Search results for "Phenolic"

showing 10 items of 200 documents

Risk factors and interventional strategies for BK polyomavirus infection after renal transplantation.

2012

BK virus (BKV)-induced viraemia after renal transplantation can be associated with severe impairment of graft function. This study evaluated possible risk factors for BKV replication and examined the outcomes following various currently used treatment approaches.Fifty-seven renal transplant recipients with BKV viraemia were retrospectively compared with 71 BKV-negative recipients to identify risk factors for BKV viraemia. Furthermore, outcome and graft function in 14 patients with BKV replication, in whom mycophenolate mofetil (MMF) was discontinued with a dose reduction of the remaining immunosuppressants, were compared with 32 patients in whom both MMF and the additional immunosuppressant…

NephrologyAdultMalemedicine.medical_specialtyvirusesUrologyLymphocytemedicine.medical_treatmentPrednisoloneAnti-Inflammatory AgentsKaplan-Meier Estimatemedicine.disease_causeVirus ReplicationGastroenterologyTacrolimusRisk FactorsInternal medicineConfidence IntervalsOdds RatioMedicineHumansLymphocyte CountWarm IschemiaRetrospective StudiesPolyomavirus Infectionsbusiness.industryGraft Survivalvirus diseasesImmunosuppressionOdds ratioMiddle AgedMycophenolic AcidViral LoadKidney TransplantationTacrolimusBK virusTransplantationTumor Virus Infectionsmedicine.anatomical_structureNephrologyBK VirusImmunologyCyclosporineDrug Therapy CombinationFemalebusinessViral loadImmunosuppressive AgentsScandinavian journal of urology and nephrology
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Total Nut, Tree Nut, and Peanut Consumption and Metabolic Status in Southern Italian Adults.

2021

Background: Nut consumption has been associated with cardio-metabolic health benefits. However, studies conducted in the Southern Italian population, where adherence to the Mediterranean diet has been reported being relatively high, are rather scarce. The aim of this study was to test the association between consumption of total and specific types of nuts and metabolic status among adults living in Sicily, Southern Italy. Methods: Demographic and dietary characteristics of 2044 adults living in Southern Italy were analyzed. Multivariate logistic regression analyses were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) of the association between nut consumption and…

NutPolyphenolAdulthypertensionMediterranean dietArachis030309 nutrition & dieteticsHealth Toxicology and Mutagenesislcsh:Medicine030209 endocrinology & metabolismType 2 diabetestype-2 diabetesAlmondLogistic regressionArticle03 medical and health sciences0302 clinical medicineMediterranean dietmedicineHumansNutsSettore MED/49 - Scienze Tecniche Dietetiche ApplicateSicilypolyphenols0303 health sciencesPhenolic acidbusiness.industryConfoundinglcsh:RdyslipidemiaPublic Health Environmental and Occupational HealthalmondsOdds ratiocohortmedicine.diseasetree nutDietDiabetes Mellitus Type 2CohortpeanutType-2 diabetes.businessphenolic acidsDyslipidemiaDemographyInternational journal of environmental research and public health
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EVOLUZIONE DELLA COMPONENTE FENOLICA E DELL'ATTIVITA ANTIOSSIDANTE NEI SUCCHI DI DIVERSI GENOTIPI DI ARANCIO DURANTE LA MATURAZIONE.

2009

ORANGE JUICE PHENOLIC COMPOUNDS ANTIOXIDANT ACTIVITY
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Macroalgal responses to ocean acidification depend on nutrient and light levels

2015

Ocean acidification may benefit algae that are able to capitalize on increased carbon availability for photosynthesis, but it is expected to have adverse effects on calcified algae through dissolution. Shifts in dominance between primary producers will have knock-on effects on marine ecosystems and will likely vary regionally, depending on factors such as irradiance (light vs. shade) and nutrient levels (oligotrophic vs. eutrophic). Thus experiments are needed to evaluate interactive effects of combined stressors in the field. In this study, we investigated the physiological responses of macroalgae near a CO2 seep in oligotrophic waters off Vulcano (Italy). The algae were incubated in situ …

