Search results for "QTc"
showing 4 items of 4 documents
A Phase I Study of Intravenous LBH589, a Novel Cinnamic Hydroxamic Acid Analogue Histone Deacetylase Inhibitor, in Patients with Refractory Hematolog…
2006
Abstract Purpose: LBH589 is a novel histone deacetylase inhibitor that inhibits proliferation and induces apoptosis in tumor cell lines. In this phase I study, LBH589 was administered i.v. as a 30-minute infusion on days 1 to 7 of a 21-day cycle. Experimental Design: Fifteen patients (median age, 63 years; range, 42-87 years) with acute myeloid leukemia (13 patients), acute lymphocytic leukemia (1 patient), or myelodysplastic syndrome (1 patient) were treated with LBH589 at the following dose levels (mg/m2): 4.8 (3 patients), 7.2 (3 patients), 9.0 (1 patient), 11.5 (3 patient), and 14.0 (5 patients). The levels of histone acetylation were measured using quantitative flow cytometry and plasm…
Electrocardiographic Abnormalities and Mortality in Epilepsy Patients
2021
Background and Objectives: People with epilepsy (PWE) have a 2–3 times higher mortality rate than the general population. Sudden unexpected death in epilepsy (SUDEP) comprises a significant proportion of premature deaths, whereas sudden cardiac death (SCD) is among the leading causes of sudden death in the general population. Cardiac pathologies are significantly more prevalent in PWE. Whether electrocardiographic (ECG) parameters are associated with remote death in PWE has yet to be elucidated. The study objective was to assess whether interictal ECG parameters are associated with mortality in the long-term. Materials and Methods: The study involved 471 epilepsy patients who were hospitali…
QT intervāla izmaiņas pie alkohola intoksikācijas
2020
QT intervāls ir viens no elektrokardiogrammas intervāliem, ja tas pagarinās, tad tas var novest pie neregulāra sirds ritma, kā arī samaņas zuduma, un pat nāvei. Alkohols (etanols) ir viena no vielām, kas pēc literatūras avotiem pagarina QT intervālu. QT dispersija ir starpība starp garāko un īsāko QT intervālu. Tā ir netiešs repolarizācijas heterogenitātes marķieris. QT dispersija virs normas var norādīt uz malignas kambaru aritmijas predispozīciju. Pētījuma mērķis: Analizēt QT intervāla un tā derivātu (QTd, QTc) izmaiņas pacientiem pie alkohola intoksikācijas salīdzinot šos datus ar kontroles grupu. Materiāli un metodes: Retrospektīvs pētījums, kurā tika izmantotas 100 pacientu vēstures. 7…
Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury.
2021
Introduction: Disorders in electroencephalography (EEG) are commonly noted in patients with traumatic brain injury (TBI) and may be associated with electrocardiographic disturbances. Electrographic seizures (ESz) are the most common features in these patients. This study aimed to explore the relationship between ESz and possible changes in QTc interval and spatial QRS-T angle both during ESz and after ESz resolution. Methods: Adult patients with TBI were studied. Surface 12-lead ECGs were recorded using a Cardiax device during ESz events and 15 min after their effective suppression using barbiturate infusion. The ESz events were diagnosed using Masimo Root or bispectral index (BIS) devices.…