Search results for "Progression"

A comparison theorem for the first Dirichlet eigenvalue of a domain in a Kaehler submanifold

1994

AbstractWe give a sharp lower bound for the first eigenvalue of the Dirichlet eigenvalue problem on a domain of a complex submanifold of a Kaehler manifold with curvature bounded from above. The bound on the first eigenvalue is given as a function of the extrinsic outer radius and the bounds on the curvature, and it is attained only on geodesic spheres of a space of constant holomorphic sectional curvature embedded in the Kaehler manifold as a totally geodesic submanifold.

Effectiveness of interventions to prevent pre-frailty and frailty progression in older adults: a systematic review

2018

OBJECTIVE: To summarize the best available evidence regarding the effectiveness of interventions for preventing frailty progression in older adults. INTRODUCTION: Frailty is an age-related state of decreased physiological reserves characterized by an increased risk of poor clinical outcomes. Evidence supporting the malleability of frailty, its prevention and treatment, has been presented. INCLUSION CRITERIA: The review considered studies on older adults aged 65 and over, explicitly identified as pre-frail or frail, who had been undergoing interventions focusing on the prevention of frailty progression. Participants selected on the basis of specific illness or with a terminal diagnosis were …

Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIP…

2016

Introduction: Mild cognitive impairment (MCI) is a term used to describe a level of decline in cognition which is seen as an intermediate stage between normal ageing and dementia, and which many consider to be a prodromal stage of neurodegeneration that may become dementia. That is, it is perceived as a high risk level of cognitive change. The increasing burden of dementia in our society, but also our increasing understanding of its risk factors and potential interventions, require diligent management of MCI in order to find strategies that produce effective prevention of dementia. Aim: To update knowledge regarding mild cognitive impairment, and to bring together and appraise evidence abou…

A realist review to understand the efficacy and outcomes of interventions designed to minimise, reverse or prevent the progression of frailty.

2018

Interventions to minimise, reverse or prevent the progression of frailty in older adults represent a potentially viable route to improving quality of life and care needs in older adults. Intervention methods used across European Innovation Partnership on Active and Healthy Ageing collaborators were analysed, along with findings from literature reviews to determine 'what works for whom in what circumstances'. A realist review of FOCUS study literature reviews, 'real-world' studies and grey literature was conducted according to RAMESES (Realist and Meta-narrative Evidence Synthesis: Evolving Standards), and used to populate a framework analysis of theories of why frailty interventions worked,…

Effectiveness of the interventions in preventing the progression of pre-frailty and frailty in older adults: a systematic review protocol

2016

REVIEW QUESTION / OBJECTIVE : The objective of this review is to identify the effectiveness of the interventions in preventing progression of pre-frailty and frailty in older adults. More specifically, the review questions are: - What is the effectiveness of interventions in preventing or reducing frailty in older adults? - How does effectiveness vary with degree of frailty? - Are there factors that influence the effectiveness of interventions? - What is the economic feasibility of interventions for pre-frailty and frailty? INCLUSION CRITERIA : Types of participants This review will consider studies that include older adults (female and male) aged 65 years and over, explicitly identified as…

Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia

2013

Abstract Background Physical activity may be beneficial for cognition, but the effect may vary depending on personal characteristics. Methods We investigated the associations between leisure-time physical activity (LTPA) from mid- to late life, the risk of dementia, and the role of body mass index, sex, and APOE in the CAIDE study during 28-year follow-up. Cognitive function of a random subsample was assessed at a mean age of 78.8 years (n = 1511), and dementia/Alzheimer's disease (AD) diagnoses were identified from national registers for the entire target population (n = 3559). Results Moderate (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.08–1.99) and low levels of midlife LTP…

β-arrestin: Dr Jekyll and Mr Hyde in NASH and fibrosis.

2020

Early diagnosis of colorectal cancer. Diagnostic delay reduction or rather screening programs?

2006

Tuberkulose 2019 – eine Herausforderung auch für die Radiologie

2019

Raynaud-Phänomen bei einer beruflichen Vibrationsbelastung

2013

Anamnese und klinischer Befund: Eine 34-jahrige Steinmetzin wurde mit der Fragestellung eines vibrationsbedingten vasospastischen Syndroms (VVS) begutachtet. Ihre Hande waren langjahrig gegenuber den hochfrequenten Schwingungen verschiedener Werkzeuge exponiert gewesen. Die Patientin berichtete uber Weisfingeranfalle an den Langfingern, die bei Kalte aufgetreten waren. Der korperliche Befund war zu diesem Zeitpunkt regelrecht. Untersuchungen: Der Kaltwasserprovokationstest zeigte an den Langfingern der rechten Hand eine leicht verzogerte Wiedererwarmung; die Kapillarmikroskopie der Finger war regelrecht. Diagnose und Verlauf: Das leichtgradige Raynaud-Phanomen wurde als Berufskrankheit der …