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showing 10 items of 591 documents

Global electrical heterogeneity as a predictor of cardiovascular mortality in men and women

2018

Aims The aim of this study was to investigate the contribution of depolarization and repolarization abnormalities, specially abnormalities in global electrical heterogeneity of heart in cardiovascular disease (CVD) and all-cause mortality. Methods and results Eight hundred and forty men and 911 women, average age of 63 years participated in this study with average follow-up was 14 years. Six electrocardiogram/vector electrocardiogram (ECG/VECG) markers QRS-duration, QTc-interval, QRST-angle, sum of absolute QRST integral (SAI QRST), T-wave roundness, and TV1-amplitude were estimated from VECG measurements. Hazard ratios (HRs) for CVD events (164 deaths) and all-cause mortality (383 deaths) …

Malekuolleisuusmedicine.medical_specialtyglobal electrical heterogeneityVectorcardiography030204 cardiovascular system & hematologyelectrocardiogramQT intervalRESTING HEART RATERisk Assessment03 medical and health sciencesElectrocardiography0302 clinical medicineSex FactorsRisk Factorscardiovascular diseasecardiovascular mortalityQRST-anglePhysiology (medical)Internal medicinemedicineMale populationRepolarizationHumanscardiovascular diseases030212 general & internal medicineEKGFinlandCardiovascular mortalitybusiness.industryHazard ratiota3142riskitekijätMiddle Agedta3121Confidence intervalElectrophysiological PhenomenaCardiovascular DiseasesRisk stratificationCardiologysydän- ja verisuonitauditFemaleseurantatutkimusCardiology and Cardiovascular MedicinebusinessEuropace
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Resting Electrocardiogram and Blood Pressure in Young Endurance and Nonendurance Athletes and Nonathletes.

2020

Context Much information is available on electrocardiogram (ECG) and blood pressure (BP) changes in senior athletes. However, corresponding data on adolescent athletes are scarce. Objective To study the differences in resting ECG and BP values among adolescent endurance athletes, nonendurance athletes, and nonathletes. Design Cross-sectional study. Setting A total of 154 youth sports clubs in Finland and 100 secondary schools for comparison data. Patients or Other Participants We recruited young athletes (n = 410) aged 14 to 16 years in 10 popular sport disciplines, including winter and summer as well as team and individual sports, and categorized them as endurance or nonendurance sports. …

Malemedicine.medical_specialtyAdolescentSinus bradycardiaRestPhysical Therapy Sports Therapy and RehabilitationContext (language use)Blood Pressure030204 cardiovascular system & hematologyCardiovascular System03 medical and health sciencesQRS complexElectrocardiography0302 clinical medicineHeart RateInternal medicineHeart ratemedicineHumansOrthopedics and Sports Medicinecardiovascular diseasesPR intervalbiologyAthletesbusiness.industry030229 sport sciencesGeneral Medicinebiology.organism_classificationAdaptation PhysiologicalPulse pressureBlood pressureCross-Sectional StudiesAthletesCardiologyFemalemedicine.symptombusinessElectrophysiologic Techniques CardiacSportsJournal of athletic training
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Clinical Benefit of Cardiac Resynchronization Therapy With a Defibrillator in Patients With an Ejection Fraction > 35% Estimated by Cardiac Magnet…

2014

A B S T R A C T Introduction and objectives: Cardiac resynchronization therapy with a defibrillator prolongs survival and improves quality of life in advanced heart failure. Traditionally, patients with ejection fraction > 35 estimated by echocardiography have been excluded. We assessed the prognostic impact of this therapy in a group of patients with severely depressed systolic function as assessed by echocardiography but with an ejection fraction > 35% as assessed by cardiac magnetic resonance. Methods: We analyzed consecutive patients admitted for decompensated heart failure between 2004 and 2011. The patients were in functional class II-IV, with a QRS to 120 ms, ejection fraction 35% es…

Malemedicine.medical_specialtyHeart Ventriclesmedicine.medical_treatmentCardiac resynchronization therapyMagnetic Resonance Imaging CineCardiac Resynchronization TherapyNecrosisQRS complexQuality of lifeInternal medicinemedicineHumansAgedHeart FailureEjection fractionmedicine.diagnostic_testbusiness.industryMyocardiumStroke VolumeMagnetic resonance imagingGeneral Medicinemedicine.diseaseImplantable cardioverter-defibrillatorDefibrillators ImplantableHeart failureVentricular FibrillationTachycardia VentricularCardiologyFemalebusinessCardiac magnetic resonanceRevista Española de Cardiología (English Edition)
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Complete analysis of the epidemiological scenario around a SARS-CoV-2 reinfection: previous infection events and subsequent transmission

2021

9 páginas, 3 figuras. The data that support the findings of this study (Fastq files) are publicly available. Fastq files above the GISAID thresholds were deposited at GISAID (hCoV-19/Spain/MD-IBV-99007733/2020, hCoV-19/Spain/MD-IBV-99007151/2020, hCoV-19/Spain/MD-IBV-99007734/2020, and hCoV-19/Spain/MDIBV-99007170/2020). All sequences were also deposited at the ENA (European Nucleotide Archive; https:// www.ebi.ac.uk/ena/browser/home) (ERR5698024, ERR5697187, ERR6459974, ERR5698025, and ERR5697254).

