Search results for "Quantitative Biology"
showing 10 items of 1025 documents
Conjugate and cut loci in averaged orbital transfer
2006
The objective of this Note is to describe the conjugate and cut loci associated with the averaged energy minimization problem in coplanar orbit transfer.
Experimental and numerical enhancement of Vibrational Resonance in a neural circuit
2012
International audience; A neural circuit exactly ruled by the FitzHugh-Nagumo equations is excited by a biharmonic signal of frequencies f and F with respective amplitudes A and B. The magnitude spectrum of the circuit response is estimated at the low frequency driving f and presents a resonant behaviour versus the amplitude B of the high frequency. For the first time, it is shown experimentally that this Vibrational Resonance effect is much more pronounced when the two frequencies are multiple. This novel enhancement is also confirmed by numerical predictions. Applications of this nonlinear effect to the detection of weak stimuli are finally discussed.
Event-Based Trajectory Prediction Using Spiking Neural Networks
2021
International audience; In recent years, event-based sensors have been combined with spiking neural networks (SNNs) to create a new generation of bio-inspired artificial vision systems. These systems can process spatio-temporal data in real time, and are highly energy efficient. In this study, we used a new hybrid event-based camera in conjunction with a multi-layer spiking neural network trained with a spike-timing-dependent plasticity learning rule. We showed that neurons learn from repeated and correlated spatio-temporal patterns in an unsupervised way and become selective to motion features, such as direction and speed. This motion selectivity can then be used to predict ball trajectory…
Near-field control of optical bistability in a nanocavity
2009
Micro- and nanocavities allow for strong light confinement in very small volume [1]. They give opportunities for new experiments such as cavity quantum electrodynamics, waveguiding, light slowing or trapping…[2] The increase of the electromagnetic (EM) field in the cavity enhances the interaction between light and matter, resulting in the possible observation of nonlinear effects [3]. Several studies have recently been published on the observation and characterisation of nonlinear silicon cavities [4]. As a step further, we propose and demonstrate the feasibility of an innovative way to mechanically control the bistable operating regime of a nanovavity. Using a near-field tip, we switch the…
Demonstration of a reef knot microfiber resonator.
2009
We propose a new way to realize a microfiber optical resonator by implementing the topology of a reef knot using two microfibers. We describe how this structure, which includes 4 ports and can serve as an add-drop filter, can be fabricated. Resonances in an all-silica reef knot are measured and good fits are obtained from a simple resonator model. We also show the feasibility of assembling a hybrid silica-chalcogenide reef knot structure.
Congenital anomalies from a physics perspective. The key role of "manufacturing" volatility
2020
Genetic and environmental factors are traditionally seen as the sole causes of congenital anomalies. In this paper we introduce a third possible cause, namely random "manufacturing" discrepancies with respect to ``design'' values. A clear way to demonstrate the existence of this component is to ``shut'' the two others and to see whether or not there is remaining variability. Perfect clones raised under well controlled laboratory conditions fulfill the conditions for such a test. Carried out for four different species, the test reveals a variability remainder of the order of 10%-20% in terms of coefficient of variation. As an example, the CV of the volume of E.coli bacteria immediately after…
A 4x4 Logarithmic Spike Timing Encoding Scheme for Olfactory Sensor Applications
2007
International audience; This paper presents a 4 times 4 logarithmic spike-timing encoding scheme used to translate the output of an integrated tin oxide gas sensor array into spike sequence, which is exploited to perform gas recognition. Hydrogen, ethanol and carbon monoxide were used to characterize the gas sensor array. The collected data were then used to test the proposed circuit for spike encoding and gas recognition. Simulation results illustrate that a particular analyte gas generates a unique spike pattern with certain spike ordering sequence, which is independent of the gas concentration. This unique spike sequence can thus be used to recognize different gases. In addition, the con…
Expanding genetic graphs' potential to analyse ecological connectivity: assessment of graphs construction methods
2019
International audience; Dispersal movements are often constrained in human-shaped landscapes, thereby threatening species survival. Landscape genetics approaches are commonly used to analyse ecological connectivity because genetic data well reflect dispersal capacities. When species occupy discrete habitat patches, graph-theoretic methods are a particularly relevant approach to study dispersal-driven gene flow. The links of a genetic graph can be weighted using different genetic distances between populations (nodes). Similarly, graph pruning (link set selection) can rely on different criteria. However, despite growing interest in genetic graphs, the influence of these parameters remains mos…
Brain lateralization probed by water diffusion at the atomic to micrometric scale
2019
International audience; Combined neutron scattering and diffusion nuclear magnetic resonance experiments have been used to reveal significant interregional asymmetries (lateralization) in bovine brain hemispheres in terms of myelin arrangement and water dynamics at micron to atomic scales. Thicker myelin sheaths were found in the left hemisphere using neutron diffraction. 4.7 T dMRI and quasi-elastic neutron experiments highlighted significant differences in the properties of water dynamics in the two hemispheres. The results were interpreted in terms of hemisphere-dependent cellular composition (number of neurons, cell distribution, etc.) as well as specificity of neurological functions (s…
Coumarin-Phosphine-Based Smart Probes for Tracking Biologically Relevant Metal Complexes: From Theoretical to Biological Investigations
2016
International audience; Ten metal-based complexes and associated ligands have been synthesized and characterized. One of the metal ligands is a coumarin-phosphine derivative, which displays tunable fluorescence properties. The fluorescence is quenched in the case of the free ligand and ruthenium and osmium complexes, whereas it is strong for the gold complexes and phosphonium derivatives. These trends were rationalized by theoretical calculations, which revealed non-radiative channels involving a dark state for the free ligands that is lower in energy than the emissive state and is responsible for the quenching of fluorescence. For the Ru-II and Os-II complexes, other non-radiative channels…