionamiento de marca por atributo preeminente y de la implicación en la categorí…
2017
Cada día estamos expuestos a mayor cantidad de marcas, pocas sobresalen y menos aún generan apego emocional en sus usuarios. Aquellas que logran generar el apego emocional de sus consumidores, se benefician no solamente en cuanto a preferencia, lealtad y recompra, sino además en recomendaciones positivas, disposición a pagar un valor más alto por sus consumidores para poseerlas, y hasta tolerancia mayor con errores que la marca puede cometer. En este marco, la presente tesis persigue tres objetivos: (i) Explorar el impacto que cuatro antecedentes (personalidad de la marca, calidad percibida, notoriedad de marca y credibilidad de marca) y tres efectos (lealtad, intención de compra y riesgo p…
Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy
2020
Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration. The polycation was synthesized by derivatization of &alpha
Realization of polyaspartamide-based nanoparticles and in vivo lung biodistribution evaluation of a loaded gucocorticoid after aerosolization in mice
2016
Abstract In this study, novel polymeric nanoparticles (NPs) were developed and their potential as carriers for beclomethasone dipropionate (BDP) into the lung after aerosolization was demonstrated by in vivo studies in mice. In particular, these NPs were obtained starting from two polyaspartamide-based copolymers which were synthesized by chemical reaction of α,β-poly(N-2-hydroxyethyl)- dl -aspartamide (PHEA) and its pegylated derivative (PHEA-PEG2000) with poly(lactic acid) (PLA). To obtain nanosized particles, the high pressure homogenization (HPH)—solvent evaporation method was followed by using an organic phase containing both PHEA-PLA and PHEA-PEG2000-PLA (at a weight ratio equal to 1:…
La Pira Giorgio
2010
Giorgio La Pira (Pozzallo 1904- Firenze 1977).Le innumerevoli attività di La Pira supportate da un profondo pensiero religioso e filosofico.
La dimensione socio-politica nel pensiero e nell'azione di Mario Sturzo
2018
Mario Sturzo, bishop and philosopher, was a protagonist of the early 1900’s ecclesial renewal of Sicily in his effort to find a new relationship between the Church and the modern world, Christianity and politics. Obstructed by both the civil authorities and by the clergy, he firmly believed in the utmost need of an intellectual formation of both Church and society. Regenerating the mentality of and delivering freedom to men are both essential dimensions of the same task for the sake of the social welfare of the lower classes.
Erri De Luca l'invincibile
2008
Erri de Luca évoque son engagement politique dans la gauche extraparlementaire dans de nombreux textes relevant de différents genres et régimes discursifs: essais, récits fictionnels, autobiographiques, témoignages etc. S'il ne désavoue dans aucun de ses textes les valeurs révolutionnaires pour lesquelles il a combattu et ne cesse de protester de sa solidarité à l'égard des anciens compagnons condamnés et incarcérés, il aborde également la question de la responsabilité individuelle et collective inhérente à toute action politique violente et s'interroge sur l'issue hautement problématique de ces années de lutte.