Malemedicine.medical_specialtyPediatricsEpidemiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PopulationContext (language use)MicrobiologySeverity of Illness IndexreinfectionEpidemiologyMedicineHumansTransmissionFamilySeroconversioneducationMolecular BiologyPhylogenyFirst episodeeducation.field_of_studyWhole Genome Sequencingbusiness.industryTransmission (medicine)SARS-CoV-2transmissionCOVID-19GenomicsMiddle AgedQR1-502SpainReinfectionFemaleContact TracingbusinessContact tracingResearch Article
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How Can We Identify the Best Implantation Site for an ECG Event Recorder?

2000

ZELLERHOFF, C., et al.: How Can We Identify the Best Implantation Site for an ECG Event Recorder? The aim of this study was to show how to find the preferable implantation site for an ECG event recorder (ECG-ER). We compared the quality of bipolar ECG recordings (4-cm electrode distance, vertical position) in 65 patients at the following sites: left and right subclavicular, left and right anterior axillary line (4th-5th interspace), left and right of the sternum (4th-5th interspace), heart apex, and subxyphoidal. The results were compared to the standard ECG lead II. In 30 patients, an additional comparison between vertical and horizontal ECG registrations was done using the same sites. ECG…

Malemedicine.medical_specialtySternumbusiness.industryP waveImplantation SiteAxillary linesGeneral MedicineMiddle AgedQT intervalElectrodes ImplantedProsthesis ImplantationElectrocardiographyQRS complexInternal medicineHorizontal position representationCardiologymedicineHumansFemalecardiovascular diseasesCardiology and Cardiovascular MedicinebusinessStandard ECGPacing and Clinical Electrophysiology
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Head-to-Head Comparison of the Incremental Predictive Value of The Three Established Risk Markers, Hs-troponin I, C-Reactive Protein, and NT-proBNP, …

2020

Risk stratification among patients with coronary artery disease (CAD) is of considerable interest to potentially guide secondary preventive therapies. Cardiac troponins as well as C-reactive protein (hsCRP) and natriuretic peptides have emerged as biomarkers for risk stratification. The question remains if one of these biomarkers is superior in predicting adverse outcomes. Thus, we perform a head-to-head comparison between high-sensitivity troponin I (hsTnI), hsCRP, and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with CAD. Plasma levels were measured in a cohort of 2193 patients with documented CAD. The main outcome measures were cardiovascular (CV) death and/or nonfata…

Malemedicine.medical_specialtymedicine.drug_classHead to headMyocardial Infarctionlcsh:QR1-502030204 cardiovascular system & hematologyBiochemistryArticlelcsh:MicrobiologyCoronary artery disease03 medical and health sciences0302 clinical medicineInternal medicineNatriuretic Peptide BrainTroponin ImedicineNatriuretic peptideHumans030212 general & internal medicineMyocardial infarctioncardiovascular diseasesMolecular BiologyAgedbiologybusiness.industryhigh-sensitivity troponin ITroponin IC-reactive proteinHazard ratioMiddle Agedmedicine.diseasePeptide FragmentsN-terminal pro-brain natriuretic peptideC-Reactive ProteinCohortbiology.proteinCardiologyFemalehigh-sensitivity C-reactive proteinprognosisbusinessBiomarkerscoronary artery diseaseFollow-Up StudiesBiomolecules
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Magnitude of QRS duration reduction after biventricular pacing identifies responders to cardiac resynchronization therapy

2016

Background Several studies have investigated the association between native QRS duration (QRSd) or QRS narrowing and response to biventricular pacing. However, their results have been conflicting. The aim of our study was to determine the association between the relative change in QRS narrowing index (QI) and clinical outcome and prognosis in patients who undergo cardiac resynchronization therapy (CRT) implantation. Methods and results We included 311 patients in whom a CRT device was implanted in accordance with current guidelines for CRT. On implantation, the native QRS, the QRSd and the QI during CRT were measured. After 6 months, 220 (71%) patients showed a 10% reduction in LVESV. The m…

Malemedicine.medical_specialtymedicine.medical_treatmentCardiac resynchronization therapyHeart failure030204 cardiovascular system & hematologyFollow-Up StudieCohort Studies03 medical and health sciencesQRS complexReverse remodeling0302 clinical medicineHeart RateCardiovascular DiseaseInternal medicinemedicineHumansPacingIn patientProspective Studiescardiovascular diseases030212 general & internal medicineReverse remodelingAgedCardiac resynchronization therapyVentricular RemodelingECGbusiness.industryHazard ratioArea under the curveMiddle Agedmedicine.diseaseSurvival RateProspective StudieCardiovascular DiseasesHeart failurecardiovascular systemCardiologyFemaleCohort StudieCardiology and Cardiovascular MedicinebusinessFollow-Up StudiesHumanInternational Journal of Cardiology
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Cardiac Injury in COVID-19–Echoing Prognostication∗

