Search results for "Pike"
showing 10 items of 130 documents
Effects of paper mill effluents on the fish fauna of stony shores of Lake Päijänne
1992
The fish fauna of the stony littoral in the central parts of L. Paijanne was studied by electric fishing on four occasions during 1988–1989. Ten fish species and 1681 individuals (14.5 kg) were caught in the 15 fishing sites (4096 m2) which gives a mean density of 0.41 ind. m-2 and biomass of 3.5 g m-2. Effluent from two large paper mills causes a clear zonation of the fish fauna in the area. In the most polluted shores, only burbot and perch occurred regularly and the reproduction of other species was inhibited. In the semipolluted area (5–15 km from the Kaipola paper mill), burbot and stone loach occurred regularly, but owing to low numbers of perch and bullhead the total densities were u…
Interfering with Host Proteases in SARS-CoV-2 Entry as a Promising Therapeutic Strategy
2020
Abstract: Due to its fast international spread and substantial mortality, the coronavirus disease COVID-19 evolved to a global threat. Since there is currently no causative drug against this viral infection available, science is striving for new drugs and other approaches to treat the new disease. Studies have shown that the cell entry of coronaviruses into host cells takes place through the binding of the viral spike (S) protein to cell receptors. Priming of the S protein occurs via hydrolysis by different host proteases. The inhibition of these proteases could impair the processing of the S protein, thereby affecting the interaction with the host-cell receptors and preventing virus cell …
Blackfly Larvae (Simulium spp.) Can Intensify Methylmercury Biomagnification in Boreal Food Webs
2020
AbstractGlobal pollution of mercury (Hg) threatens ecosystem and human health. We measured total Hg (THg) and monomethylmercury (MMHg) concentrations in filter-feeding blackfly (Simulium spp.) larvae in the inflows and the outflows of six boreal lakes with no Hg point source pollution. THg in the larvae ranged from 0.03 to 0.31 mg kg−1 dw and MMHg between 0.02 and 0.25 mg kg−1 dw. The proportion of MMHg in the larvae was 74 ± 0.16% and ranged from 43 to 98% of THg, the highest proportions being comparable to those typically found in aquatic predatory insects and fish. We compared the larvae MMHg concentrations to river water quality, catchment land-use, and to size-adjusted lake pike THg da…
Between-population Similarity in Intestinal Parasite Community Structure of Pike (Esox Lucius)—Effects of Distance and Historical Connections
2009
The effect of geographical distance on similarity in parasite communities of freshwater fish has received considerable attention in recent years, and it has become evident that these apparently simple relationships are influenced by, among other things, colonization ability of parasites and degree of connectivity between the populations. In the present paper, we explored qualitative and quantitative similarity in the intestinal parasite communities of pike (Esox lucius) in a particular system where previously interconnected groups of lakes became isolated ca. 8,400 yr ago. Contrary to our expectations, we did not find differences in similarity between the lake groups or a negative effect of…
An unexpected biomaterial against SARS-CoV-2: Bio-polyphosphate blocks binding of the viral spike to the cell receptor.
2021
Graphical abstract
A potential solution to avoid overdose of mixed drugs in the event of Covid-19: Nanomedicine at the heart of the Covid-19 pandemic.
2021
Since 2020, the world is facing the first global pandemic of 21st century. Among all the solutions proposed to treat this new strain of coronavirus, named SARS-CoV-2, the vaccine seems a promising way but the delays are too long to be implemented quickly. In the emergency, a dual therapy has shown its effectiveness but has also provoked a set of debates around the dangerousness of a particular molecule, hydroxychloroquine. In particular, the doses to be delivered, according to the studies, were well beyond the acceptable doses to support the treatment without side effects. We propose here to use all the advantages of nanovectorization to address this question of concentration. Using quantum…
Targeting SARS-CoV-2 RBD Interface: a Supervised Computational Data-Driven Approach to Identify Potential Modulators
2020
Coronavirus disease 2019 (COVID-19) has spread out as a pandemic threat affecting over 2 million people. The infectious process initiates via binding of SARS-CoV-2 Spike (S) glycoprotein to host angiotensin-converting enzyme 2 (ACE2). The interaction is mediated by the receptor-binding domain (RBD) of S glycoprotein, promoting host receptor recognition and binding to ACE2 peptidase domain (PD), thus representing a promising target for therapeutic intervention. Herein, we present a computational study aimed at identifying small molecules potentially able to target RBD. Although targeting PPI remains a challenge in drug discovery, our investigation highlights that interaction between SARS-CoV…
Insights in ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopenia
2021
Abstract SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we identified determinants of this vaccine-induced adverse reaction. Super-resolution microscopy visualized vaccine components forming antigenic complexes with platelet factor 4 (PF4) on platelet surfaces to which anti-PF4 antibodies obtained from VITT patients bound. PF4/vaccine complex formation was charge-driven and increased by addition of DNA. Proteomics identified substantial amounts of virus production-derived T-REx HEK293 proteins in the ethyle…
Bioaccumulation of dioxins, coplanar PCBs, PCDEs, HxCNs, R-PCNs, R-PCPHs and R-PCBBs in fish from a pulp-mill recipient watercourse
1993
Abstract Pike, perch and lake bream from the river Kymijoki were analyzed by gas chromatography/mass spectrometry (GC/MS) for toxic polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), hexachlorinated naphthalenes (HxCNs), non-ortho substituted polychlorinated biphenyls (coplanar PCBs) and alkylchloroaromatics of pulp mill origin. In most fish, the only congener of PCDD/PCDFs found was 2,3,7,8-TeCDF (
An Application of Spike-Timing-Dependent Plasticity to Readout Circuit for Liquid State Machine
2007
Liquid state machine (LSM) is a neural system based on spiking neurons that implements a mapping between functions of time. A typical application of LSM is classification of time functions obtained observing the state of the liquid by using a memoryless readout circuit, usually implemented by a linear perceptron. Due to the high number of neurons in the liquid the training of the readout is difficult. In this paper we show that using the Spike-Timing-Dependent Plasticity (STDP) a single neuron with short training session can be used to recognize the state of the liquid due to an input signal. Using STDP it is possible to identify the spikes timing of the neurons in the liquid and this allow…