Search results for "Polar"

Molecular Network Establishing Dorsal-Ventral polarity during sea urchin embryogenesis

2015

Enhancing Light Emission in Interface Engineered Spin-OLEDs through Spin-Polarized Injection at High Voltages

2019

The quest for a spin-polarized organic light-emitting diode (spin-OLED) is a common goal in the emerging fields of molecular electronics and spintronics. In this device, two ferromagnetic (FM) electrodes are used to enhance the electroluminescence intensity of the OLED through a magnetic control of the spin polarization of the injected carriers. The major difficulty is that the driving voltage of an OLED device exceeds a few volts, while spin injection in organic materials is only efficient at low voltages. The fabrication of a spin-OLED that uses a conjugated polymer as bipolar spin collector layer and ferromagnetic electrodes is reported here. Through a careful engineering of the organic/…

Effect of molecular Stokes shift on polariton dynamics

2021

When the enhanced electromagnetic field of a confined light mode interacts with photoactive molecules, the system can be driven into the regime of strong coupling, where new hybrid light–matter states, polaritons, are formed. Polaritons, manifested by the Rabi split in the dispersion, have shown potential for controlling the chemistry of the coupled molecules. Here, we show by angle-resolved steady-state experiments accompanied by multi-scale molecular dynamics simulations that the molecular Stokes shift plays a significant role in the relaxation of polaritons formed by organic molecules embedded in a polymer matrix within metallic Fabry–Pérot cavities. Our results suggest that in the case …

Comparison of decision variants with reference set (BIPOLAR method) in selection process of suppliers

2018

Bipolar is one of the Multiple Criteria Decision Analysis (MCDA) methods, proposed by Ewa Konarzewska-Gubała [6, 7, 8]. The essence of the analysis in the BIPOLAR method consists in a fact that alternatives are not compared directly to each other, but they are confronted to the two sets of reference objects: good and bad. Some alternatives can be evaluated as over good, i.e. better than at least one of desirable reference object or underbid, i.e. worse than at least of one nonacceptable object. Proposed method takes into account all stages of the decision-making process, starting with the selection of criteria and determining their weights, by modelling the preferences of decision-makers, o…

A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26.

2000

In an attempt to identify susceptibility loci for bipolar affective disorder, we are currently conducting a systematic genome screen with highly polymorphic microsatellite markers at an average marker spacing of 10 cM in a series of 75 families, comprising 66 families from Germany, eight families from Israel, and one family from Italy. The families were ascertained through index cases with bipolar affective disorder. The distribution of diagnoses is as follows: 126 individuals with bipolar I disorder, 40 with bipolar II disorder, 14 with schizoaffective disorder of the bipolar type, 40 individuals with recurrent unipolar depression, 51 with a minor psychiatric diagnosis, and two individuals…

Endocannabinoid Role in Synaptic Plasticity and Learning

2009

Endocannabinoids have recently emerged as versatile modulators of synaptic transmission and can act as retrograde neurotransmitters. As they cannot be stored in synaptic vesicles, endocannabinoid signaling is believed to start ‘on-demand,’ via a stimulus-dependent synthesis from membranous precursors at the postsynaptic site. After synthesis, endocannabinoids bind presynaptically to cannabinoid type 1 (CB1) receptors, leading to a short- or long-term suppression of neurotransmitter release. CB1 receptors are present in a plethora of different synaptic connections in the brain. Electrophysiological and behavioral analyses of mutant mice lacking CB1 receptors and of pharmacologically treated …

Etude en champ proche et en champ lointain de composants périodiquement nanostructurés : cristaux photoniques et tamis à photons

2004

Recently, a new class of optical components is appeared. Its main characteristic is to be formed by a periodical sub-wavelength pattern, leading to the apparition of a spectral domain where propagation of light inside the structure is forbidden -- a photonic bandgap. This work is devoted to the study in the near- and far-field of two kinds of periodical optical components: photonic crystals (PCs) and nanostructured metallic films that exhibit the so-called enhanced transmission. First, we study two-dimensional PCs with a scanning near-field optical microscope (SNOM) in collection mode. With this SNOM, we directly map the intensity distribution inside PC-based microcavities. We also evidence…

Acción del sugamadex y de los bloqueantes neromusculares: rocuronio y vecuronio en neuronas en cultivo primario

2017

INTRODUCCIÓN: El ROCURONIO y VECURONIO son los relajantes musculares no despolarizantes BNMNP más usados en la práctica clínica. El SUGAMADEX es el fármaco utilizado como reversor de la relajación muscular producida por los bloqueantes neuromusculares citados. En el presente trabajo analizamos los efectos del SUGAMADEX, la implicación del colesterol en los mismos y el posible papel protector del ROCURONIO y VECURONIO en cultivos primarios de neuronas de rata. HIPÓTESIS: Debido a la introducción paulatina del fármaco SUGAMADEX en la clínica y de los bloqueantes neuromusculares tipo ROCURONIO y VECURONIO, nos planteamos si estos fármacos o su combinación podrían ocasionar muerte neuronal en c…

Reactivity of asymmetric benzo-condensed diazines with nitrilimine dipoles in the 1,3-dipolar cycloaddition reactions

2009

The reactivity of asymmetric benzo-condensed diazines in the 1,3-dipolar cycloaddition reactions with nitrilimines was investigated. The results demonstrated that, at variance with the symmetric quinoxaline, a certain grade of diastereoselectivity emerged. Moreover in the case of the 5-methylquinoxaline and quinazoline a mono-cycloadduct was obtained.

Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays.

2017

Three polyaminocyclodextrin materials, obtained by direct reaction between heptakis(6-deoxy-6-iodo)-β-cyclodextrin and the proper linear polyamines, were investigated for their binding properties, in order to assess their potential applications in biological systems, such as vectors for simultaneous drug and gene cellular uptake or alternatively for the protection of macromolecules. In particular, we exploited polarimetry to test their interaction with some model p-nitroaniline derivatives, chosen as probe guests. The data obtained indicate that binding inside the host cavity is mainly affected by interplay between Coulomb interactions and conformational restraints. Moreover, simultaneous i…