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RESEARCH PRODUCT

Suppression of Electrographic Seizures Is Associated with Amelioration of QTc Interval Prolongation in Patients with Traumatic Brain Injury.

Todd T. SchlegelChiara RobbaRafael BadenesSami ZaidDorota Siwicka-gierobaWojciech DabrowskiMagdalena BielaczAndrzej Jaroszyński

subject

medicine.medical_specialtyTraumatic brain injurymedicine.drug_classseizureQTc intervalElectroencephalographyQT intervalArticlebrain–heart interactionInternal medicinemedicineIn patientcardiovascular diseasesCerebral oximetrymedicine.diagnostic_testbusiness.industryspatial QTS-T angletraumatic brain injuryRGeneral Medicinemedicine.diseaseBarbiturateBispectral indexQtc interval prolongationCardiologyMedicinebusiness

description

Introduction: Disorders in electroencephalography (EEG) are commonly noted in patients with traumatic brain injury (TBI) and may be associated with electrocardiographic disturbances. Electrographic seizures (ESz) are the most common features in these patients. This study aimed to explore the relationship between ESz and possible changes in QTc interval and spatial QRS-T angle both during ESz and after ESz resolution. Methods: Adult patients with TBI were studied. Surface 12-lead ECGs were recorded using a Cardiax device during ESz events and 15 min after their effective suppression using barbiturate infusion. The ESz events were diagnosed using Masimo Root or bispectral index (BIS) devices. Results: Of the 348 patients considered for possible inclusion, ESz were noted in 72, with ECG being recorded in 21. Prolonged QTc was noted during ESz but significantly ameliorated after ESz suppression (540.19 ± 60.68 ms vs. 478.67 ± 38.52 ms, p &lt

yearjournalcountryeditionlanguage
2021-11-18Journal of clinical medicine
10.3390/jcm10225374https://pubmed.ncbi.nlm.nih.gov/34830656