Search results for "Pie"
showing 10 items of 4404 documents
Cmentarz Sapieżyński w Stanisławowie
2021
This article presents the history of one of the largest Polish cemeteries in the Eastern Borderlands. Thousands of Poles, including artists, poets, writers, sculptors, prominent politicians, local government officials and soldiers fighting for Polish independence in various uprisings, were buried in the Sapieżyński Cemetery during its 200-year-long history. The necropolis was closed down by the Soviet authorities in 1980, and the entire area was bulldozed. Crushed tombstones were transported outside the city, and a theater building and a hotel were developed on the site. The paper recreates the cemetery’s history and tells the life stories of the most prominent individuals who were laid to …
A method to enable the investigation of murine bronchial immune cells, their cytokines and mediators.
2007
Innovative therapies for severe lung diseases (such as allergic and chronic asthma, chronic obstructive pulmonary disease or any type of lung cancer) require a detailed understanding of the cellular and immune processes in the lung. This protocol details a method to obtain the immune cells of the bronchi as well as the cytokines and mediators produced by these cells for further investigation. The broncho-alveolar lavage fluid (BALF) is taken by injecting physiological solution through the tracheal tube into the murine airways and carefully regained by winding up the connected syringe. After centrifugation, the resulting BALF supernatant can be stored for detection of cytokines or other medi…
PLASTICITA CEREBRALE
2007
Data Compression Approach for Long-Term Monitoring of Pavement Structures
2019
Pavement structures are designed to withstand continuous damage during their design life. Damage starts as soon as the pavement is open to traffic and increases with time. If maintenance activities are not considered in the initial design or considered but not applied during the service life, damage will grow to a point where rehabilitation may be the only and most expensive option left. In order to monitor the evolution of damage and its severity in pavement structures, a novel data compression approach based on cumulative measurements from a piezoelectric sensor is presented in this paper. Specifically, the piezoelectric sensor uses a thin film of polyvinylidene fluoride to sense the ener…
Pacientu pieredze COVID – 19 nodaļā un tās ietekme uz sociālo interakciju un psihoemocionālo labsajūtu pēc hospitalizācijas
2022
Maģistra darba tēma “Pacientu pieredze COVID – 19 nodaļā un tās ietekme uz sociālo interakciju un psihoemocionālo labsajūtu pēc hospitalizācijas”. Psihiskā veselība ir nozīmīga un neatņemama vispārējās veselības komponente. Laba indivīda un kopējā sabiedrības psihiskā veselība ir būtisks nosacījums stabilas, drošas un labklājīgas sabiedrības veidošanai. (10). Darba mērķis ir noskaidrot pacientu pieredzi COVID – 19 un tās ietekmi uz sociālo interakciju un psihoemocionālo labsajūtu pēc hospitalizācijas. Vadoties pēc izvirzītā mērķa, tā sasniegšanai maģistra darbā tika risināti šādi uzdevumi: izanalizēt un apkopot literatūras avotus par dzīves kvalitāti, par psihoemocionālo labsajūtu, sociālo …
Vaccinium spp. ogu izspiedu ekstraktu pretiekaisuma īpašības
2020
Ilgstošs iekaisums ir būtisks faktors hronisku slimību attīstībā, taču vēl joprojām nav pieejami pilnībā droši pretiekaisuma līdzekļi, tādēļ pasaulē pieaug interese par dabīgas izcelsmes savienojumiem ar pretiekaisuma īpašībām. Vaccinium ģints ogas pazīstamas ar augstu bioloģisko aktivitāti un labvēlīgu ietekmi uz cilvēku veselību, pateicoties augstam polifenolu saturam. Šobrīd ogu izspiedas tiek pētītas kā alternatīvs fitoķīmisko savienojumu avots ar veselību veicinošu potenciālu. Darba mērķis ir izpētīt piecu Vaccinium spp. ogu izspiedu ekstraktu pretiekaisuma īpašības, izmantojot lipoksigenāzes (5-LOX), ciklooksigenāzes (COX-1) un ksantīna oksidāzes inhibitoru skrīninga testus. Melleņu, …
Energy compensation and adiposity in humans
2021
Publisher Copyright: © 2021 The Authors Understanding the impacts of activity on energy balance is crucial. Increasing levels of activity may bring diminishing returns in energy expenditure because of compensatory responses in non-activity energy expenditures.1–3 This suggestion has profound implications for both the evolution of metabolism and human health. It implies that a long-term increase in activity does not directly translate into an increase in total energy expenditure (TEE) because other components of TEE may decrease in response—energy compensation. We used the largest dataset compiled on adult TEE and basal energy expenditure (BEE) (n = 1,754) of people living normal lives to fi…
Determination of essential biomarkers in lung cancer: a real-world data study in Spain with demographic, clinical, epidemiological and pathological c…
2022
Abstract Background The survival of patients with lung cancer has substantially increased in the last decade by about 15%. This increase is, basically, due to targeted therapies available for advanced stages and the emergence of immunotherapy itself. This work aims to study the situation of biomarker testing in Spain. Patients and methods The Thoracic Tumours Registry (TTR) is an observational, prospective, registry-based study that included patients diagnosed with lung cancer and other thoracic tumours, from September 2016 to 2020. This TTR study was sponsored by the Spanish Lung Cancer Group (GECP) Foundation, an independent, scientific, multidisciplinary oncology society that coordinates…
MEF2C and SOCS2 in stemness regulation
2015
The physiologic stemness of hematopoietic stem cells (HSC) relies on mechanisms constitutively active under steady state and is fundamental to maintain a lifelong HSC reservoir. On the other side, similar stemness features sustained by partially overlapping molecular circuits, which have recently come into focus, confer aggressive aggressiveness in leukemia clones. Suppressor of Cytokine Signalling 2 (SOCS2) belongs to the SOCS family, comprising eight members (SOCS1–7 and CIS) with similar structures, which are induced upon JAK/STAT activation and function as negative regulators. Recent evidences have demonstrated that SOCS2 is endowed with immunological functions in differentiated cells b…
Management of orphan symptoms: ESMO Clinical Practice Guidelines for diagnosis and treatment†
2020
### Highlights There is no clear definition of orphan symptoms. There is a group of symptoms that are seldom evaluated in most symptom assessment tools which can be considered as orphan symptoms.1 These are generally prevalent symptoms that are unaddressed in clinical practice, yet often not reported by the patients or by healthcare professionals.2 Orphan symptoms may be defined as symptoms not regularly assessed in clinical practice, and consequently little studied and not properly treated. No epidemiological or clinical studies generally exist to gauge the prevalence of the symptoms chosen; nevertheless, these symptoms are distressing for patients and their families. Orphan symptoms remai…