Search results for "Quantitative"
showing 10 items of 2409 documents
SWATH-MS reveals a key role for IPO7 in the molecular mechanism underlying antitumor effects of curcumin on Chronic Myelogenous Leukemia cells
2016
Imatinib represents the elective drug for the treatment of patients with Chronic Myelogenous Leukemia (CML). However, albeit it is effective in controlling CML and preventing progression to blast crisis (BC), it is not curative. Therefore, it is mandatory to find novel therapeutic combinations to completely eradicate CML. It was described that CML cells expressing higher level of BCR-ABL show an increased glucose metabolism (termed aerobic glycolysis or Warburg effect) correlated with a non-hypoxic induction of HIF-1α, factor implicated in leukemia stem cells (LSCs) maintenance[1,2]. In the present study, we demonstrated that curcumin, an Indian spice with multiple anticancer properties, is…
Automated Determination of Paroxetine and Its Main Metabolite by Column Switching and On-Line High-Performance Liquid Chromatography
1994
An automated column-switching method coupled to isocratic high-performance liquid chromatography has been developed for simultaneous determination of blood levels of paroxetine and its nonconjugated main metabolite BRL 36610. The lower limits of detection were 9-15 nmol/L (3-5 ng/ml) and linearity between drug concentration and detector response was found for 0-1,500 nmol/L (0-500 ng/ml). The method could be applied to the analysis of serum samples obtained from depressed patients who were treated with daily oral doses of 20 or 40 mg of paroxetine. After the 20-mg dose, the mean blood level of paroxetine was 69 nM (23 ng/ml), whereas the metabolite BRL 36610 was detectable in only one of 5 …
An immune system model in discrete time based on the analogy with the central nervous system
1988
Jerne's model for the immune system formulated in terms of a neural network recently proposed by Weisbuch and Atlan is generalized to interactions with continuous coupling coefficients. It is shown that even the extended model can be solved analytically without the aid of computer simulations and exhibits one additional attractor, which corresponds to a configuration with high concentrations of active killer cells eventually causing death of the organism.
Carbonyl metallo immuno assay: a new application for Fourier transform infrared spectroscopy
2000
Abstract We describe here the development of a new, non-isotopic immunological assay termed CMIA (carbonyl metallo immunoassay) that uses metal carbonyl complexes as tracers and Fourier transform infrared spectroscopy (FT-IR) as the detection method. This assay is based on the particular spectral features of these complexes, which show very strong absorption bands in the 1800–2200 cm −1 spectral range where proteins and organic molecules do not absorb. In Section 1 , the optimisation of the quantitative detection of these tracers is detailed. In Section 2 , the implementation of mono-CMIA is described, including the CMIA assays of three antiepileptic drugs (carbamazepine, phenobarbital, phe…
Production of specific antibodies and development of a non-isotopic immunoassay for carbamazepine by the carbonyl metallo-immunoassay (CMIA) method.
1995
Abstract As part of our ongoing work to extend the range of applications of the non-isotopic carbonyl metalloimmunoassay (CMIA), previously developed in our laboratory, we describe here the first CMIA study of carbamazepine. The CMIA method uses a metal carbonyl complex as a non-isotopic tracer, and in this case we chose to employ the dicobalt hexacarbonyl moiety (Co2(CO)6) attached to an alkyne. Two organometallic tracers, 3 and 7 , were synthesized, differentiated by the nature and length of the spacer arm of the Co2(CO)6 moiety. Two different coupling methods were subsequently used to synthesize the immunogens 1 and 2, the first one used a carbodiimide, while the second, employed dimethy…
Il Paradigma della Città Fluida
2013
Nella recente crisi globale i poderosi flussi di capitali finanziari, sociali e relazionali che hanno alimentato la riqualificazione urbana nel corso degli ultimi quindici anni non sono più disponibili ad essere intercettati in maniera indiscriminata così come è stato possibile fino a qualche anno fa. Nell'era della crisi strutturale le città più dinamiche non sono più quelle in grado di attrarre progetti urbani iconici ed investitori spinti dal mercato immobiliare o dalla redditività delle attività ricreative, ma quelle città che, a partire dalle loro profonde e diversificate risorse culturali, saranno capaci di attuare una vera e propria “metamorfosi” per usarle come base per la creazione…
MRI using hyperpolarized noble gases.
1998
The aim of this study was to review the physical basis of MRI using hyperpolarized noble gases as well as the present status of preclinical and clinical applications. Non-radioactive noble gases with a nuclear spin 1/2 (He-3, Xe-129) can be hyperpolarized by optical pumping. Polarization is transferred from circularly polarized laser light to the noble-gas atoms via alkali-metal vapors (spin exchange) or metastable atoms (metastability exchange). Hyperpolarization results in a non-equilibrium polarization five orders of magnitude higher than the Boltzmann equilibrium compensating for the several 1000 times lower density of noble gases as compared with liquid state hydrogen concentrations in…
"Table 24" of "Studies of quantum chromodynamics with the ALEPH detector"
1997
Unfolded values of the the mean multiplicity and dispersion of the multiplicity distribution integrated over the full rapidity region.
"Table 3" of "Measurement of the spin density matrix for the rho0, K*(892)0 and Phi produced in Z0 decays."
1997
Helicity density matrices elements. The statistical and systematic errors are combined quadratically.
"Table 18" of "Studies of quantum chromodynamics with the ALEPH detector"
1997
Unfolded charged particle multiplicity distribution giving the probability to have a hadronic Z0 decay with N charged particles.