Search results for "Prevention."
showing 10 items of 1632 documents
Regression Modeling of the Antioxidant-to-Nephroprotective Relation Shows the Pivotal Role of Oxidative Stress in Cisplatin Nephrotoxicity
2021
The clinical utility of the chemotherapeutic drug cisplatin is significantly limited by its nephrotoxicity, which is characterized by electrolytic disorders, glomerular filtration rate decline, and azotemia. These alterations are consequences of a primary tubulopathy causing injury to proximal and distal epithelial cells, and thus tubular dysfunction. Oxidative stress plays a role in cisplatin nephrotoxicity and cytotoxicity, but its relative contribution to overall toxicity remains unknown. We studied the relation between the degree of oxidative reduction (provided by antioxidant treatment) and the extent of nephrotoxicity amelioration (i.e., nephroprotection) by means of a regression anal…
Prophylaxis of Non-communicable Diseases: Why fruits and vegetables may be better chemopreventive agents than dietary supplements based on isolated p…
2019
The World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases. The increasing knowledge on chemopreventive properties of certain food ingredients, in particular, those of plant origin, opened the discussion on the possibility to use edible plants or their active components in the prevention of these chronic diseases. Health-pro…
Influence of cultivar and concentration of selected phenolic constituents on the in vitro chemiopreventive potential of olive oil extracts.
2011
One of the main olive oil phenolic compounds, hydroxytyrosol (3,4-DHPEA), exerts in vitro chemopreventive activities (antiproliferative and pro-apoptotic) on tumor cells through the accumulation of H2O2 in the culture medium. However, the phenol composition of virgin olive oil is complex, and 3,4-DHPEA is present at low concentrations when compared to other secoiridoids. In this study, the in vitro chemopreventive activities of complex virgin olive oil phenolic extracts (VOO-PE, derived from the four Italian cultivars Nocellara del Belice, Coratina, Ogliarola, and Taggiasca) were compared to each other and related to the amount of the single phenolic constituents. A great chemopreventive po…
Perceived benefits and constraints in vehicle automation: Data to assess the relationship between driver's features and their attitudes towards auton…
2019
This data article examines the association driver's features, perceptions and attitudes towards autonomous vehicles (AVs). The data was collected using a structured self-administrable and online-based questionnaire, applied to a full sample of 1205 Spanish drivers. The data contains 4 parts: the full set of bivariate correlations between study variables; descriptive statistics and graphical trends for each main study variable according to gender, age group and city/town size; and, finally, the dataset for further explorations in this regard. For more information, it is convenient to read the full article entitled “Perceived safety and attributed value as predictors of the intention to use a…
On the impact of safety requirements, energy prices and investment costs in street lighting refurbishment design
2018
Abstract Street lighting is an indispensable feature for the night landscape of cities. It is important for road safety, users visual comfort, crime prevention and to augment the perceived personal safety. Realize and maintain an adequate street lighting service is very expensive for municipalities with significant impact on their budgets. For this reason, special attention should be paid to the design of new street lighting systems and to the refurbishment of existing ones, since many of them are inadequate. In light of this it is very important to implement street lighting designs that fulfil lighting requirements avoiding energy waste and light pollution and, at the same time, result eco…
Mapping child maltreatment risk: a 12-year spatio-temporal analysis of neighborhood influences.
2017
Abstract Background ‘Place’ matters in understanding prevalence variations and inequalities in child maltreatment risk. However, most studies examining ecological variations in child maltreatment risk fail to take into account the implications of the spatial and temporal dimensions of neighborhoods. In this study, we conduct a high-resolution small-area study to analyze the influence of neighborhood characteristics on the spatio-temporal epidemiology of child maltreatment risk. Methods We conducted a 12-year (2004–2015) small-area Bayesian spatio-temporal epidemiological study with all families with child maltreatment protection measures in the city of Valencia, Spain. As neighborhood units…
Artificial Intelligence for Cybersecurity: A Systematic Mapping of Literature
2020
Due to the ever-increasing complexities in cybercrimes, there is the need for cybersecurity methods to be more robust and intelligent. This will make defense mechanisms to be capable of making real-time decisions that can effectively respond to sophisticated attacks. To support this, both researchers and practitioners need to be familiar with current methods of ensuring cybersecurity (CyberSec). In particular, the use of artificial intelligence for combating cybercrimes. However, there is lack of summaries on artificial intelligent methods for combating cybercrimes. To address this knowledge gap, this study sampled 131 articles from two main scholarly databases (ACM digital library and IEEE…
Artificial intelligence to counteract “KPI overload” in business process monitoring: the case of anti-corruption in public organizations
2023
PurposeThe nature and amount of data that public organizations have to monitor to counteract corruption lead to a phenomenon called “KPI overload”, consisting of the business analyst feeling overwhelmed by the amount of information and resulting in the absence of appropriate control. The purpose of this study is to develop a solution based on Artificial Intelligence technology to avoid data overloading and, at the same time, under-controlling in business process monitoring.Design/methodology/approachThe authors adopted a design science research approach. The authors started by observing a specific problem in a real context (a healthcare organization); then conceptualized, designed and imple…
The effect of birthplace on heat tolerance and mortality in Milan, Italy, 1980-1989
2006
The temperature–mortality relationship follows a well-known J-V shaped pattern with mortality excesses recorded at cold and hot temperatures, and minimum at some optimal value, referred as Minimum Mortality Temperature (MMT). As the MMT, which is used to measure the population heat-tolerance, is higher for people living in warmer places, it has been argued that populations will adapt to temperature changes. We tested this notion by taking advantage of a huge migratory flow that occurred in Italy during the 1950s, when a large number of unemployed people moved from the southern to the industrializing north-western regions. We have analyzed mortality–temperature relationships in Milan residen…
Nature of screen violence and its relation to program popularity
1997
This study was designed to analyze the context-specific variation in the amount, intensity, and attractiveness of screen violence in Finnish network TV programs (n = 259). The additional aim was to investigate whether the violence content enhances the popularity of a program. Typically, the frequency and intensity of violent constructions varied with program type, and with cultural and temporal settings, but the attractiveness of violence varied only with program type. Violence in non-fiction was generally less frequent, less intense, and less attractive than that in fiction. U.S. fiction contained violence more frequently than Finnish fiction, while violence in exported European films was,…