Ocean Acidification International Coordination Centre (OA-ICC)TemperateSalinityChlorophyll aFucoxanthininorganicAlkalinityPhotosynthetic efficiency standard errorChlorophyll cNitrogen content per dry mass standard errorLight saturation point standard errorPhenolics allTemperature waterCarbon inorganic dissolvedMacroalgaeCalculated using seacarb after Nisumaa et al 2010Carbon Nitrogen ratioAragonite saturation stateAlkalinity totalallCarbon per dry massSalinity standard errortotalCarbon content per dry mass standard errorPhenolics all standard errorCO2 ventChromistapHMaximum photochemical quantum yield of photosystem II standard errorTemperaturePartial pressure of carbon dioxide (water) at sea surface temperature (wet air) standard errordissolvedAntioxidant activity standard errorCarbonate ionMaximum photochemical quantum yield of photosystem IIPartial pressure of carbon dioxide (water) at sea surface temperature (wet air)Field experimentstandard errorNitrogen content per dry massElectron transport rate standard errorFucoxanthin standard errorEarth System ResearchViolaxanthinPhenolicsChlorophyll a standard errorCarbon dioxide standard errorPotentiometric titrationCalcite saturation stateCarbon/Nitrogen ratio standard errorNitrogenOchrophytaPotentiometricper dry masswaterChlorophyll c standard errorBenthosAlkalinity total standard errorAntioxidant activityElectron transport rateLight saturation pointOcean Acidification International Coordination Centre OA ICCMacro-nutrientsMediterranean SeaNitrogen per dry massBicarbonate ionTemperature water standard errorCalculated using seacarb after Nisumaa et al. (2010)Primary production PhotosynthesisSpeciespH standard errorCalcite saturation state standard errorCystoseira compressaCalculated using CO2SYSNon photochemical quenchingCarbon content per dry massCarbonate system computation flagViolaxanthin standard errorPrimary production/PhotosynthesisFugacity of carbon dioxide (water) at sea surface temperature (wet air)CarbonCarbon/Nitrogen ratioBiomass/Abundance/Elemental compositionTreatmentPartial pressure of carbon dioxide water at sea surface temperature wet airAragonite saturation state standard errorCarbon dioxideMacro nutrientsCarbonate ion standard errorSingle speciesFugacity of carbon dioxide water at sea surface temperature wet airPadina pavonicaBiomass Abundance Elemental compositionCoast and continental shelfPhotosynthetic efficiencyBicarbonate ion standard errorNon photochemical quenching standard error
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Phenolic profiles of olive mill wastewaters treated by membrane filtration systems

2014

BACKGROUND Olive mill wastewater is an important by-product obtained after olive oil extraction. In this investigation, the phenolic composition of olive mill wastewater treated with a semi-industrial membrane filtration system, including ultrafiltration and reverse osmosis modules, was studied. In particular, untreated olive mill wastewater was compared with the permeate and the concentrate fractions of each filtration step. RESULTS 3,4-(dihydroxyphenyl) ethanol and p-(hydroxyphenyl) ethanol were the main compounds of all olive mill wastewater analyzed. A total of 32 compounds, detected at 240 or 280 nm by HPLC-DAD, were considered for phenol quantification. Ultrafiltration reduced phenol …

Olive mill wastewaterChromatographyEthanolPhenolic compoundRenewable Energy Sustainability and the EnvironmentGeneral Chemical EngineeringOrganic ChemistryUltrafiltrationPermeationPollutionReverse osmosiInorganic Chemistrychemistry.chemical_compoundMembraneFuel TechnologychemistryWastewaterOlive oil extractionPhenolChemical Engineering (all)PhenolsReverse osmosisWaste Management and DisposalBiotechnology
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Treatment of pemphigus vulgaris with mycophenolate mofetil

1997

different pattern of diffusion changes in a 51-year-old woman with chronic epilepsy and recurrent episodes of focal status epilepticus, for whom no aetiology could be established. Status consisted of clonic jerking of the right leg, which continued for 22 days and was followed by transient paresis. DWI during status showed decreased diffusion in the motor cortex of the right leg (relative decrease in ADC of 27%, see figure). Surprisingly, the diffusion was increased in the subcortical white matter (relative increase in ADC of 31%). On the T2-weighted image (not shown), both cortex and subcortical white matter of the corresponding region returned a high signal similar to previously reported …

Pathologymedicine.medical_specialtyPrednisoloneAnti-Inflammatory AgentsMycophenolateMycophenolic acidWhite matterIMP DehydrogenaseCortex (anatomy)medicineHumansPremovement neuronal activityParesisbusiness.industryRemission InductionPemphigus vulgarisGeneral MedicineMycophenolic Acidmedicine.diseasemedicine.anatomical_structureDrug Therapy Combinationmedicine.symptombusinessImmunosuppressive AgentsPemphigusmedicine.drugMotor cortexThe Lancet
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Phenolic compounds of herbal infusions obtained from some species of the Lamiaceae family

