Search results for "Pegylation"

showing 2 items of 32 documents

Physicochemical Properties of A New PEGylated Polybenzofulvene Brush for Drug Encapsulation

2019

A new polymer brush was synthesized by spontaneous polymerization of benzofulvene macromonomer 6-MOEG-9-T-BF3k bearing a nona(ethylene glycol) side chain linked to the 3-phenylindene scaffold by means of a triazole heterocycle. The polymer structure was studied by SEC-MALS, NMR spectroscopy, and MALDI-TOF MS techniques, and the results supported the role of oligomeric initiatory species in the spontaneous polymerization of polybenzofulvene derivatives. The aggregation features of high molecular weight poly-6-MOEG-9-T-BF3k-FE were investigated by pyrene fluorescence analysis, dynamic light scattering studies, and transmission electron microscopy, which suggested a tendency towards the format…

lcsh:RS1-441Pharmaceutical ScienceAffinity polymerization; Drug delivery systems; Grafting through; Nanocarrier; PEGylation; Polybenzofulvene; Spontaneous polymerization02 engineering and technology010402 general chemistryPolymer brush01 natural sciencesArticlelcsh:Pharmacy and materia medicadrug delivery systemschemistry.chemical_compoundDynamic light scatteringSide chaindrug delivery systemchemistry.chemical_classificationaffinity polymerizationgrafting throughpolybenzofulvenePEGylationPolymer021001 nanoscience & nanotechnologyMacromonomer0104 chemical sciencesspontaneous polymerizationPolymerizationchemistryChemical engineeringPEGylation; grafting through; polybenzofulvene; nanocarrier; drug delivery systems; spontaneous polymerization; anity polymerizationDrug deliverynanocarrier0210 nano-technologyEthylene glycolPharmaceutics
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Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

2020

Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration. The polycation was synthesized by derivatization of &alpha

polyaspartamidelcsh:RS1-441Pharmaceutical Science02 engineering and technologyArticlelcsh:Pharmacy and materia medica03 medical and health scienceschemistry.chemical_compoundpolyaminePEG ratioCopolymerpegylationDerivatization030304 developmental biologySTAT6polyplexechemistry.chemical_classification0303 health sciencesintegumentary systemMucinpolyplexesBiological membranePolymerasthma021001 nanoscience & nanotechnologychemistrysiRNABiophysicsPEGylationAmine gas treating0210 nano-technology
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