Search results for "Precision"
showing 10 items of 448 documents
Comparison of UV and charged aerosol detection approach in pharmaceutical analysis of statins
2009
Abstract CAD (charged aerosol detector) has recently become a new alternative detection system in HPLC. This detection approach was applied in a new HPLC method for the determination of three of the major statins used in clinical treatment—simvastatin, lovastatin and atorvastatin. The method was optimized and the influence of individual parameters on CAD response and sensitivity was carefully studied. Chromatography was performed on a Zorbax Eclipse XDB C18 (4.6 mm × 75 mm, 3.5 μm), using acetonitrile and formic acid 0.1% as mobile phase. The detection was performed using both CAD (20 pA range) and DAD (diode array detector—238 nm) simultaneously connected in series. In terms of linearity, …
Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers
2021
The main epigenetic features in aging are: reduced bulk levels of core histones, altered pattern of histone post-translational modifications, changes in the pattern of DNA methylation, replacement of canonical histones with histone variants, and altered expression of non-coding RNA. The identification of epigenetic mechanisms may contribute to the early detection of age-associated subclinical changes or deficits at the molecular and/or cellular level, to predict the development of frailty, or even more interestingly, to improve health trajectories in older adults. Frailty reflects a state of increased vulnerability to stressors as a result of decreased physiologic reserves, and even dysregu…
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Valutazione di sistemi GPS e DGPS combinati con metodi di correzione e sistemi non satellitari
2000
The aim of this work is assess the accuracy of three positiotining systems: a hand-held GPS receiver, tested on itself and together with a pseudo-differential method; a DGPS system; a dead reckoning system. Test results suggest that, for row crops, the "corrected" GPS, the DGPS and the dead reckoning systems satisfy the accuracy requirement for mapping in post-processing soil and crop parameters. It is possible to improve the reliability of position resolution, by using a combined DGPS-dead reckoning system that overcomes the problems of signal weakening and obstruction.
Numerical evaluation of multiple polylogarithms
2004
Multiple polylogarithms appear in analytic calculations of higher order corrections in quantum field theory. In this article we study the numerical evaluation of multiple polylogarithms. We provide algorithms, which allow the evaluation for arbitrary complex arguments and without any restriction on the weight. We have implemented these algorithms with arbitrary precision arithmetic in C++ within the GiNaC framework.
Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model
2021
International audience; The introduction of personalized medicine (PM) has been a milestone in the history of medical therapy, because it has revolutionized the previous approach of treating the disease with that of treating the patient. It is known today that diseases can occur in different genetic variants, making specific treatments of proven efficacy necessary for a given endotype. Allergic diseases are particularly suitable for PM, because they meet the therapeutic success requirements, including a known molecular mechanism of the disease, a diagnostic tool for such disease, and a treatment blocking the mechanism. The stakes of PM in allergic patients are molecular diagnostics, to dete…
un approccio teorico-sperimentale per la ricostruzione del profilo trasversale di rotaie usurate
2012
La sovrastruttura ferroviaria durante la sua vita utile è sottoposta oltre ai carichi dinamici generati dai rotabili (azioni verticali, laterali, ecc.), anche ai carichi termici e ad azioni ambientali di varia natura. Tali sollecitazioni, interagendo sinergicamente tra loro, determinano il deterioramento della sovrastruttura ferroviaria inteso come discostamento dalla configurazione geometrica di progetto e l’usura dei singoli componenti del binario e della massicciata. Per valutare lo stato di efficienza della sovrastruttura è consuetudine far riferimento ad alcuni parametri geometrici del binario che, peraltro, permettono di formulare un giudizio oggettivo circa il livello di sicurezza of…
Statistical methods for the comparison of measurements derived from orthodontic imaging
2000
Biometric comparison procedures for dental imaging methods with continuous outcome were reviewed, mainly concentrating on assessment and comparison of accuracy and precision according to the study design. Univariate graphical and numerical representations of corresponding deviations were summarized to derive a 'check list' of minimum information necessary to compare the measurement methods. The methods reviewed in this investigation are illustrated by the comparison of conventional (radiographic) cephalometry versus assessment using the DigiGraph in 50 female children. A paired t-test and the corresponding confidence interval approach were used to assess deviations in location of two imagin…
Real-life assessment of chronic rhinosinusitis patients using mobile technology: the mySinusitisCoach project by EUFOREA
2020
Abstract Background Chronic rhinosinusitis (CRS) is a chronic inflammatory disease associated with a substantial personal and socioeconomic burden. Monitoring of patient‐reported outcomes by mobile technology offers the possibility to better understand real‐life burden of CRS. Methods This study reports on the cross‐sectional evaluation of data of 626 users of mySinusitisCoach (mSC), a mobile application for CRS patients. Patient characteristics of mSC users were analysed as well as the level of disease control based on VAS global rhinosinusitis symptom score and adapted EPOS criteria. Results The mSC cohort represents a heterogeneous group of CRS patients with a diverse pattern of major sy…
Artificial Intelligence and Precision Medicine: A Perspective
2022
This article aims to present how the advanced solutions of artificial intelligence and precision medicine work together to refine medical management. Multi-omics seems the most suitable approach for biological analysis of data on precision medicine and artificial intelligence. We searched PubMed and Google Scholar databases to collect pertinent articles appearing up to 5 March 2021. Genetics, oncology, radiology, and the recent coronavirus disease (COVID-19) pandemic were chosen as representative fields addressing the cross-compliance of artificial intelligence (AI) and precision medicine based on the highest number of articles, topicality, and interconnectedness of the issue. Overall, we i…