Search results for "Prior probability"
showing 10 items of 47 documents
Applications and Limitations of Robust Bayesian Bounds and Type II MLE
1994
Three applications of robust Bayesian analysis and three examples of its limitations are given. The applications that are reviewed are the development of an automatic Ockham’s Razor, outlier detection, and analysis of weighted distributions. Limitations of robust Bayesian bounds are highlighted through examples that include analysis of a paranormal experiment and a hierarchical model. This last example shows a disturbing difference between actual hierarchical Bayesian analysis and robust Bayesian bounds, a difference which also arises if, instead, a Type II MLE or empirical Bayes analysis is performed.
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.
2022
Background: Molecular measurements of the genome, the transcriptome, and the epigenome, often termed multi-omics data, provide an in-depth view on biological systems and their integration is crucial for gaining insights in complex regulatory processes. These data can be used to explain disease related genetic variants by linking them to intermediate molecular traits (quantitative trait loci, QTL). Molecular networks regulating cellular processes leave footprints in QTL results as so-called trans-QTL hotspots. Reconstructing these networks is a complex endeavor and use of biological prior information can improve network inference. However, previous efforts were limited in the types of priors…
The Effective Sample Size
2013
Model selection procedures often depend explicitly on the sample size n of the experiment. One example is the Bayesian information criterion (BIC) criterion and another is the use of Zellner–Siow priors in Bayesian model selection. Sample size is well-defined if one has i.i.d real observations, but is not well-defined for vector observations or in non-i.i.d. settings; extensions of critera such as BIC to such settings thus requires a definition of effective sample size that applies also in such cases. A definition of effective sample size that applies to fairly general linear models is proposed and illustrated in a variety of situations. The definition is also used to propose a suitable ‘sc…
WEIGHTED-AVERAGE LEAST SQUARES (WALS): A SURVEY
2014
Model averaging has become a popular method of estimation, following increasing evidence that model selection and estimation should be treated as one joint procedure. Weighted- average least squares (WALS) is a recent model-average approach, which takes an intermediate position between frequentist and Bayesian methods, allows a credible treatment of ignorance, and is extremely fast to compute. We review the theory of WALS and discuss extensions and applications.
Bayesian Checking of the Second Levels of Hierarchical Models
2007
Hierarchical models are increasingly used in many applications. Along with this increased use comes a desire to investigate whether the model is compatible with the observed data. Bayesian methods are well suited to eliminate the many (nuisance) parameters in these complicated models; in this paper we investigate Bayesian methods for model checking. Since we contemplate model checking as a preliminary, exploratory analysis, we concentrate on objective Bayesian methods in which careful specification of an informative prior distribution is avoided. Numerous examples are given and different proposals are investigated and critically compared.
Fast Estimation of Diffusion Tensors under Rician noise by the EM algorithm
2016
Diffusion tensor imaging (DTI) is widely used to characterize, in vivo, the white matter of the central nerve system (CNS). This biological tissue contains much anatomic, structural and orientational information of fibers in human brain. Spectral data from the displacement distribution of water molecules located in the brain tissue are collected by a magnetic resonance scanner and acquired in the Fourier domain. After the Fourier inversion, the noise distribution is Gaussian in both real and imaginary parts and, as a consequence, the recorded magnitude data are corrupted by Rician noise. Statistical estimation of diffusion leads a non-linear regression problem. In this paper, we present a f…
Sequential Monte Carlo Methods in Random Intercept Models for Longitudinal Data
2017
Longitudinal modelling is common in the field of Biostatistical research. In some studies, it becomes mandatory to update posterior distributions based on new data in order to perform inferential process on-line. In such situations, the use of posterior distribution as the prior distribution in the new application of the Bayes’ theorem is sensible. However, the analytic form of the posterior distribution is not always available and we only have an approximated sample of it, thus making the process “not-so-easy”. Equivalent inferences could be obtained through a Bayesian inferential process based on the set that integrates the old and new data. Nevertheless, this is not always a real alterna…
Bayesian approach for uncertainty quantification in water quality modelling: The influence of prior distribution
2010
Summary Mathematical models are of common use in urban drainage, and they are increasingly being applied to support decisions about design and alternative management strategies. In this context, uncertainty analysis is of undoubted necessity in urban drainage modelling. However, despite the crucial role played by uncertainty quantification, several methodological aspects need to be clarified and deserve further investigation, especially in water quality modelling. One of them is related to the “a priori” hypotheses involved in the uncertainty analysis. Such hypotheses are usually condensed in “a priori” distributions assessing the most likely values for model parameters. This paper explores…
Can bayesian models play a role in dental caries epidemiology? Evidence from an application to the BELCAP data set
2012
Objectives The aim of this study was to show the potential of Bayesian analysis in statistical modelling of dental caries data. Because of the bounded nature of the dmft (DMFT) index, zero-inflated binomial (ZIB) and beta-binomial (ZIBB) models were considered. The effects of incorporating prior information available about the parameters of models were also shown. Methods The data set used in this study was the Belo Horizonte Caries Prevention (BELCAP) study (Bohning et al. (1999)), consisting of five variables collected among 797 Brazilian school children designed to evaluate four programmes for reducing caries. Only the eight primary molar teeth were considered in the data set. A data aug…
Inventory Control Under Parametric Uncertainty of Underlying Models
2013
A large number of problems in inventory control, production planning and scheduling, location, transportation, finance, and engineering design require that decisions be made in the presence of uncertainty of underlying models. In the present paper we consider the case, where it is known that the underlying distribution belongs to a parametric family of distributions. The problem of determining an optimal decision rule in the absence of complete information about the underlying distribution, i.e., when we specify only the functional form of the distribution and leave some or all of its parameters unspecified, is seen to be a standard problem of statistical estimation. Unfortunately, the clas…