2018

Abstract The present investigation was to estimate the total phenolic content and composition of flavonoids and hydroxycinnamic acids in herbal infusions obtained from aerial parts of three Lamiaceae species (Dracocephalum moldavica, Ocimum americanum and Satureja hortensis). The total phenolic content of herbal infusions was determined using a spectrophotometric method, whereas the individual phenolics were assessed by high-performance liquid chromatography (HPLC). The HPLC method was developed and validated. The total phenolic content was measured by applying the Folin-Ciocalteu method with reference to gallic acid. Results were in the range from 29.39 to 65.38 mg estimated as gallic acid…

Pharmacology toxicologyPharmacyphenolic compounds01 natural sciencesBiochemistryOcimum americanumspectrophotometryMedicineDracocephalum moldavicaMolecular BiologyPharmacologyTraditional medicinebiologySatureja hortensis010405 organic chemistrybusiness.industry010401 analytical chemistryRfood and beveragesGeneral Medicinebiology.organism_classification0104 chemical sciencesMedicineLamiaceaeHPLCbusinessCurrent Issues in Pharmacy and Medical Sciences
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CYP3A5*3 and CYP2C8*3 variants influence exposure and clinical outcomes of tacrolimus-based therapy

2020

Aim: The influence of variants in pharmacokinetics-related genes on long-term exposure to tacrolimus (TAC)-based therapy and clinical outcomes was investigated. Patients & methods: Brazilian kidney recipients were treated with TAC combined with everolimus (n = 178) or mycophenolate sodium (n = 97). The variants in CYP2C8, CYP2J2, CYP3A4, CYP3A5, POR, ABCB1, ABCC2, ABCG2, SLCO1B1 and SLCO2B1 were analyzed. Main results: CYP3A5*3/*3 genotype influenced increase in TAC concentration from week 1 to month 6 post-transplantation (p < 0.05). The living donor and CYP2C8*3 variant were associated with reduced risk for delayed graft function (OR = 0.07; 95% CI = 0.03–0.18 and OR = 0.45; 95% C…

PharmacologyKidneymedicine.medical_specialtyEverolimusbiologybusiness.industryGastroenterologyTacrolimusMycophenolic acidmedicine.anatomical_structurePharmacokineticsInternal medicineGeneticsmedicinebiology.proteinFARMACOCINÉTICAMolecular MedicineSLCO1B1CYP3A5businessCYP2C8medicine.drug
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2015

BACKGROUND Expensive pharmaceuticals are a major reason for cost intensive health care systems. Long-term immunosuppressive therapy plays a relevant role after organ transplantation. Patents of original drugs have expired and cheaper products are available. Little data are available regarding efficacy and safety of generic immunosuppressive agents. METHODS In this prospective study, 25 patients, who were clinically stable for a minimum of 2 years after liver transplantation, were converted from the original formulations of tacrolimus (TAC) and mycophenolate mofetil to the generics Tacpan (TAP) and Mowel (MOW). Patients were followed-up for 6 months. Results were compared retrospectively to …

PharmacologyPathologymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentPharmaceutical ScienceImmunosuppressionLiver transplantationMycophenolateTacrolimusMycophenolic acidOrgan transplantationInternal medicineDrug DiscoverymedicineTrough levelProspective cohort studybusinessmedicine.drugDrug Design, Development and Therapy
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Cytotoxic properties of Marrubium globosum ssp. libanoticum and its bioactive components

2013

Marrubium globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae) is a medicinal plant used in Lebanon for the treatment of inflammatory diseases, asthma, coughs and other pulmonary and urinary problems. The goal of our study was to assess the biological activity of M. globosum by testing different extracts of the aerial parts for their antiproliferative activity against human melanoma cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The chloroform fraction showed the greatest activity. The compounds isolated from the extracts were also tested: the mixture of (13 S)-9α,13α-epoxylabda-6β(19),16(15)-diol dilactone and (13 R)-9α,13α-epo…

PharmacologybiologyTraditional medicineChemistryCytotoxicityPlant ScienceGeneral MedicineSettore CHIM/06 - Chimica OrganicaMarrubium globosum Lebanon antiproliferative activitybiology.organism_classificationLabdane diterpenoidPhenolic compoundsComplementary and alternative medicineDrug DiscoveryMarrubium globosum libanoticumCytotoxic T cellSettore BIO/15 - Biologia FarmaceuticaMelanomaMarrubium
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