Search results for "Profilin"
showing 10 items of 900 documents
T100: A modern classic ensemble to profile irony and stereotype spreaders
2022
In this work we propose a novel ensemble model based on deep learning and non-deep learning classifiers. The proposed model was developed by our team for participating at the Profiling Irony and Stereotype Spreaders (ISSs) task hosted at PAN@CLEF2022. Our ensemble (named T100), include a Logistic Regressor (LR) that classifies an author as ISS or not (nISS) considering the predictions provided by a first stage of classifiers. All these classifiers are able to reach state-of-the-art results on several text classification tasks. These classifiers (namely, the voters) are a Convolutional Neural Network (CNN), a Support Vector Machine (SVM), a Decision Tree (DT) and a Naive Bayes (NB) classifie…
Fake News Spreaders Detection: Sometimes Attention Is Not All You Need
2022
Guided by a corpus linguistics approach, in this article we present a comparative evaluation of State-of-the-Art (SotA) models, with a special focus on Transformers, to address the task of Fake News Spreaders (i.e., users that share Fake News) detection. First, we explore the reference multilingual dataset for the considered task, exploiting corpus linguistics techniques, such as chi-square test, keywords and Word Sketch. Second, we perform experiments on several models for Natural Language Processing. Third, we perform a comparative evaluation using the most recent Transformer-based models (RoBERTa, DistilBERT, BERT, XLNet, ELECTRA, Longformer) and other deep and non-deep SotA models (CNN,…
miRNA Signature and Dicer Requirement during Human Endometrial Stromal Decidualization In Vitro
2012
Decidualization is a morphological and biochemical transformation of endometrial stromal fibroblast into differentiated decidual cells, which is critical for embryo implantation and pregnancy establishment. The complex regulatory networks have been elucidated at both the transcriptome and the proteome levels, however very little is known about the post-transcriptional regulation of this process. miRNAs regulate multiple physiological pathways and their de-regulation is associated with human disorders including gynaecological conditions such as endometriosis and preeclampsia. In this study we profile the miRNAs expression throughout human endometrial stromal (hESCs) decidualization and analy…
Transcriptomic identification of miR-205 target genes potentially involved in metastasis and survival of cutaneous malignant melanoma
2020
AbstractCutaneous melanoma is an aggressive neoplasm and is responsible for the majority of skin cancer deaths. Several miRNAs are involved in melanoma tumor progression. One of them is miR-205, the loss of which contributes to the development of melanoma metastasis. We evaluated whole-genome mRNA expression profiling associated with different miR-205 expression levels in melanoma cells. Differential expression analysis identified 243 differentially expressed transcripts including inositol polyphosphate 5′-phosphatase-like protein-1 (INPPL1) and BTB/POZ Domain-Containing Protein 3 (BTBD3). INPPL1 and BTBD3 were downregulated when melanoma cells expressed miR-205, indicating that these genes…
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
2014
Mutations in the cytosine-5 RNA methyltransferase NSun2 cause microcephaly and other neurological abnormalities in mice and human. How post-transcriptional methylation contributes to the human disease is currently unknown. By comparing gene expression data with global cytosine-5 RNA methylomes in patient fibroblasts and NSun2-deficient mice, we find that loss of cytosine-5 RNA methylation increases the angiogenin-mediated endonucleolytic cleavage of transfer RNAs (tRNA) leading to an accumulation of 5' tRNA-derived small RNA fragments. Accumulation of 5' tRNA fragments in the absence of NSun2 reduces protein translation rates and activates stress pathways leading to reduced cell siz…
Smartphone Usage Among Millennial in Finland and Implications for Marketing Segmentation Strategies: Lessons for Nigeria
2018
The study examines smart phone usage by millennials based on different criteria of operating system, Wi-Fi, text messaging, internet surfing and social media. The study used quantitative methodology and data were gathered with online questionnaires with 391 young smartphone users in Finland. The Millennial were clustered into five levels. The results reveal the prominent status of profiling in a developed market and how marketers in emerging markets can apply segmentation and targeting strategies using instant messaging, text messages, email, mobile app, gamification and social media based on the profile of each segment. Nigerian policy makers should adopt a framework to make smartphone aff…
Adolescents' engagement profiles and their association with academic performance and situational engagement
2020
Abstract This study examined adolescents' engagement profiles and their association with situational engagement and academic performance in lower secondary school settings. The data consisted of 301 Grade 7 students from Finland. By utilizing person-oriented approach with Latent Profiling Analysis on subscales capturing students' overall engagement, four subgroups of students with different overall engagement profiles were identified. These profile groups were further analyzed with respect to differences in student background (gender and maternal education), academic performance (GPA, and reading and mathematics tests), and lesson-specific situational engagement. The profile groups showed d…
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societi…
2021
The personalized medicine is in a rapidly evolving scenario. The identification of actionable mutations is revolutionizing the therapeutic landscape of tumors. The morphological and histological tumor features are enriched by the extensive genomic profiling, and the first tumor-agnostic drugs have been approved regardless of tumor histology, guided by predictive and druggable genetic alterations. This new paradigm of "mutational oncology", presents a great potential to change the oncologic therapeutic scenario, but also some critical aspects need to be underlined. A process governance is mandatory to ensure the genomic testing accuracy and homogeneity, the economic sustainability, and the r…
The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-S…
2022
The development of innovative technologies and the advances in the genetics and genomics, have offered new opportunities for personalized treatment in oncology. Although the selection of the patient based on the molecular characteristics of the neoplasm has the potential to revolutionize the therapeutic scenario of oncology, this approach is extremely challenging. The access, homogeneity, and economic sustainability of the required genomic tests should be warranted in the clinical practice, as well as the specific scientific and clinical expertise for the choice of medical therapies. All these elements make essential the collaboration of different specialists within the Molecular Tumor Boar…
Protein and DNA fingerprinting of a soil bacterial community inoculated into three different sterile soils
2007
The functional and genetic structures of a soil bacterial community were characterized after inoculation into three different sterile soils using a protein and DNA fingerprinting method, respectively. Principal component analysis (PCA) of profiles revealed that, depending on soil characteristics, bacterial communities with similar genetic structures harbored different functional structures and thus could potentially be of differing ecological significance for soil functioning. Co-inertia analysis between protein fingerprinting data and the corresponding sets of soil physicochemical characteristics demonstrated the correlation between the functional structure of the bacterial community and s…