Search results for "Psychosi"

Integrated treatment of first episode psychosis with online training (e-learning): study protocol for a randomised controlled trial

2014

Background: The integrated treatment of first episode psychosis has been shown to improve functionality and negative symptoms in previous studies. In this paper, we describe a study of integrated treatment (individual psychoeducation complementary to pharmacotherapy) versus treatment as usual, comparing results at baseline with those at 6-month re-assessment (at the end of the study) for these patients, and online training of professionals to provide this complementary treatment, with the following objectives: 1) to compare the efficacy of individual psychoeducation as add-on treatment versus treatment as usual in improving psychotic and mood symptoms; 2) to compare adherence to medication,…

Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations

2014

European Community Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. in this article, we aim to review these recent developments and illustrate h…

Use of multiple polygenic risk scores for distinguishing schizophrenia-spectrum disorder and affective psychosis categories in a first-episode sample…

2022

This work was supported by funding from the European Community’s Seventh Framework Programme under grant agreement No. HEALTH-F2-2010-241909 (Project EU-GEI). (...) CA was supported by the Spanish Ministry of Science and Innovation; Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, PI19/024), co-financed by ERDF Funds from the European Commission, ‘A way of making Europe’, CIBERSAM. Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), Fundación Familia Alonso and Fundación Alicia Koplowitz. MB was supported by the Ministry of Economy and Competitivity (PI08/0208; PI11/00325; PI14/00612), Instituto de Salud Carlos III – ERDF Funds from the European Commission, ‘A way of making Europ…

PREVALENCE OF BULLYING AMONGST FIRST-EPISODE PSYCHOSIS PATIENTS AND UNAFFECTED CONTROLS

2012

Background:Despite increasing evidence suggesting that childhood mal-treatment is significantly associated with psychotic disorders, the role ofbullying in the later development of psychosis is still controversial (Kelle-her et al., 2008, Arseneault et al., 2011). Therefore, this study examinedthe prevalence of bullying amongst first-episode psychosis patients andunaffected controlsMethods:Data were collected from 227 first-presentation psychosis casesand 215 geographically-matched controls. Bullying was assessed as partof the Brief Life Events schedule. Patients and controls were shown acard listing 10 adverse events, including “bullying”, “sexual abuse”, “beingexpelled from school”, and a…

Educational achievement, cannabis use, and genotype in predicting psychosis

2006

Current and/ or life time use of cannabis as a factor of vulnerability in psychotic disorders

2014

Smoke High-Potency Cannabis and Become Psychotic Younger?

2016

PURPOSE: Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the reasons for this remain debated. METHODS: We applied a Cox proportional hazards model to 410 first-episode psychosis patients to investigate the association between gender, patterns of cannabis use, and AOP. RESULTS: Patients with a history of cannabis use presented with their first episode of psychosis at a younger age (mean years = 28.2, SD = 8.0; median years = 27.1) than those who never used cannabis (mean years = 31.4, SD = 9.9; median years = 30.0; hazard ratio [HR] = 1.42; 95% CI: 1.16-1.74; P < .001). This association remained significant after controlling for gender (HR = 1.39; 95% …

SOME OF THE INDIVIDUAL DIFFERENCES IN RISK TO DEVELOP PSYCHOSIS AMONG CANNABIS USERS CAN BE EXPLAINED BY WHERE THEY LIVE AND BY THEIR AGE AT FIRST USE

2018

Background Cannabis use remains the most widely used recreational drug worldwide. Following from several USA states legalisation policies, European countries are reconsidering their cannabis laws. While a significant amount of Epidemiological evidence has reported that cannabis use increases the risk of psychosis it is still unclear: 1) what underpins individual differences in developing a psychotic disorder following cannabis use; 2) if variations in availability of cannabis have affected rate of Psychotic disorders across Europe. Methods Using detailed data on lifetime pattern of cannabis use from the EUGEI first episode case-control study (N=2300) and the available Incidence rates of Psy…

Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: results from the…

2021

European Community's Seventh Framework Program, European Commission [HEALTH-F2-2009-241909]; Scientific and Technological Research Council of Turkey, 2219 International Postdoctoral Research Fellowship Program; Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (SAM16PE07CP1, PI16/02012, and PI19/024)...

PREMORBID ADJUSTMENT AND CANNABIS USE IN FIRST-EPISODE-PSYCHOSIS PATIENTS. A CROSS-EUROPEAN CASE-CONTROL STUDY

The harmful effects of cannabis use and possible neuropsychological impairment associated with its use are a contentious topic of debate in both research and public health,as is thefact that cannabis use has been repeatedly shown to be a risk factor for the development of psychosis. Surprisingly, three different meta-analyses on cognition and cannabis, among schizophrenic patients, found better cognitive performance in patients with a lifetime use of cannabis (Potvin, Joyal, Pelletier, & Stip, 2008; Rabin, Zakzanis, & George, 2011; Yücel et al., 2012). This counterintuitive finding, coupled with the fact that most psychotic patients suffer from cognitive impairment (Reichenberg et al., 2009…