Search results for "Project"
showing 10 items of 3466 documents
Flanking regions determine the structure of the poly-glutamine homo- repeat in huntingtin through mechanisms common among glutamine-rich human protei…
2020
International audience; The causative agent of Huntington's disease, the poly-Q homo-repeat in the N-terminal region of huntingtin (httex1), is flanked by a 17-residue-long fragment (N17) and a proline-rich region (PRR), which promote and inhibit the aggregation propensity of the protein, respectively, by poorly understood mechanisms. Based on experimental data obtained from site-specifically labeled NMR samples, we derived an ensemble model of httex1 that identified both flanking regions as opposing poly-Q secondary structure promoters. While N17 triggers helicity through a promiscuous hydrogen bond network involving the side chains of the first glutamines in the poly-Q tract, the PRR prom…
La representación sindical en España: cobertura y límites
2018
El objetivo de este artículo es realizar una aproximación al sistema de representación unitaria en la empresa en España a partir de una explotación estadística de los datos de las elecciones sindicales. Se trata de conocer aspectos como el alcance de la representación unitaria, la participación de los asalariados y la audiencia electoral de los sindicatos, con el objetivo de delimitar su representatividad y legitimidad. Nuestro trabajo se centra en el análisis de los tres últimos períodos electorales (2003-2007, 2007-2012 y 2012-2015), con objeto de evaluar el impacto del ciclo económico sobre la representación de los asalariados. The objective of this article is to make an approach to the …
Components of software development risk: how to address them? A project manager survey
2000
Software risk management can be defined as an attempt to formalize risk oriented correlates of development success into a readily applicable set of principles and practices. By using a survey instrument we investigate this claim further. The investigation addresses the following questions: 1) What are the components of software development risk? 2) how does risk management mitigate risk components, and 3) what environmental factors if any influence them? Using principal component analysis we identify six software risk components: 1) scheduling and timing risks, 2) functionality risks, 3) subcontracting risks, 4) requirements management, 5) resource usage and performance risks, and 6) person…
The sharing of research data in the cell & Tissue engineering area: Is it a common practice?
2018
The availability of research data sets is an important milestone because it can enhance the dynamics of research. This study aims to analyze the PubMed Central repository to determine the availability and type of raw data sets in Cell & Tissue Engineering journals indexed in Journal Citation Reports. The number and types of files were registered. The main finding of this study is that, beyond the mandatory deposit of data in specific repositories that some journals require, the exchange of data as supplementary material in the Cell & Tissue Engineering journals is not a common practice since researchers are still reticent to do so.
Strategic Analysis Tools Application at SMEs in Ecuador
2015
This article explores the nature and scope of Strategic Analysis Tools (SAT) application in SMEs located in emerging countries such as Ecuador (where there are no formal studies on the subject). It is intended to assess which of the instruments utilized by these firms may contribute to formulate strategic options and which of them create awareness of relevant risks or distress specifically about continuity concerning their operations. Through the application of a survey to an intentional sample-selection of SMEs in Quito-Ecuador we analyzed the consciousness over these instruments to facilitate the creation of strategic options, their contribution to assess their competitive position and th…
First results of PACTE group's experimental research on translation competence acquisition : the acquisition of declarative knowledge of translation
2014
Autors llistats per ordre alfabètic. Investigadora principal: A. Hurtado Albir This paper presents the first results of empirical-experimental research into the Acquisition of Translation Competence (ATC): the acquisition of declarative knowledge about translation. This study is based on our previous research about Translation Competence (TC). Some of the data collection instruments have, however, been adapted for current use. Details of our research design include type of study, universe and sample population, study variables, data collection instruments, and data analysis processes. The dependent variables were knowledge of translation; translation project; identification and solution of …
Development and validation of the coach's task presentation scale: A quantitative self-report instrument
2016
Abstract Objective A major concern for coaches is the transmission of effective information in the moments before sport practice, when they communicate to players what they are supposed to do and how (Rink, 1994). The present study's main objective was to cover a gap in the sport psychology measurement field and to develop and validate a quantitative self-report instrument to measure the effectiveness of coaches' task presentation for athletes. The resulting instrument was the Escala de Presentacion de las Tareas por Parte del Entrenador (EPTE ) [Coach's Task Presentation Scale]. Design The two studies developed to validate the EPTE used a cross-sectional research design. Method Participant…
Misguided Effort with Elusive Implications
2016
Good self-control has been linked to adaptive outcomes such as better health, cohesive personal relationships, success in the workplace and at school, and less susceptibility to crime and addictions. In contrast, self-control failure is linked to maladaptive outcomes. Understanding the mechanisms by which self-control predicts behavior may assist in promoting better regulation and outcomes. A popular approach to understanding self-control is the strength or resource depletion model. Self-control is conceptualized as a limited resource that becomes depleted after a period of exertion resulting in self-control failure. The model has typically been tested using a sequential-task experimental p…
ERP Implementation in an SME: A Failure Case
2013
This study examines a failed enterprise resource planning (ERP) implementation in a small-and-medium-sized enterprise (SME). The improper handling of critical success factors (CSFs), particularly those relating to support from top management, project management, and the use of consultants, led to severe problems. This placed stress on the organization, caused employees to leave the company, workarounds, and led to serious errors in the systems and a significant cost overrun. This case study contributes to the literature on ERP implementation in SMEs. In particular, it contributes to our understanding of the socio-technical dynamics of ERP implementation projects. Failed ERP cases are little…
An Adaptive Routing Mechanism for Efficient Resource Discovery in Unstructured P2P Networks
2005
The widespread adoption of large-scale decentralized peer-to-peer (P2P) systems imposes huge challenges on distributed search and routing. Decentralized and unstructured P2P networks are very attractive because they require neither centralized directories, nor precise control over network topology or data placement. However their search mechanisms are extremely unscalable, generating large loads on the network participants. In this paper, to address this major limitation, we propose and evaluate the adoption of an innovative algorithm for routing user queries. The proposed approach aims at dynamically adapting the network topology to peer interests, on the basis of query interactions among …