Search results for "Positive"
showing 10 items of 1875 documents
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells
2015
The modification of proteins by ubiquitin has a major role in cells of the immune system and is counteracted by various deubiquitinating enzymes (DUBs) with poorly defined functions. Here we identified the ubiquitin-specific protease USP8 as a regulatory component of the T cell antigen receptor (TCR) signalosome that interacted with the adaptor Gads and the regulatory molecule 14-3-3β. Caspase-dependent processing of USP8 occurred after stimulation of the TCR. T cell-specific deletion of USP8 in mice revealed that USP8 was essential for thymocyte maturation and upregulation of the gene encoding the cytokine receptor IL-7Rα mediated by the transcription factor Foxo1. Mice with T cell-specifi…
The Contribution of Religiosity and Optimism on Well-Being of Youth and Emerging Adults in Italy
2017
In line with Positive Youth Development (PYD) framework positing that religion can provide youth with resources to thrive, this chapter presents a contribution analyzing the associations between religiosity and well-being among middle and late adolescents, and emerging adults in Italy. In fact, this country is a relevant context for studying this topic, considering the social and historical presence of Catholicism. We conceptualized religiosity as religious commitment and well-being as life satisfaction. Then, we focused on the mediating role of optimism between these two constructs and investigated differences among age groups concerning those associations. A multiple-group path analysis r…
Ethics and economics, friends or foes? An educational debate
2004
This paper reviews an ongoing debate about moral standards for vocational education in German speaking countries. At the centre of the controversy is the question of universalistic versus domain‐specific moral orientations, namely the question of whether business people ought to develop different moral points of view in different situations (such as ‘private’ versus ‘professional’). Of pivotal importance in this context is also a prominent ethical approach (by Karl Homann, a philosopher in the tradition of liberal economists) which serves as a foundation for those who advocate domain specificity and which is strongly criticized by their counterparts. This approach is also presented, since t…
Materialistic values impact on pro-environmental behavior: The case of transition country as Lithuania
2020
Abstract Materialism is becoming a global phenomenon and is increasing exponentially. Lithuania, which has survived a long period of occupation, experienced privatization and goods’ famine is attributed to the transition countries. In terms of materialistic values, Lithuania is not an exception, as material wealth and image are also very important. Thus, the main question of this paper was whether materialistic values could be reconciled with the pro-environmental behavior, which can be considered as one of the main aspects seeking sustainability. According to the Lithuanian representative survey and by applying the approach of structural equation modeling, the results showed that materiali…
A Positive Definite Advection Scheme Obtained by Nonlinear Renormalization of the Advective Fluxes
1989
Abstract A new method is developed to obtain a conservative and positive definite advection scheme that produces only small numerical diffusion. Advective fluxes are computed utilizing the integrated flux form of Tremback et al. These fluxes are normalized and then limited by upper and lower values. The resulting advection equation is numerically solved by means of the usual upstream procedure. The proposed treatment is not restricted to the integrated flux form but may also be applied to other known advection algorithms which are formulated in terms of advective fluxes. Different numerical tests are presented illustrating that the proposed scheme strongly reduces numerical and diffusion an…
Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): study protocol for a randomized controlled trial.
2012
Abstract Background Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with …
How prior knowledge, learning, teaching and assessment affect students’ achievements in Mathematics
2020
El objeto de este estudio es investigar la influencia del conocimiento previo del alumnado, el enfoque de aprendizaje integral, la enseñanza basada en problemas y el impacto de la evaluación en el aprendizaje básico del estudiante de matemáticas a nivel universitario. La investigación plantea un diseño de investigación cuasi experimental y un cuestionario estructurado. En él participaron dos grupos experimentales y dos grupos de control. Los resultados muestran que existe una correlación no significativa entre el conocimiento previo y la habilidad de aprendizaje básico; también plantea que un enfoque de aprendizaje integral se correlaciona positivamente con el conocimiento previo, mientras …
Towards a ‘Virtual’ Rationality?
1999
Psychology has, for a long time, shown the boundaries of human rationality. The rationalistic model of human behaviour assumed by neoclassical economics has broken down; the idea that companies are guided by managers who are able to weigh all the options and make the most rational or optimum decisions in accordance with maximizing principles, such as ‘profits’, cannot be held any more.
Survey of neonatal respiratory support use in very preterm infants in Italy
2012
Background: Respiratory support in very preterm infants is often a life-saving procedure and several techniques are available. There is lack of data on the current use of these techniques. Methods and aim: We analyzed a cohort of infants <30 weeks gestation or < 1501 g birth weight, enrolled in the Italian Neonatal Network in 2009 and 2010 (n = 8297, mean gestation = 29.3 weeks, mean birth weight = 1089 g) to ascertain the use of several techniques. We also conducted a questionnaire survey of all neonatal units adhering to the Italian Neonatal Network, inquiring about preferred methods of respiratory support. Results: Conventional ventilation was used in 53% of these infants, high frequency…
Event-related brain potentials of masked repetition and semantic priming while listening to sentences.
2012
We combined for the first time electrophysiological measures and masked priming technique in sentential context, by setting up a cross-modal masked priming paradigm involving the auditory presentation of sentences. ERPs were time-locked to an auditorily presented word that was preceded by a repeated, related or unrelated pattern masked prime. We registered a two-way N400-difference between unrelated and related/repeated primes, followed by a late positive component (LPC) for repetition priming. Related primes appear to facilitate the lexical-semantic processing of the target to the same extent repeated primes do (equally attenuated N400). Repetition priming exerts additional demands (LPC), …