Search results for "Pf"
showing 10 items of 526 documents
HACANCOi : a new Hα-detected experiment for backbone resonance assignment of intrinsically disordered proteins
2020
AbstractUnidirectional coherence transfer is highly efficient in intrinsically disordered proteins (IDPs). Their elevated ps-ns timescale dynamics ensures long transverse (T2) relaxation times allowing sophisticated coherence transfer pathway selection in comparison to folded proteins. 1Hα-detection ensures non-susceptibility to chemical exchange with the solvent and enables chemical shift assignment of consecutive proline residues, typically abundant in IDPs. However, many IDPs undergo a disorder-to-order transition upon interaction with their target protein, which leads to the loss of the favorable relaxation properties. Long coherence transfer routes now result in prohibitively large dec…
Mimonoside D: a new triterpenoid saponin from Mimosa diplotricha Sauvalle (Fabaceae)
2021
A new triterpenoid saponin (Mimonoside D: 3-O-��-L-arabinopyranosyl-3��-hydroxyolean-12-en-28-oic acid 28-O-��-D-xylopyranosyl-(1���2)-��-D- glucopyranoside ester (1)) was isolated from the aerial parts of Mimosa diplotricha Sauvalle together with nine known compounds: 7,4���-dihydroxyflavone (2), kaempferol (3), lupeol (4), betulinic acid (5), ��-sitosterol (6), ��-sitosterol-3-O-��-D-glucopyranoside (7), lutein (8), 5,2���-dihydroxy-7,4���,5���-trimethoxyflavone (9) and vitexin (10). Their structures were elucidated on the basis of spectroscopic (1 D and 2 D nuclear magnetic resonance) and high-resolution mass spectrometric data as well as by comparison of their spectral data with those o…
Association between osteocalcin and cognitive performance in healthy older adults.
2016
INTRODUCTION: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.METHODS: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor …
Coppie omosessuali e tutela costituzionale
2015
Le coppie di fatto e quelle omosessuali in particolare sono da tempo una componente della società italiana. La Corte europea dei diritti dell'uomo nella sentenza Schalk and Kopf del 2010 ha riconosciuto la relazione omosessuale come una delle possibili manifestazioni della vita privata e familiare, la cui tutela è sancita dall'art. 8 Cedu. Anche la Corte costituzionale italiana ha attribuito alla relazione omosessuale la connotazione di "formazione sociale", i cui diritti inviolabili sono riconosciuti e garantiti in base all'art. 2 della Costituzione. In questo quadro, stona l'inerzia del legislatore italiano, incapace sino ad ora di disciplinare anche le semplici relazioni di fatto, indipe…
Sicurezza alimentare e salute pubblica al bivio della «nocività» degli alimenti: spunti critici sul d.d.l. n. 2427 del 2020
2022
L’articolo analizza le modifiche operate dal disegno di legge n. 2427/2020 (“Nuove norme in materia di illeciti agro-alimentari”) sui delitti del c.p. contro la salute pubblica e sugli illeciti alimentari della legge n. 283/1962. Si evidenziano profili di incoerenza sistematica e un deficit di coordinamento tra i due distinti piani di tutela. In primo luogo, non è chiara la demarcazione tra le fattispecie delittuose di cui all’art. 5 della legge n. 283/1962 e i delitti codicistici contro la salute pubblica. In secondo luogo, non appare del tutto netta la distinzione tra i reati del citato art. 5 e gli illeciti amministrativi pure previsti dalla legge speciale del 1962. Il nodo più critico s…
Caracterización inmunofenotípica del cáncer de cuello uterino asociado a la infección por Virus Papiloma Humano (HPV)
2006
Se llevó a cabo un estudio inmunohistoquímico incluyendo un panel de 18 biomarcadores y un estudio molecular en 81 biopsias de cáncer de cuello uterino (59 carcinomas epidermoides y 19 adenocarcinomas cervicales) diagnosticados en el Servicio de Anatomía Patológica del Hospital Clínico Universitario de Valencia, con la finalidad de realizar la caracterización inmunohistoquímica de esta neoplasia invasora y determinar la presencia de ADN-HPV asociado. El estudio inmunohistoquímico se realizó, en tumores cervicales y tejido cervical benigno como control, mediante la técnica de avidina-biotina, interpretado mediante una escala semicuantitativa. Se determinó la presencia y genotipificación de A…
Plazmas vienādojuma analīze
2017
Darbā tiek apskatīta trīs dimensiju autonomu parasto diferenciālvienādojumu sistēmu, kas modelē plazmas dinamiku. Īsi aprakstīts tās izvedums, tās galvenās īpašības un, izmantojot skaitliskas un kvalitatīvas metodes, tiek pētīta stacionāro punktu lokālā un globālā stabilitāte, kā arī bifurkācijas, kas rodas pie konkrētiem parametriem. Pētījumā izmantota Ļapunova tipa funkcija un centra varietātes teorēma.
Tenascin gene expression in rat liver and in rat liver cells. In vivo and in vitro studies.
1991
Tenascin is a major glycoprotein constituent of the extracellular matrix with a strong affinity to fibronectin; its distribution is believed to be temporarily and spatially limited. Tenascin gene expression is increased during wound healing processes. As repair mechanisms in chronic liver diseases resemble wound healing we studied tenascin gene expression in rat liver and in isolated rat liver cells. In normal rat liver a tenascin specific antiserum stains sinusoidal cells with fiber-like prolongations, which at the same time are desmin-positive (ITO-cells). In the CCl4-acutely-damaged liver a strong tenascin staining is detected in cells located among the mononuclear cells of the inflammat…
Diversity, Complexity and Ordinality: Mental Health Services Outside the Institutions—Service Users’ and Professionals’ Experience-Based Practices an…
2021
In conjunction with the dismantling of psychiatric hospitals, social workers have been commissioned to help service users in their daily living in their homes and in the community. The consequences of these changes for experience-based knowledge and practices in their contexts remain relatively unknown. In this study, eighteen service users and the social workers they described as helpful for them were interviewed. The interviews were recorded, transcribed, and analyzed using Thematic Analysis. The following themes emerged: “Here, there and everywhere”, “Doing, being, becoming”, “Talking” and “Order, planning and improvisation” concerning the contradictions service users and professionals m…
Less Effort, Better Results: How Does Music Act on Prefrontal Cortex in Older Adults during Verbal Encoding? An fNIRS Study
2014
Several neuroimaging studies of cognitive aging revealed deficits in episodic memory abilities as a result of prefrontal cortex (PFC) limitations. Improving episodic memory performance despite PFC deficits is thus a critical issue in aging research. Listening to music stimulates cognitive performance in several non-purely musical activities (e.g., language and memory). Thus, music could represent a rich and helpful source during verbal encoding and therefore help subsequent retrieval. Furthermore, such benefit could be reflected in less demand of PFC, which is known to be crucial for encoding processes. This study aimed to investigate whether music may improve episodic memory in older adult…