Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia

6533b7dafe1ef96bd126e3da

RESEARCH PRODUCT

Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia

Alina Solomon Alina Solomon Minna Rusanen Tiia Ngandu Tiia Ngandu Jenni Kulmala Ingemar Kåreholt Ingemar Kåreholt Miia Kivipelto Tiina Laatikainen Tiina Laatikainen Anna-maija Tolppanen Hilkka Soininen

subject

Gerontology Male Epidemiology Neuroimaging Overweight Motor Activity Neuropsychological Tests Community Health Planning Body Mass Index Cellular and Molecular Neuroscience Leisure Activities Developmental Neuroscience Risk Factors medicine Dementia Humans Longitudinal Studies Obesity Exercise Finland Aged Proportional Hazards Models 2. Zero hunger Aged 80 and over Psychiatric Status Rating Scales Physical activity Health Policy Hazard ratio Age Factors Life course ta3142 Middle Aged medicine.disease Obesity Confidence interval 3. Good health Psychiatry and Mental health Disease Progression Life course approach Female Dementia Neurology (clinical)Geriatrics and Gerontology medicine.symptom Psychology Cohort study Body mass index Cohort study

description

Abstract Background Physical activity may be beneficial for cognition, but the effect may vary depending on personal characteristics. Methods We investigated the associations between leisure-time physical activity (LTPA) from mid- to late life, the risk of dementia, and the role of body mass index, sex, and APOE in the CAIDE study during 28-year follow-up. Cognitive function of a random subsample was assessed at a mean age of 78.8 years (n = 1511), and dementia/Alzheimer's disease (AD) diagnoses were identified from national registers for the entire target population (n = 3559). Results Moderate (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.08–1.99) and low levels of midlife LTPA (HR, 1.39; 95% CI, 0.99–1.95) were associated with higher risk of dementia in comparison with the most active category. The benefits were more pronounced among men, overweight individuals, and APOE e4 noncarriers. Maintaining high LTPA (HR, 0.16; 95% CI, 0.06–0.41) or increasing LTPA (HR, 0.19; 95% CI, 0.09–0.40) after midlife was associated with lower dementia risk. Similar results were observed for AD. Conclusions The window of opportunity for preventive physical activity interventions may extend from midlife to older ages.

year	journal	country	edition	language
2013-10-23	Alzheimers and Dementia

10.1016/j.jalz.2014.01.008 https://doi.org/10.1016/j.jalz.2014.01.008