Search results for "R1"

A Bimolecular Multicellular Complementation System for the Detection of Syncytium Formation: A New Methodology for the Identification of Nipah Virus …

2019

Fusion of viral and cellular membranes is a key step during the viral life cycle. Enveloped viruses trigger this process by means of specialized viral proteins expressed on their surface, the so-called viral fusion proteins. There are multiple assays to analyze the viral entry including those that focus on the cell-cell fusion induced by some viral proteins. These methods often rely on the identification of multinucleated cells (syncytium) as a result of cell membrane fusions. In this manuscript, we describe a novel methodology for the study of cell-cell fusion. Our approach, named Bimolecular Multicellular Complementation (BiMuC), provides an adjustable platform to qualitatively and quanti…

Macrophage Scavenger Receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease

2020

AbstractObesity-associated inflammation is a key player in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the exact mechanisms remain incompletely understood. Here we demonstrate that macrophage scavenger receptor 1 (MSR1, CD204) expression is associated with the occurrence of hepatic lipid-laden foamy macrophages and correlates with the degree of steatosis and steatohepatitis in a cohort of 170 NAFLD patients. Mice lacking Msr1 are protected against high fat-cholesterol diet (HFD)-induced metabolic disorder, showing fewer hepatic lipid-laden foamy macrophages, less hepatic inflammation, improved dyslipidemia and glucose tolerance, while showing a change in hepatic …

"Table 7" of "Global baryon number conservation encoded in net-proton fluctuations measured in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV"

2020

Measured R1 values.

"Table 10" of "Global baryon number conservation encoded in net-proton fluctuations measured in Pb-Pb collisions at $\sqrt{s_{\rm NN}}$ = 2.76 TeV"

2020

R1 values vs. delaY.

Embeddings of a family of Danielewski hypersurfaces and certain \C^+-actions on \C^3

2006

International audience; We consider the family of complex polynomials in \C[x,y,z] of the form x^2y-z^2-xq(x,z). Two such polynomials P_1 and P_2 are equivalent if there is an automorphism \varphi of \C[x,y,z] such that \varphi(P_1)=P_2. We give a complete classification of the equivalence classes of these polynomials in the algebraic and analytic category.

Varieties of algebras with pseudoinvolution and polynomial growth

2017

Let A be an associative algebra with pseudoinvolution (Formula presented.) over an algebraically closed field of characteristic zero and let (Formula presented.) be its sequence of (Formula presented.) -codimensions. We shall prove that such a sequence is polynomially bounded if and only if the variety generated by A does not contain five explicitly described algebras with pseudoinvolution. As a consequence, we shall classify the varieties of algebras with pseudoinvolution of almost polynomial growth, i.e. varieties of exponential growth such that any proper subvariety has polynomial growth and, along the way, we shall give also the classification of their subvarieties. Finally, we shall de…

2014

Objectives: Emerging evidence suggests that maternal obesity (MO) predisposes offspring to obesity and the recently described non-alcoholic fatty pancreas disease (NAFPD) but involved mechanisms remain unclear. Using a pathophysiologically relevant murine model, we here investigated a role for the biological clock--molecular core circadian genes (CCG) in the generation of NAFPD. Design: Female C57BL6 mice were fed an obesogenic diet (OD) or standard chow (SC) for 6 weeks, prior to pregnancy and throughout gestation and lactation: resulting offspring were subsequently weaned onto either OD (Ob_Ob and Con_Ob) or standard chow (Ob_Con and Con_Con) for 6 months. Biochemical, pro-inflammatory an…

Challenges and Opportunities on Lipid Metabolism Disorders Diagnosis and Therapy: Novel Insights and Future Perspective

2021

Dyslipidemia has been globally recognized, for almost seven decades, as one of the most important risk factors for the development and complications of atherosclerotic cardiovascular disease (ASCVD) [...]

The Covid-19 containment effects of public health measures:A spatial difference-in-differences approach

2021

Abstract The paper studies the containment effects of public health measures to curb the spread of Covid‐19 during the first wave of the pandemic in spring 2020 in Germany. To identify the effects of six compound sets of public health measures, we employ a spatial difference‐in‐differences approach. We find that contact restrictions, mandatory wearing of face masks and closure of schools substantially contributed to flattening the infection curve. The significance of the impact of restaurant closure does not prove to be robust. No incremental effect is evidenced for closure of establishments and the shutdown of nonessential retail stores.

Exploration of the Activation Mechanism of the Epigenetic Regulator MLL3: A QM/MM Study

2021

The mixed lineage leukemia 3 or MLL3 is the enzyme in charge of the writing of an epigenetic mark through the methylation of lysine 4 from the N-terminal domain of histone 3 and its deregulation has been related to several cancer lines. An interesting feature of this enzyme comes from its regulation mechanism, which involves its binding to an activating dimer before it can be catalytically functional. Once the trimer is formed, the reaction mechanism proceeds through the deprotonation of the lysine followed by the methyl-transfer reaction. Here we present a detailed exploration of the activation mechanism through a QM/MM approach focusing on both steps of the reaction, aiming to provide new…