2020

Background Myocardial injury is frequent among patients hospitalized with coronavirus disease-2019 (COVID-19) and is associated with a poor prognosis. However, the mechanisms of myocardial injury remain unclear and prior studies have not reported cardiovascular imaging data. Objectives This study sought to characterize the echocardiographic abnormalities associated with myocardial injury and their prognostic impact in patients with COVID-19. Methods We conducted an international, multicenter cohort study including 7 hospitals in New York City and Milan of hospitalized patients with laboratory-confirmed COVID-19 who had undergone transthoracic echocardiographic (TTE) and electrocardiographic…

Malemyocaardial injuryCoronary AngiographyElectrocardiographyPandemicVentricular Dysfunctionechocardiographymyocardial injuryOriginal Investigationechocardiography; inflammation; myocaardial injury; SARS-CoV-2; troponin; COVID-19COVID-19 coronavirus disease-2019biologyViral EpidemiologytroponinHeartMiddle AgedRV right ventriclemyocardial infarctionItalyTTE transthoracic echocardiographyFemaleCardiology and Cardiovascular MedicineCoronavirus InfectionsEditorial Comment2019-20 coronavirus outbreakCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Pneumonia ViralAKI acute kidney injuryECG electrocardiographyBetacoronavirusmedicineHumansPandemicsARDS acute respiratory distress syndromeIQR interquartile rangeAgedRetrospective Studiesbusiness.industrySARS-CoV-2MyocardiumCOVID-19medicine.diseasebiology.organism_classificationVirologyCOVID-19 Drug TreatmentCI confidence intervalOR odds ratioPneumoniaLV left ventricleinflammationACS acute coronary syndromeNew York CitybusinessCoronavirus InfectionsBetacoronavirusBiomarkersJournal of the American College of Cardiology
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Micro- to Nanoscale Bio-Hybrid Hydrogels Engineered by Ionizing Radiation

2021

Bio-hybrid hydrogels consist of a water-swollen hydrophilic polymer network encapsulating or conjugating single biomolecules, or larger and more complex biological constructs like whole cells. By modulating at least one dimension of the hydrogel system at the micro- or nanoscale, the activity of the biological component can be extremely upgraded with clear advantages for the development of therapeutic or diagnostic micro- and nano-devices. Gamma or e-beam irradiation of polymers allow a good control of the chemistry at the micro-/nanoscale with minimal recourse to toxic reactants and solvents. Another potential advantage is to obtain simultaneous sterilization when the absorbed doses are wi…

Materials sciencePolymerslcsh:QR1-502Nanotechnology02 engineering and technologyReview010402 general chemistry01 natural sciencesBiochemistrylcsh:MicrobiologyIonizing radiationradiation chemistrymicro-/nano-gel patternsHydrophilic polymersnanogelsTissue engineeringRadiation Ionizingradiation chemistry; micro-/nano-gel patterns; nanogels; bio-hybrid hydrogels; drug delivery; tissue engineeringMolecular BiologyNanoscopic scalechemistry.chemical_classificationBiomoleculeHydrogelsPolymer021001 nanoscience & nanotechnology0104 chemical scienceschemistrytissue engineeringSelf-healing hydrogelsDrug deliverydrug deliveryNanoparticlesbio-hybrid hydrogelsSettore CHIM/07 - Fondamenti Chimici Delle Tecnologie0210 nano-technology
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A Standardised Approach to the Biomechanical Evaluation of Tracheal Grafts

2021

[EN] The ideal tracheal substitute must have biomechanical properties comparable to the native trachea, but currently there is no standardised approach to evaluating these properties. Here we propose a novel method for evaluating and comparing the properties of tracheal substitutes, thus systematising both measurement and data curation. This system was tested by comparing native rabbit tracheas to frozen and decellularised specimens and determining the histological characteristics of those specimens. We performed radial compression tests on the anteroposterior tracheal axis and longitudinal axial tensile tests with the specimens anastomosed to the jaw connected to a measuring system. All ca…

Materials scienceVolume UnitBioengineeringtracheaBiochemistryMicrobiologyArticlebiomechanicsUltimate tensile strengthAnimalsHumansTissue engineeringBiomechanicsLongitudinal axisairway bioengineering biomechanics tissue engineering trachea transplantationMolecular BiologyTransplantationbioengineeringTissue ScaffoldsBiomechanicsrespiratory systemQR1-502Biomechanical PhenomenaTracheaTransplantationAirwayRadial compressionairwaytissue engineeringRabbitsBiomedical engineeringtransplantationBiomolecules
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