Search results for "Plate"
showing 10 items of 1689 documents
Lipid-Mediated Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample
2018
Abstract Background: Tissue factor pathway inhibitor (TFPI), a Kunitz-type serine protease, is a potent anticoagulant protein in the extrinsic coagulation pathway and acts by inhibiting both the FXa and the Tissue Factor-FVIIa complex. In contrast to total and free TFPI antigen levels, the reference values and clinical determinants of total TFPI activity have not yet been studied in detail in the general population. In the present study, we aim to identify the cardiovascular determinants for total TFPI activity and investigate its association with cardiovascular disease (CVD) and total mortality, in a population at large. Methods: For this study, the first 4779 subjects of the population-ba…
TYPE II DIABETES MELLITUS HAS NO MAJOR INFLUENCE ON PLATELET MICRO–RNA EXPRESSION: RESULTS FROM MICRO–ARRAY PROFILING IN A COHORT OF 60 PATIENTS
2013
Blood platelets represent pro–inflammatory mediators in the development of atherosclerosis. Diabetes mellitus as a major contributor to cardiovascular disease burden induces dysfunctional platelets. Platelets contain abundant miRNAs, which recently have been linked tightly to inflammation. While
Investigation of buckling characteristics of cracked variable stiffness composite plates by an eXtended Ritz approach
2021
Abstract Variable Angle Tow (VAT) composite plates are characterized by in-plane variable stiffness properties, which opens to new concepts of stiffness tailoring and optimization to achieve higher structural performance for advanced lightweight structures where damage tolerance consideration are often mandatory. In this paper, a single-domain eXtended Ritz formulation is proposed to study the buckling behaviour of variable stiffness laminated cracked plates. The plate behaviour is described by the first order shear deformation theory whose generalized displacements, namely reference plane translations and rotations, are expressed via suitable admissible trial functions. These consist of a …
Generation of an Eosinophilotactic Factor from Human PMNs by Various Mechanisms of Cell Activation
1979
It is well established that an increase in the number of eosinophils both in tissue and in the circulation is a feature of many clinical conditions based on delayed (1,2) and immediate type hypersensitivity reactions (3,4). Since eosinophils have been recognised to exert specific killer function on parasites (5) and to be prominent participants at sites of inflammation, the mechanisms of their chemo-attraction are of major importance. In immediate type hypersensitivity reactions, eosinophils have been demonstrated to counteract the mediators of inflammation such as histamine (6), the SRS-A (7) and the platelet aggregating factor (8).
Bone Healing with or without Platelet-Rich Plasma around Four Different Dental Implant Surfaces in Beagle Dogs
2013
Purpose Surface development is one of the major aims in dental implant engineering. Additive application of substances could possibly improve the new bone formation around dental implants. The present study evaluated the bone reaction on four different implant surfaces with or without platelet-rich plasma (PRP). Materials and Methods Four self-tapping titanium screw implants (Branemark MK III [Nobel Biocare, Goteborg, Sweden], Osseotite [3i, Miami, FL, USA], Xive [Densply Friadent, Mannheim, Germany], and Compress [IGfZ eG, Diez, Germany]) with different surfaces were inserted in each hemimandible of 12 female beagle dogs; the implant positions and the application of PRP were randomized. Af…
Abciximab Facilitates the Rate and Extent of Thrombolysis
1999
Background —The TIMI 14 trial tested the hypothesis that abciximab, the Fab fragment of a monoclonal antibody directed to the platelet glycoprotein (GP) IIb/IIIa receptor, is a potent and safe addition to reduced-dose thrombolytic regimens for ST-segment elevation MI. Methods and Results —Patients (n=888) with ST-elevation MI presenting <12 hours from onset of symptoms were treated with aspirin and randomized initially to either 100 mg of accelerated-dose alteplase (control) or abciximab (bolus 0.25 mg/kg and 12-hour infusion of 0.125 μg · kg −1 · min −1 ) alone or in combination with reduced doses of alteplase (20 to 65 mg) or streptokinase (500 000 U to 1.5 MU). Control patients recei…
Role of genetic polymorphisms in myocardial infarction at young age
2010
Acute myocardial infarction (AMI) in young adult presents a typical pattern of risk factors, clinical, angiographic and prognostic characteristics. In the last years we demonstrated that hemorheological profile is altered in these patients in a persistent way and independently of the number of risk factors and of the extent of coronary lesions. Thus, the hyperviscosity syndrome following AMI could be considered an intrinsic characteristic of these patients. Consequently it is possible to hypothesise the presence of a genetic background at the origin of this predisposition. If this background is able to influence the risk of ischemic heart disease, this should be particularly evident in youn…
Water-compatible molecularly imprinted polymers obtained via high-throughput synthesis and experimental design.
2003
A technique allowing high-throughput synthesis and evaluation of molecularly imprinted polymer sorbents at a reduced scale (mini-MIPs) was developed and used for the optimization of MIPs for use in pure aqueous environments. The technique incorporated a 4-port liquid-handling robot for the rapid dispensing of monomers, templates, solvents and initiator into the reaction vessels of a 96-well plate. A library of 80 polymers, each ca. 50 mg, could thus be prepared in 24 h. The MIP rebinding capacity and selectivity could be rapidly assessed in the batch mode by quantifying nonbound fractions in parallel using a UV monochromator plate reader. This allowed a complete evaluation of the binding ch…
Different metabolic behavior of long-chain n-3 polyunsaturated fatty acids in human platelets.
1988
Abstract Whereas numerous studies deal with the effects and metabolism of eicosapentaenoic acid (20:5( n −3)) in platelets, very few concern docosahexaenoic acid (22:6( n −3)), although both acids are consumed in equal amounts from most fish fat. The present paper reports the modulation of 22:6( n −3) oxygenation as well as that of endogenous arachidonic acid (20:4( n −6)) in 22:6( n −3)-rich platelets. Like the oxygenation of 20:5( n −3), the lipoxygenation of 22:6( n −3) occurred at a low level when incubated alone, but was markedly increased in the presence of 20:4( n −6), suggesting a similar peroxide tone dependency. 20:5( n −3) could not replace 20:4( n −6) in the increasing 22:6( n −…
Life-time studies with capillary electrochromatography columns operated under different conditions.
2000
A test system has been established to permit the monitoring of the life-time performance of several reversed- phase capillary electrochromatography (CEC) columns. The retention factors, k(cec), peak symmetry coefficients, lambda(sym), and column efficiencies, N, of three neutral n-alkylbenzene analytes, namely ethyl-, n-butyl- and n-pentylbenzenes, were determined for Hypersil 3 microm n-octylsilica and n-octadecylsilica packed into CEC capillary columns of 100 microm I.D., with a packed length of 250 mm, and a total length of 335 mm. The performances of these CEC capillary columns were examined for a variety of eluents with pH values ranging between pH 2.0 - 8.0, similar to those employed …