Search results for "Purini"
showing 9 items of 29 documents
�ber die Wirkung von Apurins�ure und Apyrimidins�ure auf die enzymatische Desoxyribonukleins�ure-(DNA-) Synthese in vitro
1970
The effect of chemically modified deoxyribonucleic acid (DNA) on enzymatic DNA-synthesis in vitro has been investigated with analogues of DNA prepared without either purine bases (apurinic acid, APA) or pyrimidine bases (apyrimidinic acid, APyA). DNA-synthesis in vitro was studied with the deoxynucleotide polymerizing enzymes purified from calf thymus (replicative and terminal deoxynucleotidyltransferase respectively).
Hemmung von DNA-Synthese und Zellvermehrung durch Apurins�ure und Apyrimidins�ure
1968
Apurinic acid (APA) and apyrimidinic acid (APyA) prepared from deoxyribonucleic acid (DNA) by removing either purine or pyrimidine bases have been reported to inhibit enzymatic DNA-synthesis in vitro (Heicke, 1970). The present paper deals with in vivo effects of APA and APyA on mammalian cells in tissue culture.
Uno stacco verso il cielo nei territori dell'EUR
2019
La torre Eurosky, dello Studio Purini/Thermes, accarezza il cielo di Roma. Da lontano la sua grammatica espressiva sembra suggerire l’emergere di un nuovo confronto fra un’architettura realizzata e la città in divenire. Questa si colloca come elemento di forte identità in un più ampio contesto che - messo a punto in un masterplan, sempre da Purini - definisce l’intera area di progetto dell’Europarco Castellaccio, a ridosso dell’EUR. The Eurosky tower, by Studio Purini / Thermes, caresses the sky of Rome. From a distance, its expressive grammar seems to suggest the emergence of a new comparison between a completed architecture and the city in the making. This is placed as an element of stron…
Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents.
1997
Abasic sites represent ubiquitous DNA lesions that arise spontaneously or are induced by DNA-damaging agents. They block DNA replication and are considered to be cytotoxic and mutagenic. The key enzymes involved in the repair of abasic sites are apurinic/apyrimidinic (AP) endonucleases which process these lesions in an error-free mechanism. To analyze the role of AP endonuclease in the protection of mammalian cells against DNA damaging agents, we have transfected both the human (APE) and the yeast (APN1) AP endonuclease in Chinese hamster cells and compared the effects of expression of these genes in stable transfectants as to survival of cells and formation of chromosomal aberrations. Alth…
The gardens of creative sloth
2006
The space for gardens defines VEMA's connective tissue. This is porous and labyrinthine system, ready for a process ao progressive appropriation on the part of the future inhabetants. the open structure is a reinterpretation, brought up to date, of the park of Le Corbusier's Ville Radieuse. This space is combined with service micro-structures, that will increase the opportunities for interchange between individuals.
Tra le modernità dell’architettura. La questione del quartiere ZEN 2 di Palermo
2003
La “questione” del quartiere ZEN 2 di Palermo è una delle più controverse dell’ultimo trentennio della storia dell’architettura italiana. Dal 1970, anno in cui venne bandito il concorso nazionale per il completamento del quartiere (Zona Espansione Nord), attraverso un percorso complesso e problematico, si giunge all’attuale condizione di incompletezza dello ZEN, ormai abbandonato al destino di “quartiere dormitorio”. Il libro percorre i vari passaggi, dal progetto alla realizzazione, che hanno generato la questione dello ZEN 2, sviscerandone le cause determinanti che vanno ben oltre l’esecuzione parziale dell’opera e il suo degrado materiale e sociale, ma sono da rintracciare in motivazioni…
Italianità e mediterraneità dell'architettura : Purini e la Sicilia
2017
Il saggio attiene al lavoro di Franco Purini in Sicilia, alla luce delle sue considerazioni sulla specificità dell'architettura italiana
CCDC 616111: Experimental Crystal Structure Determination
2006
Related Article: A.Valkonen, K.Ahonen, E.Kolehmainen|2006|Acta Crystallogr.,Sect.C:Cryst.Struct.Commun.|62|m290|doi:10.1107/S0108270106019469
Transcriptional activation of apurinic/apyrimidinic endonuclease (Ape, Ref-1) by oxidative stress requires CREB.
1999
Abstract Apurinic/apyrimidinic endonuclease (APE alias Ref-1) is a multifunctional enzyme involved in DNA repair and redox regulation of transcription factors (e.g., AP-1). It also acts as a repressor of its own and other genes. Recently, it was shown that the level of APE mRNA and protein is enhanced upon treatment of cells with oxidative agents, such as hydrogen peroxide (H 2 O 2 ), which gives rise to an adaptive response of cells to oxidative stress. Induction of APE is due to APE promoter activation. To elucidate the mechanism of transcriptional activation of APE by oxidative agents, we introduced mutations into the cloned human APE promoter and checked its activity in transient transf…